MAO Junqin, HOU Zhonghai, CHEN Dagui, ZHANG Wen. Anti-hyperlipi-demic effects of polysaccharide MA from Mytilus coruscus on experimental atherosclerosis in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 27-30. doi: 10.3969/j.issn.1006-0111.2014.01.007
| Citation:
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MAO Junqin, HOU Zhonghai, CHEN Dagui, ZHANG Wen. Anti-hyperlipi-demic effects of polysaccharide MA from Mytilus coruscus on experimental atherosclerosis in rabbits[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(1): 27-30. doi: 10.3969/j.issn.1006-0111.2014.01.007
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Anti-hyperlipi-demic effects of polysaccharide MA from Mytilus coruscus on experimental atherosclerosis in rabbits
- 1.
No. 85th Hospital of PLA, Shanghai 200052, China
- 2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
- Received Date: 2013-07-30
- Rev Recd Date:
2013-09-14
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Abstract
Objective To explore the anti-hyperlipidemic effects and mechanism of polysaccharide MA from Mytilus coruscus in the experimental atherosclerosis rabbits and to observe the effects of MA on liver and aorta. Methods The atherosclerosis rabbit model was established by high-fat diet. The blood lipid such as triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) in serum and enzymes metabolizing blood lipid such as lipoprteinlipase (LPL), hepaticlipase (HL) and hydroxymethylglutaryl CoA reductase (HMG-CoAR) were measured after atherosclerosis rabbits fed MA for 4 weeks. Histopathology and ultramicroscopic structure of hepatic tissue was observed. Lipid storage in aortic atherosclerotic plaque was observed by the oil red staining method. Results MA significantly reduced the level of TG, TC, LDL in serum and increased HL, LPL (P<0.05). MA reduced lipid storage in liver and aortic atherosclerotic plaque. Conclusion MA might play regulating effects in serum lipid by enhancing the activities of LPL and HL, and inhibit formation of atherosclerosis and fatty liver.
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