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Volume 31 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(6): 451-453

MA Jian-li, LIU Gui-yang, LI Xiang, HUANG Xin-xin, YAO Fei, MA Xiao-hui. Determination of baicalin and cinnamic acid in Bianyan oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 451-453. doi: 10.3969/j.issn.1006-0111.2013.06.015
Citation: MA Jian-li, LIU Gui-yang, LI Xiang, HUANG Xin-xin, YAO Fei, MA Xiao-hui. Determination of baicalin and cinnamic acid in Bianyan oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 451-453. doi: 10.3969/j.issn.1006-0111.2013.06.015
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Determination of baicalin and cinnamic acid in Bianyan oral solution by HPLC

doi: 10.3969/j.issn.1006-0111.2013.06.015
  • 1.

    Department of Pharmacy, First Affiliated Hospital of PLA General Hospital, Beijing 100048, China

  • 2.

    Department of Pharmacy, Beijing Military Region Air Force Outpatient, Beijing 100061, China

  • Received Date: 2012-12-17
  • Rev Recd Date: 2013-04-08
  • Objective To establish an HPLC method for determination of baicalin and cinnamic acid in Bianyan oral solution simultaneously. Methods The Agilent Eclipse XDB-C18(4.6 mm×150 mm, 5 μm)was used, the mobile phase consisted of ACN-2% acetic acid (23:77), the flow rate was 1.0 ml/min, the detection wavelength was at 280 nm, the column temperature was at room temperature, and the inject volume was 10 μl. Results A good linear correlation was observed within the range of 0.085 1~3.404 8 g for baicalin (r=0.999 9) and 0.020 3~0.811 2 g for cinnamic acid(r=0.999 9). The average recovery (n=6) was 101.68% with RSD 2.85% for baicalin and 101.46% with RSD 2.07% for cinnamic acid. Conclusion The method was rapid, simple and accurate, which could be used for the overall quality control of Bianyan oral solution.
  • [1] 国家药典委员会.中华人民共和国药典2010年版一部[S]. 北京:中国化学工业出版社,2010:108.
    [2] 雷 芳.黄芩苷药理作用研究进展[J]. 中国药业, 2010, 19(15):87.
    [3] 张春乐,宋康康,陈祥仁,等.肉桂酸及其衍生物的抑菌活性研究[J].厦门大学学报:自然科学版,2006, 45(增):16.
    [4] 李 翔,刘皈阳,马建丽,等.HPLC法测定扁咽口服液中黄芩苷的含量[J].解放军药学学报,2012,28(3):254.
    [5] 李 翔, 刘皈阳, 马建丽, 等. 扁咽口服液生产过程中黄芩苷转移率的研究[J]. 药学实践杂志,2012,30(4):289.
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Determination of baicalin and cinnamic acid in Bianyan oral solution by HPLC

doi: 10.3969/j.issn.1006-0111.2013.06.015
  • 1. Department of Pharmacy, First Affiliated Hospital of PLA General Hospital, Beijing 100048, China
  • 2. Department of Pharmacy, Beijing Military Region Air Force Outpatient, Beijing 100061, China
  • Received Date: 2012-12-17
  • Rev Recd Date: 2013-04-08

Abstract: Objective To establish an HPLC method for determination of baicalin and cinnamic acid in Bianyan oral solution simultaneously. Methods The Agilent Eclipse XDB-C18(4.6 mm×150 mm, 5 μm)was used, the mobile phase consisted of ACN-2% acetic acid (23:77), the flow rate was 1.0 ml/min, the detection wavelength was at 280 nm, the column temperature was at room temperature, and the inject volume was 10 μl. Results A good linear correlation was observed within the range of 0.085 1~3.404 8 g for baicalin (r=0.999 9) and 0.020 3~0.811 2 g for cinnamic acid(r=0.999 9). The average recovery (n=6) was 101.68% with RSD 2.85% for baicalin and 101.46% with RSD 2.07% for cinnamic acid. Conclusion The method was rapid, simple and accurate, which could be used for the overall quality control of Bianyan oral solution.

MA Jian-li, LIU Gui-yang, LI Xiang, HUANG Xin-xin, YAO Fei, MA Xiao-hui. Determination of baicalin and cinnamic acid in Bianyan oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 451-453. doi: 10.3969/j.issn.1006-0111.2013.06.015
Citation: MA Jian-li, LIU Gui-yang, LI Xiang, HUANG Xin-xin, YAO Fei, MA Xiao-hui. Determination of baicalin and cinnamic acid in Bianyan oral solution by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(6): 451-453. doi: 10.3969/j.issn.1006-0111.2013.06.015
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