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Volume 31 Issue 4
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2013  >  31(4): 258-261

YUAN Li-hui, BIAN Jun. Preparation of nicardipine hydrochloride sustained-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 258-261. doi: 10.3969/j.issn.1006-0111.2013.04.005
Citation: YUAN Li-hui, BIAN Jun. Preparation of nicardipine hydrochloride sustained-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 258-261. doi: 10.3969/j.issn.1006-0111.2013.04.005
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Preparation of nicardipine hydrochloride sustained-release pellets

doi: 10.3969/j.issn.1006-0111.2013.04.005

  • Department of Pharmacy, 411th Hospital of PLA, Shanghai 200434, China

  • Received Date: 2012-09-04
  • Rev Recd Date: 2013-04-08
  • Objective To prepare nicardipine hydrochloride sustained-release pellets and investigate the influencing factors of the drug release in vitro. Methods The rapid-release pellets were prepared by fluidized bed coating method based on blank pill core and then nicardipine hydrochloride sustained-release pellets were prepared with surelease. The factors to influence the drug release behaviors and their properties were evaluated. Results The release percentage of the sustained-release pellets could be controlled by 24%, 69%, 87% at 2 h, 6 h, 12 h respectively, the drug release mechanism in vitro followed first-order equations. Conclusion The pellets showed an obviously sustained-release effect.The preparation process was simple and convenient.
  • [1] 陈新谦,金有豫,汤 光.新编药物学[M].第16版.北京:人民卫生出版社,2007:365.
    [2] 中国药典2010年版.二部[S]. 2010:附录87.
    [3] Costa P,Sousa LJM.Modeling and comparison of dissolution profiles[J].Eur J Pharm Sci,2001,13(2):123.
    [4] 张 强,武凤兰.药剂学[M].北京:北京大学医学出版社,2005:52.
    [5] 李 霞,刘晓军,马桂芝,等.盐酸曲马多缓释微丸的制备及处方工艺考察[J].解放军药学学报,2007,23(3):78.
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Preparation of nicardipine hydrochloride sustained-release pellets

doi: 10.3969/j.issn.1006-0111.2013.04.005
  • Department of Pharmacy, 411th Hospital of PLA, Shanghai 200434, China
  • Received Date: 2012-09-04
  • Rev Recd Date: 2013-04-08

Abstract: Objective To prepare nicardipine hydrochloride sustained-release pellets and investigate the influencing factors of the drug release in vitro. Methods The rapid-release pellets were prepared by fluidized bed coating method based on blank pill core and then nicardipine hydrochloride sustained-release pellets were prepared with surelease. The factors to influence the drug release behaviors and their properties were evaluated. Results The release percentage of the sustained-release pellets could be controlled by 24%, 69%, 87% at 2 h, 6 h, 12 h respectively, the drug release mechanism in vitro followed first-order equations. Conclusion The pellets showed an obviously sustained-release effect.The preparation process was simple and convenient.

YUAN Li-hui, BIAN Jun. Preparation of nicardipine hydrochloride sustained-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 258-261. doi: 10.3969/j.issn.1006-0111.2013.04.005
Citation: YUAN Li-hui, BIAN Jun. Preparation of nicardipine hydrochloride sustained-release pellets[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(4): 258-261. doi: 10.3969/j.issn.1006-0111.2013.04.005
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