Application of in situ gel in cancer therapy

FAN Li; HE Wen-ting; GAO Shen

doi:10.3969/j.issn.1006-0111.2013.04.003

Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review, editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name

E-mail

Phone

Title

Content

Verification Code

In situ gel has shown special advantages in cancer therapy due to high local drug concentration and convenient administration, which made it be promising in future clinical application. In this paper, the application of in situ gel in different tumor types of breast cancer, liver cancer, pancreatic cancer therapy were reviewed for the past 5 years, and the development of in situ gel were prospected.

Application of in situ gel in cancer therapy

1. Department of Pharmaceutical Science, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. Department of Pharmacy, Fujian Traditional Chinese Medicine University, Fuzhou 350108, China

3. Department of Pharmacy, Changhai Hospital, Second Military Medical University, Shanghai 200433, China

Received Date: 2013-05-06

Rev Recd Date: 2013-05-19

Key words:

in situ gel /
cancer therapy

Abstract: In situ gel has shown special advantages in cancer therapy due to high local drug concentration and convenient administration, which made it be promising in future clinical application. In this paper, the application of in situ gel in different tumor types of breast cancer, liver cancer, pancreatic cancer therapy were reviewed for the past 5 years, and the development of in situ gel were prospected.

HTML

Reference (21)

[1]	Maugham SM, Hunter AC, Murray JC.Nanomedicine:current status and future prospects[J].FASEBJ.2005,19:311.
[2]	Kempf RA, Mitchell MS.Effects of chemotherapeutic agents on the immune response[J].Cancer Invest,1984,2:459.
[3]	Qien F,Stowe N,Liu EH,et al. Quantification of in vivo doxombicin transport from PLGA millirods in thermoablated rat livers[J].Control Release.2003, 91(1-2):157.
[4]	Ahmed M, Liu Z, Lukyanov AN, et al. Combination radiofrequency ablation with intratumoral liposome doxorubicin:effect on drug accumulation and coagulation in multiple tissues and tumor types in animals[J].Radiology, 2005, 235(2):469.
[5]	仇海镇,李娟.原位凝胶的研究进展及其在药剂学中的应用[J].医学信息,2010,4(23):4.
[6]	Gariepy ER, Shive M, Bichara A, et al. A thermosensitive chitosan-based hydrogel for the local delivery of paclitaxel[J].Eur J Pharm Biopharm,2004, 57:53.
[7]	Lei N, Gong CY, Qian ZY et al. Therapeutic application of injectable thermosensitive hydrogel in preventing local breast cancer recurrence and improving incision wound healing in a mouse model[J].Nanoscale,2012,4:5686.
[8]	Guo DD, Hong SH, Jiang HL, et al. Synergistic effects of Akt1 shRNA and paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel on breast cancer[J].Biomaterials, 2012,33:2272.
[9]	谢峰,杨甲梅.原发性肝癌间质化疗的实验及临床研究进展[J].中华普通外科杂志.2010,11,(25):943.
[10]	Leung TW, Yu S, Johnson PJ, et al. PhaseⅡstudy of the efficacy and safety of cisplatin-epinephrine injectable gel administered to patients with unresectable hepatocellular carcinoma[J].Clinoncol,2003,21(4):652.
[11]	Mok TS,Kanekal S, Lin XR, Pharmacokinetic study of intralesional cisplatin for the treatment of hepatocellular carcinoma[J].Cancer, 2001,91(12);2369.
[12]	Harbord M, Dawes RF, Barr H, et al. Palliation of patients with dysphagia due to advanced esophageal cancer by endoscopic injection of cisplatin/epinephrine injectable gel[J]. Gastrointest Endosc.2002,56(5):644.
[13]	药晋鹏,戴立里,李娟,等.载阿霉素的液-固相变型原位凝胶注射治疗兔VX2肝癌HIFU消融后残癌[J]. 中国介入影像与治疗学,2012,9(11):34.
[14]	Parkin DM, Bray F, Ferlay J, et al. Global cancer statistics, 2002[J].CA Cancer J Clin, 2005, 55(2):74.
[15]	Strocchi P, Dozza B, Pecorella I, et al. Lesions caused by ricin applied to rabbit eyes[J].Invest Ophthalmol Vis Sci,2005,46:1113.
[16]	Chen ZK,Lin LW,Weng XH,et al. Interstitial chemotherapy with ricin-loaded thermosensitive hydrogel in pancreatic cancer xenograft[J].Hepatobiliary Pancreat Dis Int, 2009,8(4):418.
[17]	Gao Y, Ren FZ, Ding BY,et al. A thermo-sensitive PLGA-PEG-PLGA hydrogel for sustained release of docetaxel[J]. J Drug Targeting, 2010, 1:12.
[18]	Maran A, Dadsetan M, Buenz M, et al. Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells[J]. J Biomed Mater Res,2013,1:6.
[19]	Lee H, Mok H, Lee S, et al. Target-specific intracellular delivery of siRNA using degradable hyaluronic acid nanogels[J]. Control Rel, 2001, 119(2):245.
[20]	Seruga B, Sterling L,Wang L, et al. Reporting of serious adverse drug reactions of targeted anticancer agents in pivotal phase Ⅲ clinical trials[J]. J Clin Oncol, 2011,9(2):174.
[21]	朱卫,徐元龙,李学明,智能纳米水凝胶及其药剂学研究新进展[J]. 中国新药杂志,2011,20(6):518.

Message Board

Application of in situ gel in cancer therapy

doi: 10.3969/j.issn.1006-0111.2013.04.003

Abstract

References

Proportional views

通讯作者: 陈斌, bchen63@163.com

Article Metrics

Related

Proportional views