Observation on clonidine on refractory essential hypertension

XU Yun-gen; ZHANG Ning; HE Yi

doi:10.3969/j.issn.1006-0111.2013.03.014

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Objective To explore the effect of clonidine on refractory essential hypertension. Methods A total of 47 patients suffered refractory essential hypertension were included in the study, which were accepted treatment of clonidine(75 μg/8 h for 1 week, if did not reach the standard, changed to 150 μg/8 h). The difference of the clinic blood pressure, ambulatory blood pressure monitoring (ABPM)and adverse reaction were compared before and after treatment. Results After treatment for four weeks, the clinic blood pressure and ABPM were significantly lower than that before treatment(P<0.05); the efficiency was 89.4% and 80.8% respectively, according to the clinic blood pressure and ABPM. Conclusion The clonidine had a good effect on refractory essential hypertension.

Observation on clonidine on refractory essential hypertension

Internal Medicine-cardiovascular Department, The Municipal Hospital of Taizhou, Taizhou 318000, China

Received Date: 2012-04-30

Rev Recd Date: 2012-11-28

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Abstract: Objective To explore the effect of clonidine on refractory essential hypertension. Methods A total of 47 patients suffered refractory essential hypertension were included in the study, which were accepted treatment of clonidine(75 μg/8 h for 1 week, if did not reach the standard, changed to 150 μg/8 h). The difference of the clinic blood pressure, ambulatory blood pressure monitoring (ABPM)and adverse reaction were compared before and after treatment. Results After treatment for four weeks, the clinic blood pressure and ABPM were significantly lower than that before treatment(P<0.05); the efficiency was 89.4% and 80.8% respectively, according to the clinic blood pressure and ABPM. Conclusion The clonidine had a good effect on refractory essential hypertension.

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Reference (6)

[1]	Calhoun DA, Jones D, Textor S, et al. Resistant hypertension:diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research[J]. Hypertension, 2008, 51:1403.
[2]	White WB, Morganroth J. Usefulness of ambulatory monitoring of blood pressure in assessing antihypertensive therapy[J].Am J Cardial, 1989, 63:94.
[3]	Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertention (The Symplicity HTN-2 Trial):a randomized controlled trial[J]. Lancet, 2010, 376(9756):1903.
[4]	Scheffers IJ, Kroon AA, Schmidli J, et al. Novel baroreflex antivation theraphy in resistant hypertension:results of European multi-center feasibility study[J]. J Am coll cardiol, 2010, 56(15):1254.
[5]	中国药典.二部[S]. 附录,2005:181.
[6]	陈文生,史月生,王伟忠,等.尾端延髓腹外侧区咪唑啉受体在可乐定中枢降压中的作用[J]. 第二军医大学学报,2004,25(8):835.

[1]	Calhoun DA, Jones D, Textor S, et al. Resistant hypertension:diagnosis, evaluation, and treatment. A scientific statement from the American Heart Association Professional Education Committee of the Council for High Blood Pressure Research[J]. Hypertension, 2008, 51:1403.
[2]	White WB, Morganroth J. Usefulness of ambulatory monitoring of blood pressure in assessing antihypertensive therapy[J].Am J Cardial, 1989, 63:94.
[3]	Symplicity HTN-2 Investigators. Renal sympathetic denervation in patients with treatment-resistant hypertention (The Symplicity HTN-2 Trial):a randomized controlled trial[J]. Lancet, 2010, 376(9756):1903.
[4]	Scheffers IJ, Kroon AA, Schmidli J, et al. Novel baroreflex antivation theraphy in resistant hypertension:results of European multi-center feasibility study[J]. J Am coll cardiol, 2010, 56(15):1254.
[5]	中国药典.二部[S]. 附录,2005:181.
[6]	陈文生,史月生,王伟忠,等.尾端延髓腹外侧区咪唑啉受体在可乐定中枢降压中的作用[J]. 第二军医大学学报,2004,25(8):835.

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Observation on clonidine on refractory essential hypertension

doi: 10.3969/j.issn.1006-0111.2013.03.014

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