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Volume 30 Issue 6
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(6): 454-456

HU Meng-shen, HONG Zhi-ling, HUANG Jian-ying. Determination of residue organic solvents in Loperamide Hydrochloride by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 454-456. doi: 10.3969/j.issn.1006-0111.2012.06.017
Citation: HU Meng-shen, HONG Zhi-ling, HUANG Jian-ying. Determination of residue organic solvents in Loperamide Hydrochloride by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 454-456. doi: 10.3969/j.issn.1006-0111.2012.06.017
shu

Determination of residue organic solvents in Loperamide Hydrochloride by headspace capillary gas chromatography

doi: 10.3969/j.issn.1006-0111.2012.06.017

  • Xiamen Institute for Drug Control, Xiamen 361012, China

  • Received Date: 2012-03-18
  • Rev Recd Date: 2012-07-06
  • Objective To develop a method of headspace capillary gas chromatography for determining residual organic solvents in loperamide hydrochloride. Methods The carrier gas was nitrogen and FID as detector. The nine organic solvents including methanol, isopropanol, n-hexane, ethyl acetate, tetrahydrofuran, chloroform, methyl isobutyl ketone, toluene, benzene were separated on a DB-624 capillary column(30 m×0.32 mm×0.25 μm)by programmable increased temperature and headspace gas chromatography. Results The nine organic solvents were separated and each of them showed linear relationship in the concentration range measured. The recoveries and RSDs were in range from 95.2% to 102.3% and 0.8% to 2.9%, respectively. Conclusion The method was simple, accurate and reproducible.
  • [1] 陶 寅,蔡锡明.盐酸洛哌丁胺的合成[J].四川化工,1996,17(3):22.
    [2] 谷高强,周 坤,黄淑萍,等.气相色谱法测定盐酸洛哌丁胺中四种有机溶剂残留量[J].中国医药,2009, 4(7):528.
    [3] 中国药典2010年版.二部[S]. 2010:附录61.
    [4] 戴寿沣,陈贵斌,陈 悦.顶空毛细管气相色谱法测定注射用头孢哌酮舒巴坦钠中残留溶剂[J].海峡药学,2012,24(2):53.
    [5] 姚 静,吴建敏,高家敏,等.顶空GC测定缬沙坦原料有机溶剂残留量[J].中国药事,2009,23(7):681.
    [6] 龚爱琴.顶空毛细管气相色谱法测定氟苯尼考中残留溶剂[J].海峡药学,2011,23(7):79.
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Determination of residue organic solvents in Loperamide Hydrochloride by headspace capillary gas chromatography

doi: 10.3969/j.issn.1006-0111.2012.06.017
  • Xiamen Institute for Drug Control, Xiamen 361012, China
  • Received Date: 2012-03-18
  • Rev Recd Date: 2012-07-06

Abstract: Objective To develop a method of headspace capillary gas chromatography for determining residual organic solvents in loperamide hydrochloride. Methods The carrier gas was nitrogen and FID as detector. The nine organic solvents including methanol, isopropanol, n-hexane, ethyl acetate, tetrahydrofuran, chloroform, methyl isobutyl ketone, toluene, benzene were separated on a DB-624 capillary column(30 m×0.32 mm×0.25 μm)by programmable increased temperature and headspace gas chromatography. Results The nine organic solvents were separated and each of them showed linear relationship in the concentration range measured. The recoveries and RSDs were in range from 95.2% to 102.3% and 0.8% to 2.9%, respectively. Conclusion The method was simple, accurate and reproducible.

HU Meng-shen, HONG Zhi-ling, HUANG Jian-ying. Determination of residue organic solvents in Loperamide Hydrochloride by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 454-456. doi: 10.3969/j.issn.1006-0111.2012.06.017
Citation: HU Meng-shen, HONG Zhi-ling, HUANG Jian-ying. Determination of residue organic solvents in Loperamide Hydrochloride by headspace capillary gas chromatography[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 454-456. doi: 10.3969/j.issn.1006-0111.2012.06.017
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