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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(6): 447-448

WU Ning-ning. Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014
Citation: WU Ning-ning. Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014
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Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma

doi: 10.3969/j.issn.1006-0111.2012.06.014

  • Department of Hematology, Second Hospital of Ningbo, Ningbo 315000, China

  • Received Date: 2012-02-21
  • Rev Recd Date: 2012-05-28
  • Objective To observe the efficiency and safety of thalidomide combined with dexamethasone in elderly patients with multiple myeloma. Methods A total of 50 elderly patients with multiple myeloma in initial treatment were administered thalidomide combined with dexamethasone. Thalidomide was administered at an initial dose of 50 mg once-daily orally followed by gradually increased in 50 mg according to patients' tolerance to a maximum of 200 mg once-daily orally, dexamethasone was administered at 20 mg once-daily IV in 1~4 d, 9~12 d and 17~20 d with 28 d as a course of treatment. The efficiency after 4 courses of treatment eva-luate was evauated. Results Complete remission were in 15 cases, immense partial remission in 12 cases, partial remission in 13 cases, no change in 5 cases and progression of disease in 5 cases. The total effective rate was 80%. During treatment, there were 17 patients suffering from hypersomnia, 16 onstipation, 16 lassitude, 10 increased blood sugar, 8 peripheral neuropathy and 3 rashes. All the patients could tolerant after expectant treatment. Conclusion It could be an effective method of thalidomide combined with dexamethasone in elderly patients with multiple myeloma.
  • [1] 沙信山,李永辉,张桂芳,等.小剂量沙利度胺联合长春地辛、吡喃阿霉素和地塞米松方案治疗老年多发性骨髓瘤[J].中华实用诊断与治疗杂志,2009,23(3):303.
    [2] 中国多发性骨髓瘤工作组.中国多发性骨髓瘤诊治指南[J].中华内科杂志,2008,47(10):869.
    [3] Facon T, Mary JY, Pegourie B, et al. Dexamethasone-based regi-mens versus melphalan-prednisone for elderly multiple myeloma patients ineligible for high-dose therapy[J]. Blood,2006,107(4):1292.
    [4] Fujita J,Mestre JR,Zeldis JB,et al.Thalidomide and its analogues inhibit lipop1ysaccharide mediated linduction of cyclooxygenase 2[J].Clin Cancer Res,2001,7(11):3349.
    [5] 顾惠慈.三氧化二砷联合化疗治疗难治复发多发骨髓瘤的临床疗效分析[J].实用诊断与治疗杂志,2006,20(12):918.
    [6] 张之南.血液病诊断及疗效标准[M].第2版,北京:科学出版社,1998:73.
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Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma

doi: 10.3969/j.issn.1006-0111.2012.06.014
  • Department of Hematology, Second Hospital of Ningbo, Ningbo 315000, China
  • Received Date: 2012-02-21
  • Rev Recd Date: 2012-05-28

Abstract: Objective To observe the efficiency and safety of thalidomide combined with dexamethasone in elderly patients with multiple myeloma. Methods A total of 50 elderly patients with multiple myeloma in initial treatment were administered thalidomide combined with dexamethasone. Thalidomide was administered at an initial dose of 50 mg once-daily orally followed by gradually increased in 50 mg according to patients' tolerance to a maximum of 200 mg once-daily orally, dexamethasone was administered at 20 mg once-daily IV in 1~4 d, 9~12 d and 17~20 d with 28 d as a course of treatment. The efficiency after 4 courses of treatment eva-luate was evauated. Results Complete remission were in 15 cases, immense partial remission in 12 cases, partial remission in 13 cases, no change in 5 cases and progression of disease in 5 cases. The total effective rate was 80%. During treatment, there were 17 patients suffering from hypersomnia, 16 onstipation, 16 lassitude, 10 increased blood sugar, 8 peripheral neuropathy and 3 rashes. All the patients could tolerant after expectant treatment. Conclusion It could be an effective method of thalidomide combined with dexamethasone in elderly patients with multiple myeloma.

WU Ning-ning. Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014
Citation: WU Ning-ning. Therapeutic effect and adverse reaction of Thalidomide combined with dexamethasone in elderly patients with multiple myeloma[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(6): 447-448. doi: 10.3969/j.issn.1006-0111.2012.06.014
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