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Volume 30 Issue 5
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(5): 369-371,375

CHEN Ye, WANG Yang, LIU Zhong-chen, LI Wen-jun, DENG Jing-jing, XU Li-feng. Preparation and in vitro release of Garcinia glycosides sustained-release tablets[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 369-371,375. doi: 10.3969/j.issn.1006-0111.2012.05.014
Citation: CHEN Ye, WANG Yang, LIU Zhong-chen, LI Wen-jun, DENG Jing-jing, XU Li-feng. Preparation and in vitro release of Garcinia glycosides sustained-release tablets[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 369-371,375. doi: 10.3969/j.issn.1006-0111.2012.05.014
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Preparation and in vitro release of Garcinia glycosides sustained-release tablets

doi: 10.3969/j.issn.1006-0111.2012.05.014

  • School of Pharmacy, Liaoning University, Shenyang 110036, China

  • Received Date: 2012-02-06
  • Rev Recd Date: 2012-05-22
  • Objective To prepare Garcinia glycosides sustained-release tables and study their in vitro release characteristics. Methods Garcinia glycosides sustained-release tablets were prepared by hydroxypropylmethyl cellulose (HPMC) as gel matrix material and ethyl cellulose (EC) as skeleton material. Factors influencing the release rate of Garcinia glycosides from the sustained-release tablets, such as pH of release medium, skeleton material and amount of HPMC, porogen of type and amount, and tabletting pressure, were studied. Results Garcinia glycosides release rate was controlled obviously by the specifications and amount of skeleton material and porogen type. While the influence of pH, speed and tabletting pressure had certain influences to the release rate. Conclusion The selected formulation of Garcinia glycosides sustained-release tablets was reasonable with good controllability and reproducibility.
  • [1] 徐利锋.藤黄酸苷衍生物和类似物及其制备方法和用途[P].中国专利,101289482A,2008-10-22.
    [2] Zong L,Chen LL,Zhang Y. Studies on nitrendipine sustained-release tablets and in vitro release se characteristics[J]. J China Pharm Univ,2004,35 (6):503.
    [3] 中国药典2010版.二部[S]. 2010:附录,87.
    [4] 颜耀东.缓释控释制剂的设计与开发[M]. 北京:中国医药科技出版社, 2006:68
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Preparation and in vitro release of Garcinia glycosides sustained-release tablets

doi: 10.3969/j.issn.1006-0111.2012.05.014
  • School of Pharmacy, Liaoning University, Shenyang 110036, China
  • Received Date: 2012-02-06
  • Rev Recd Date: 2012-05-22

Abstract: Objective To prepare Garcinia glycosides sustained-release tables and study their in vitro release characteristics. Methods Garcinia glycosides sustained-release tablets were prepared by hydroxypropylmethyl cellulose (HPMC) as gel matrix material and ethyl cellulose (EC) as skeleton material. Factors influencing the release rate of Garcinia glycosides from the sustained-release tablets, such as pH of release medium, skeleton material and amount of HPMC, porogen of type and amount, and tabletting pressure, were studied. Results Garcinia glycosides release rate was controlled obviously by the specifications and amount of skeleton material and porogen type. While the influence of pH, speed and tabletting pressure had certain influences to the release rate. Conclusion The selected formulation of Garcinia glycosides sustained-release tablets was reasonable with good controllability and reproducibility.

CHEN Ye, WANG Yang, LIU Zhong-chen, LI Wen-jun, DENG Jing-jing, XU Li-feng. Preparation and in vitro release of Garcinia glycosides sustained-release tablets[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 369-371,375. doi: 10.3969/j.issn.1006-0111.2012.05.014
Citation: CHEN Ye, WANG Yang, LIU Zhong-chen, LI Wen-jun, DENG Jing-jing, XU Li-feng. Preparation and in vitro release of Garcinia glycosides sustained-release tablets[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(5): 369-371,375. doi: 10.3969/j.issn.1006-0111.2012.05.014
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