Preparation and application of solid lipid nano-particles

XIA Ai-xiao; SONG Qian-qian; SUN yuan

doi:10.3969/j.issn.1006-0111.2012.05.003

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Objective To review the latest research progress of the solid lipid nano-particle. Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized. Results Many kinds of preparation methods of solid lipid nano-particle had advantages and disadvantages, the high pressure homogenization technique and micro-emulsion method were recommended. Adjusting preparation parameters could be adjusted drug encapsulation efficiency and drug delivering curve. Conclusion Solid lipid nano-particle was a kind of excellent performance, which could be promising new drug delivery system.

Preparation and application of solid lipid nano-particles

1. Department of Pharmacy, Taizhou hospital of Zhejiang Province, Linhai 317000, China

2. College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China

Received Date: 2011-10-25

Rev Recd Date: 2011-12-23

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Abstract: Objective To review the latest research progress of the solid lipid nano-particle. Methods Domestic and foreign representative literature information of solid lipid nano-particles and its application were analyzed and summarized. Results Many kinds of preparation methods of solid lipid nano-particle had advantages and disadvantages, the high pressure homogenization technique and micro-emulsion method were recommended. Adjusting preparation parameters could be adjusted drug encapsulation efficiency and drug delivering curve. Conclusion Solid lipid nano-particle was a kind of excellent performance, which could be promising new drug delivery system.

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Reference (21)

[1]	Wissing SA, Kayser O, Muller RH. Solid lipid nanoparticles for parenteral drug delivery[J]. Adv Drug Del Rev, 2004, 56(1):1257.
[2]	李燕真. 吡拉西坦固体脂质纳米粒的制备和脑靶向性研究[D].开封:河南大学, 2010.
[3]	姜孙旻,葛一凡,毕欣耘,等. 亲水性蛋白和多肽固体脂质纳米粒的制备方法[J].中国现代应用杂志,2010,7(27):595.
[4]	张继明,胡富强,应晓英,等.胰岛素固体脂质纳米粒的制备及其理化性质研究[J].中国药学杂志,2004,8(39):605.
[5]	陈桐楷, 李园, 林华庆,等. 高压乳匀法制备氢溴酸高乌甲素固体脂质纳米粒的工艺研究[J]. 中国药学杂志, 2010, 45(6):440.
[6]	王春龙, 江荣高, 刘健华,等. 羟基喜树碱脂肪乳的光照稳定性及其在家兔体内的药动学和肝靶向性[J]. 中草药, 2008, 39(5):696.
[7]	王婧雯, 汤海峰. 齐墩果酸固体脂质纳米粒的制备与质量评价[J]. 第四军医大学学报, 2007, 28(5):472.
[8]	张先洲, 陈晓清, 潘细贵,等. 青藤碱固体脂质纳米粒的制备[J]. 中国医院药学杂志, 2008, 28(24):2081.
[9]	王杰, 张强, 索中军,等. PEG表面修饰硬脂酸脂质纳米粒的制备与体外细胞摄取[J]. 药学学报, 2000, 35(8):622.
[10]	〖ZK(〗Fredrik I,Christian T.Analysis of the flow field in a high-pressure〖LL〗homogenizer[J]. Exp Therm Fluid Sci,2007, 58(11):148.〖ZK)〗
[11]	Feng Wb, Jian Yb, Yu S, et al. Studies on PEG-modified SLNs loading vinorelbine bitartrate (I):Preparation and evaluation in vitro[J]. Int J Pharm, 2008, 359(1-2):104.
[12]	Yassin AE, Anwer MK, Mowafy HA, et al. Optimization of 5-flurouracil solid-lipid nanoparticles:a preliminary study to treat colon cancer[J]. Int J Med Sci,2010,7(6):398.
[13]	Li S, Zhao B, Wang F, et al. Yak interferon-alpha loaded solid lipid nanoparticles for controlled release[J]. Res Vet Sci,2010, 88(1):143.
[14]	刘少彬, 胡海洋, 赵秀丽,等. 长春西汀固体脂质纳米粒的制备及其性质考察[J]. 沈阳药科大学学报, 2010, 27(5):335.
[15]	Venka TV, Manjunath K. Preparation, characterization and in vitrorelease kinetics of clozapine solid lipid nanoparticles[J]. J Controlled Release, 2004, 95(3):627.
[16]	贾慧卿. 地高辛固体脂质纳米粒的制备及其药物动力学研究[D].保定:河北大学,2008.
[17]	Mao SR, Wang YZ, Ji HY, et al. Preparation of solid lipid nanoparticles by microemulsion technique[J].Yao Xue Xue Bao, 2003, 38(8):624.
[18]	陈建,姜赛平.睾酮固体脂质纳米粒的药物动力学特点[J].浙江医学,2008,7(30):698.
[19]	Ye JS, Wang Q, Zhou X, et al. Injectable actarit-loaded solid lipid nanoparticles as passive targeting therapeutic agents for rheumatoid arthritis[J]. Int J Pharm, 2008, 352(1-2):273.
[20]	陈正明, 龙晓英, 丁沐淦,等. 固体脂质纳米粒作为维A酸经皮给药载体的研究[J]. 中国新药杂志, 2010, 19 (5):427.
[21]	Liu J, Gong T, Fu H, et al. Solid lipid nanoparticles for pulmonary delivery of insulin[J]. Int J Pharm, 2008, 356(1-2):333.

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Preparation and application of solid lipid nano-particles

doi: 10.3969/j.issn.1006-0111.2012.05.003

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