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Volume 30 Issue 3
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(3): 218-219

DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
Citation: DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
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The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose

doi: 10.3969/j.issn.1006-0111.2012.03.017

  • Department of Psychiatry, the 7th people's hospital of Shaoxing, Shaoxing 312000, China

  • Received Date: 2011-10-24
  • Rev Recd Date: 2012-03-05
  • Objective To study the relationship between steady-state plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose. Methods 148 schizophrenia patients were treated with quetiapine with the same dose (600 mg/d). The clinical efficacy and adverse reactions were evaluated with BPRS and TESS respectively, while the plasma concentration of quetiapine was tested at 2nd, 4th and 8th weekend. Results The plasma concentration of quetiapine had significant difference with the reduced rate of BPRS (P<0.05), but had no difference with the scores of TESS. Conclusions The testing of plasma concentration could help to distinguish the effective and toxic concentration of quetiapine in treatment of schizophrenia, which could help doctors to choose rational dose of quetiapine for each patients.
  • [1] 李文标,薛亚振,翟屹民,等,高效液相色谱紫外检测法测定奎硫平血清浓度[J].药物分析杂志,2003,23:247.
    [2] Hirsch SR, Link CG, Goldstein JM, et.al.ICI204, 636: a new atypical antipsychotic drug[J].Br J Psychiatry Suppl, 1996,29:45.
    [3] 喻东山.药物副反应量表的因子重组[J].四川精神卫生,1998,11(3):193.
    [4] 林建荣,董煜坤,陈国中,等,奎硫平和奋乃静治疗精神分裂症老年患者的对照研究[J].中华精神科杂志,2002,35(2):99.
    [5] 唐茂芹,胡 蕾,王松波,等,奎硫平治疗精神分裂症的血药浓度与临床疗效关系的研究[J].中华精神科杂志,2004,37(2):85.
    [6] Meyer JM. Novel antipsychotics and severe hyperlipidemia[J].Clin Psychopharmacol, 2001,21:369.
    [7] Kaneda Y, Ohmori T. Effects of quetiapine on gonadal axis hormones in male patients with schizophrenia: a preliminary, open study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2003,27:875.
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The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose

doi: 10.3969/j.issn.1006-0111.2012.03.017
  • Department of Psychiatry, the 7th people's hospital of Shaoxing, Shaoxing 312000, China
  • Received Date: 2011-10-24
  • Rev Recd Date: 2012-03-05

Abstract: Objective To study the relationship between steady-state plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose. Methods 148 schizophrenia patients were treated with quetiapine with the same dose (600 mg/d). The clinical efficacy and adverse reactions were evaluated with BPRS and TESS respectively, while the plasma concentration of quetiapine was tested at 2nd, 4th and 8th weekend. Results The plasma concentration of quetiapine had significant difference with the reduced rate of BPRS (P<0.05), but had no difference with the scores of TESS. Conclusions The testing of plasma concentration could help to distinguish the effective and toxic concentration of quetiapine in treatment of schizophrenia, which could help doctors to choose rational dose of quetiapine for each patients.

DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
Citation: DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
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