Synthesis of several symmetric α-dione by coupling method

WANG Peng; LI Bin; DONG Jun-xing

doi:10.3969/j.issn.1006-0111.2012.03.016

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Objective To design and synthesize octane-4,5-dione, decane-5,6-dione and dodecane-6, 7-dione with ethyl butyrate, ethyl pentannate and ethyl hexanoate as the corresponding starting materials. Methods TTarget products were synthesized by coupling reaction in the presence of sodium firstly and oxidation reaction with copper acetate secondly. Results octane-4,5-dione,decane-5,6-dione and dodecane-6,7 were synthesized. Conclusions The synthetic method was feasible and simple.

Synthesis of several symmetric α-dione by coupling method

1. The School of Pharmaceutical Engineering, Shenyang Pharmaceutical University,Shenyang 110016,China

2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850,China

Received Date: 2011-11-15

Rev Recd Date: 2012-04-06

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Abstract: Objective To design and synthesize octane-4,5-dione, decane-5,6-dione and dodecane-6, 7-dione with ethyl butyrate, ethyl pentannate and ethyl hexanoate as the corresponding starting materials. Methods TTarget products were synthesized by coupling reaction in the presence of sodium firstly and oxidation reaction with copper acetate secondly. Results octane-4,5-dione,decane-5,6-dione and dodecane-6,7 were synthesized. Conclusions The synthetic method was feasible and simple.

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Synthesis of several symmetric α-dione by coupling method

doi: 10.3969/j.issn.1006-0111.2012.03.016

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