BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing. The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
| Citation:
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BAO Lei-lei, CHEN Hai-fei, BIAN Jun, YUAN Bing. The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
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The effect of Jianbu Guanjie Capusule on level of correlative ingredients in osteoarthropathy model of rabbit
- Received Date: 2012-03-09
- Rev Recd Date:
2012-04-11
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Abstract
Objective To discuss the protection and mechanism of Jianbu Guanjie Capusule( JBGJ capsule) to the knee osteoarthritis of rabbit. Methods Thirty healthy New Zealand rabbits were divided into five groups randomly with parallel control methods.The five groups were model group, positive group, low dose group, middle dose group and high dose group, respectively.The osteoarthropathy of knee joint model was built according to the Japanese KangYan standard.The rabbits were given the drug in the next day after the model establishment. After six weeks, animal serum and slippery membranes were collected to be detected. Results The activity of SOD in serum was improved in the middle, high dose group and positive group, which had significant different with the model group(P<0.05).The nitric oxide (NO) in serum was raised in low, middle and high dose group. The middle dose group had significant different with the model group. Conclusion JBGJ capsule could improve the activity of Superoxide dismutase (SOD) in serum and the level of NO, which could obviously improved the pathological alteration in osteoarthropathy model of rabbit.
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