Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 30 Issue 3
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(3): 189-193

WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
Citation: WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
shu

Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension

doi: 10.3969/j.issn.1006-0111.2012.03.009
  • 1.

    Department of Pharmacy, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025,China;Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China

  • 2.

    Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China

  • Received Date: 2012-02-14
  • Rev Recd Date: 2012-03-23
  • Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution.
  • [1] 梁文权.生物药剂学与药物动力学[M].第3版.北京:人民教育出版社,2007:50.
    [2] Zhuang CY,Li N,Wang M,et al. Preparation and characterization of vinpocetine loaded nanostructured lipid carriers(NLC) for improved oral bioavailiability[J]. Int J Pharm,2010(394):183.
    [3] Zhang ZW,Bu HH,Gao ZW,et al. The characteristics and mechanism of simvastatin loaded lipid nanoparticles to increase oral bioavailability in rats[J]. Int J Pharm,2010(394):149.
    [4] Natalie LT,William NC,Christopher JHP. Lipid-based delivery systems and intestinal lymphatic drug transport:A mechanistic update[J]. Adv Drug Deli Rev,2008(60):712.
    [5] 王 娟,张 晶,宋洪涛,等. 西罗莫司单层高分子渗透泵控释片的制备及其体外释放特性研究[J]. 中国药房,2010,21(37):3503.
    [6] David JH.Oral lipid-based formulations[J]. Adv Drug Deli Rev,2007(59):668.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3839) PDF downloads(630) Cited by()

Related
Proportional views

Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension

doi: 10.3969/j.issn.1006-0111.2012.03.009
  • 1. Department of Pharmacy, Fuzhou General Hospital, Fujian Medical University, Fuzhou 350025,China;Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China
  • 2. Department of Pharmacy, General Hospital of Nanjing Military Region, Fuzhou 350025,China
  • Received Date: 2012-02-14
  • Rev Recd Date: 2012-03-23

Abstract: Objective To optimize the preparation and study in vitro releasing of SRL-NLC dispersion. Methods Central composite design-response surface methodology was used to optimize dispersion formulation,then in vitro releasing in 0.4% SDS(sodium lauryl sulfate) solution was explored by normal phase dialysis bag method. Results The optimal dispersion had PS(particle size):82.54nm,PI(polydisperity index):0.207, Zeta potential: -18.0 mv,DL (drug-loading): 1.829%, and EE(entrapment efficiency): 91.3%; SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4%SDS solution. Conclusion The optimal formulation had good feasibility and reproducibility, in vitro releasing curve showed SRL-NLC dispersion had a characterization of 60.1% accumulated releasing in 0.4% SDS solution.

WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
Citation: WU Hao, SONG Hong-tao. Preparation and in vitro releasing of sirolimus-nanostructured lipid carriers dispension[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 189-193. doi: 10.3969/j.issn.1006-0111.2012.03.009
shu

    HTML

Reference (6)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return