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Volume 30 Issue 2
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Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(2): 128-130,145

JIANG Yun-xia, JIN Rou-nan, WANG Bin, MA Wei-qi, ZHAN Qi. Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 128-130,145. doi: 10.3969/j.issn.1006-0111.2012.02.014
Citation: JIANG Yun-xia, JIN Rou-nan, WANG Bin, MA Wei-qi, ZHAN Qi. Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 128-130,145. doi: 10.3969/j.issn.1006-0111.2012.02.014
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Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests

doi: 10.3969/j.issn.1006-0111.2012.02.014

  • Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China

  • Received Date: 2011-06-12
  • Rev Recd Date: 2011-12-01
  • Objective To analysis the distribution and drug resistance of pathogens isolated from blood cultures in hospitalized patients in order to guide the rational application of antibiotics agents. Methods 230 cases of blood culture results in hospitalized patients during 2009 October to 2010 October were retrospectively analyzed. Results 63 strains of pathogenic bacteria were checked out. The detection rate gram-negative bacteria, gram-positive bacteria was 80.9%, 17.51%, 1.59% respectively. Main pathogenic bacteria were Escherichia coli, Klebsiella spp, Enterobacter, Pseudomonas aeruginosa, with detection rate of 20.63%, 12.7%, 9.52%, 9.52% respectively. The detection rate of E.faecalis, Staphylococcus epidermidis, and E.faecium were 9.52%, 1.59%, 1.59%. Detection rate of Escherichia coli and Klebsiella spp induced ESBL was 6.34% and 1.59%. The susceptibility of gram-negative bacteria to carbapenem, amikacin, piperacillin/tazobatam were above 84%. Conclusion Glycopeptide antibiotics such as vancomycin were the first choice to cure serious blood infection caused by gram-positive bacterial. Amikacin, β-lactam/β-actamase inhibitors compound, carbapenem were the first choice to cure serious blood infection caused by gram-negative bacterial.
  • [1] Ribas RM,Freitas C,Gontijo Filho PP.Nosocomial bloodstream infections:organisms,risk factors and resistant phenotypes in the Brazilian University Hospital[J].Braz J Infect Dis,2007,11(3):351.
    [2] 2008年Mohnarin细菌耐药监测报告[M].天津:天津科学技术出版社,2010:5,120.
    [3] 王 炜,许淑珍.2004~2007年医院血培养病原菌的种类及耐药性变迁[J]. 陕西医学杂志,2011,40(2):188.
    [4] 崔颖鹏,唐 蕾,唐 冰,等.血培养分离病原菌的菌群分布及耐药性变迁[J].中华医院感染学杂志,2008,18(2):292.
    [5] 张永信.根据抗菌药的特性选择最佳抗菌方案[J].上海医药,2010,31(3):107.
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Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests

doi: 10.3969/j.issn.1006-0111.2012.02.014
  • Department of Pharmacy, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai 200438, China
  • Received Date: 2011-06-12
  • Rev Recd Date: 2011-12-01

Abstract: Objective To analysis the distribution and drug resistance of pathogens isolated from blood cultures in hospitalized patients in order to guide the rational application of antibiotics agents. Methods 230 cases of blood culture results in hospitalized patients during 2009 October to 2010 October were retrospectively analyzed. Results 63 strains of pathogenic bacteria were checked out. The detection rate gram-negative bacteria, gram-positive bacteria was 80.9%, 17.51%, 1.59% respectively. Main pathogenic bacteria were Escherichia coli, Klebsiella spp, Enterobacter, Pseudomonas aeruginosa, with detection rate of 20.63%, 12.7%, 9.52%, 9.52% respectively. The detection rate of E.faecalis, Staphylococcus epidermidis, and E.faecium were 9.52%, 1.59%, 1.59%. Detection rate of Escherichia coli and Klebsiella spp induced ESBL was 6.34% and 1.59%. The susceptibility of gram-negative bacteria to carbapenem, amikacin, piperacillin/tazobatam were above 84%. Conclusion Glycopeptide antibiotics such as vancomycin were the first choice to cure serious blood infection caused by gram-positive bacterial. Amikacin, β-lactam/β-actamase inhibitors compound, carbapenem were the first choice to cure serious blood infection caused by gram-negative bacterial.

JIANG Yun-xia, JIN Rou-nan, WANG Bin, MA Wei-qi, ZHAN Qi. Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 128-130,145. doi: 10.3969/j.issn.1006-0111.2012.02.014
Citation: JIANG Yun-xia, JIN Rou-nan, WANG Bin, MA Wei-qi, ZHAN Qi. Analysis on rationality of antibiotics choice after blood culture and drug sensitivity tests[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 128-130,145. doi: 10.3969/j.issn.1006-0111.2012.02.014
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