Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 30 Issue 2
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(2): 100-102

LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
Citation: LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
shu

Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida

doi: 10.3969/j.issn.1006-0111.2012.02.006

  • Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • Received Date: 2011-05-27
  • Rev Recd Date: 2012-01-01
  • Objective To study the chemical constituents of the South China Sea gorgonian Muriceopsis flavida. Methods The compounds were isolated and purified by repeated column chromatographies including normal-phase silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structures were elucidated by the physicochemical evidences and spectra data. The in vitro bio-activities of the compounds were assessed by an agar diffusion test. Results Two sesquiterpenes were isolated and indentified as menverins C (1) and D (2). The two compounds showed different levels of antimicrobial activity in bioassay in vitro. In particular, compounds 1 and 2 displayed considerable growth inhibition toward bacterium Bacillus migaterium and the alga Chlorella fusca, respectively. Conclusions This was the first report of menverins C (1) and D (2) from the genus Muriceopsis. The antimicrobial activity of both compounds suggested a possible ecological role of these metabolites in the chemical defensive strategy of the gorgonian.
  • [1] 黄宗国. 中国海洋生物种类与分布[M]. 北京: 海洋出版社, 2008: 300.
    [2] 邱蕴绮, 漆淑华, 张 偲. 柳珊瑚中甾醇类化合物及其生物活性研究进展[J]. 中草药, 2009, 40(6): 985.
    [3] 张 文, 郭跃伟. 海洋生物柳珊瑚的化学成分及生物活性研究进展[J]. 中国天然药物, 2003, 1(2): 69.
    [4] Blunt JW, Copp BR, Hu WP, et al. Marine natural products[J]. Nat Prod Rep, 2011, 28(2): 196.
    [5] Zhang W, Guo YW, Gu YC. Secondary metabolites from the South China Sea invertebrates: chemistry and biological activity[J]. CurrMed Chem, 2006, 13 (17): 2041.
    [6] Kokke WCMC, Bihlin L, Fenical W, et al. Novel dinoflagaellate 4α-methylated sterols from four Caribbean gorgonians[J]. Phytochemistry, 1982, 21 (4): 881.
    [7] Zhang W, Guo YW, Mollo E, et al. Junceellonoids A and B, two new briarane diterpenoids from the Chinese gorgonian Junceella fragilis ridley[J]. Helv Chim Acta, 2004, 87(9): 2341.
    [8] Zhang W, Huang H, Ding Y, et al. Three new polyoxygented steroids from the species of the South China Sea gorgonian Muricella flexuosa and Menella verrucosa brundin[J]. Helv Chim Acta, 2006, 89(4): 813.
    [9] Zhang W, Guo YW, Mollo E, et al. Acanthovagasteroids A-D, four new 19-hydroxylated steroids from the South China Sea gorgonian Acanthogorgia vagae aurivillius[J]. J Nat Prod, 2004, 67 (12): 2083.
    [10] Zhang W, Guo YW, Gavagnin M, et al. Suberoretisteroids A-E, five new uncommon polyoxygenated steroid 24-ketals from the Hainan gorgonian Suberogorgia reticulata[J]. Helv Chim Acta, 2005, 88 (1): 87.
    [11] 徐圆缘, 李 玲, 易杨华, 等. 块花柳珊瑚化学成分的研究[J]. 第二军医大学学报, 2010, 31 (4): 421.
    [12] 刘桃芳, 汤 华, 李 玲, 等. 中国南海紫柳珊瑚中过氧化甾醇类化学成分的研究[J]. 第二军医大学学报, 2011, 32(5): 469.
    [13] Zhang W, Guo YW, Ernesto M, et al. Menverins A-D, new highly oxygenated guaiane lactones from Hainan gorgonian Menella verrucosa[J]. Helv Chim Acta, 2004, 87: 2919.
    [14] Li L, Wang CY, Mollo H, et al. Futher highly oxygenated guaiane lactones from the South China Sea gorgonian Menella sp[J]. Helv Chim Acta, 2008, 91(1): 111.
    [15] 郭 奇, 魏玉西, 王长云, 等. 枝网刺柳珊瑚Echinogorgia sassapo reticulate (Esper)的化学成分研究[J]. 中国海洋药物杂志, 2010, 29 (1): 32.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(3149) PDF downloads(359) Cited by()

Related
Proportional views

Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida

doi: 10.3969/j.issn.1006-0111.2012.02.006
  • Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, Shanghai 200433, China
  • Received Date: 2011-05-27
  • Rev Recd Date: 2012-01-01

Abstract: Objective To study the chemical constituents of the South China Sea gorgonian Muriceopsis flavida. Methods The compounds were isolated and purified by repeated column chromatographies including normal-phase silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structures were elucidated by the physicochemical evidences and spectra data. The in vitro bio-activities of the compounds were assessed by an agar diffusion test. Results Two sesquiterpenes were isolated and indentified as menverins C (1) and D (2). The two compounds showed different levels of antimicrobial activity in bioassay in vitro. In particular, compounds 1 and 2 displayed considerable growth inhibition toward bacterium Bacillus migaterium and the alga Chlorella fusca, respectively. Conclusions This was the first report of menverins C (1) and D (2) from the genus Muriceopsis. The antimicrobial activity of both compounds suggested a possible ecological role of these metabolites in the chemical defensive strategy of the gorgonian.

LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
Citation: LIU Tao-fang, TANG Hua, GONG Wei, SUN Peng, LIU Bao-shu, LI Ling, ZHANG Wen. Sesquiterpenes from the South China Sea gorgonian Muriceopsis flavida[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 100-102. doi: 10.3969/j.issn.1006-0111.2012.02.006
shu

    HTML

Reference (15)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return