Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis

SUN Lei; DENG Hua-ping; XI Zhong-xin; LI Xia; SUN Lian-na

doi:10.3969/j.issn.1006-0111.2012.02.004

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Volume 30 Issue 2

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Article Navigation > Journal of Pharmaceutical Practice and Service > 2012 > 30(2): 92-95,127

SUN Lei, DENG Hua-ping, XI Zhong-xin, LI Xia, SUN Lian-na. Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 92-95,127. doi: 10.3969/j.issn.1006-0111.2012.02.004

Citation:

SUN Lei, DENG Hua-ping, XI Zhong-xin, LI Xia, SUN Lian-na. Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 92-95,127. doi: 10.3969/j.issn.1006-0111.2012.02.004

Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis

doi: 10.3969/j.issn.1006-0111.2012.02.004

1.
School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
2.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-09-02
Rev Recd Date: 2011-12-21

Abstract

Hepatic fibrosis was the common feature of pathology in almost all patients with chronic liver injury, which led to cirrhosis gradually and liver cancer ultimately. The anti-hepatic fibrosis active ingredients from TCM, including flavones, alkaloids, terpenes and phenols compounds were reviewed with the action mechanism in this paper, which could provide some references for the further study about the anti-hepatic fibrosis of TCM.
- hepatic fibrosis,
- active ingredients of TCM,
- action mechanism

References

[1]	Lamireau T,Desmouliere A,Bioulac-Sage P,et al.Mechanisms of hepatic fibronegesis[J]. Arch Pediatr, 2002,9(4):392.
[2]	Pinzani M,Rombouts K.Liver fibrosis from the bench to clinical targets[J].Dig Liver Dis, 2004,36(8):231.
[3]	程君,杨云霞.黄芩苷对四氯化碳致亚急性肝纤维化小鼠的保护作用[J].华西药学杂志,2010,25(1):32.
[4]	刘世杰,姜宏齐,马英杰.黄芩苷通过抑制大鼠转化生长因子β1的表达发挥抗肝纤维化作用[J].哈尔滨医科大学学报,2011,45(2):128.
[5]	王新华,金东岭,何红梅,等.黄芩苷对抗结核药物肝损伤保护作用的实验研究[J].时珍国医国药,2009,20(7):1640.
[6]	何蔚,曾繁.灯盏花素对异丙肾上腺素引起大鼠心肌肥厚和纤维化的保护作用[J].中国药理学通报,2005,21(12):1514.
[7]	杜钢军,王梅,林海红,等.灯盏花的肝纤维化保护作用[J].河南大学学报,2009,28(3):170.
[8]	Wilmsen PK,Spada DS,Salvador M.Antioxidant activity of the flavonoid hesperidin in chemical and biological systems[J].J Agric Food Chem,2005,53(12):4757.
[9]	Yeh CC,Kao SJ,Lin CC,et al.The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro[J].Life Sci,2007,80(20):1821.
[10]	吴芙蓉,李俊,任丹阳.橙皮苷抗大鼠肝纤维化作用的实验研究[J].安徽医科大学学报,2011,46(4):358.
[11]	杨慧莹,林克荣.水飞蓟素治疗脂肪肝的作用机制[J].中华现代内科学杂志,2006,3(8):876.
[12]	曹立波,李兵,李佐军,等.水飞蓟素对肝纤维化小鼠的保护作用及机制探讨[J].中国药理学通报,2009,25(6):794.
[13]	Tsai JH,Liu JY,Wu TT,et al.Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats[J].J Viral Hepat,2008,15(7):508.
[14]	王建生,张海,牛瑞云.苦参素注射液治疗肝纤维化临床探讨[J].实用中西医结合临床,2003,3(4):29.
[15]	张晓芸,崔晓栋,郭军堂,等.苦参碱对血小板衍生生长因子介导的大鼠肝星状细胞迁移、增殖和凋亡的影响[J].中国慢性病预防与控制,2008,16(4):334.
[16]	梁建新,屈杏芬,曾文铤,等.氧化苦参碱治疗慢性乙型肝炎肝纤维化的作用机制[J].中国老年学杂志,2010,30(11):1505.
[17]	Shi GF,Li Q.Effects of oxymatrine on experimental hepatic fibrosis and its mechanism in vivo[J].J Nat Med,2011,9(6):0473.
[18]	Cai XH,Wang S,Chen BA.Reseaech advances on the pharmacological effects of tetrandrin[J].World J Gastroenterol,2005,11(2):268.
[19]	Hsu YC,Chiu YT,Cheng CC,et al. Antifibrotic effect of tetrandrine on hepatic stellate cells and rats with liver fibrosis[J].J Gastroen Hepatol,2007,22(1):99.
[20]	王拥泽,杨宏志,杨沛华.川芎嗪抗肝纤维化作用机制研究[J].河北中医药学报,2006,21(3):8.
[21]	马进,郑仕中,陆茵,等.川芎嗪抑制肝纤维化作用机制的研究进展[J].中国临床药理学杂志,2010,126(5):395.
[22]	Sue YM,Cheng CF,Chang CC,et al.Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethlpyrazine against gentamicin-induced apoptosis in murine renal tubular cells[J].Nephrol Dial Transplant,2009,24(3):769.
[23]	杨冬娣,刘金元.青蒿琥酯对肝纤维化小鼠肝组织中I型、III型胶原表达的影响[J].河南中医,2009,29(7):654.
[24]	杨冬娣,刘金元.青蒿琥酯对肝纤维化小鼠肝脏星状细胞凋亡和增生的影响[J].河南中医,2009,29(5):447.
[25]	来丽娜,杨柳絮,郭春花,等.青蒿琥酯抗大鼠免疫性肝纤维化的作用及机制研究[J].中国药理学通报,2011,27(1):125.
[26]	沈晓丹,曹莉,顾艳,等.蓝萼甲素体外细胞毒活性研究[J].中华中医药学刊,2011,29(6):1334.
[27]	Gao LW,Zhang J,Yang WH,et al.Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway[J].Toxicol in Vitro,2011,25(1):51.
[28]	Liu Q,Wang X,Zhang Y,et al.Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellar matrix production[J].Acta Pharmacol Sin,2010,31(7):839.
[29]	徐标,童巧霞.葫芦素B对小鼠日本血吸虫肝纤维化组织VEGF及氧化应激的影响[J].中药药理与临床,2009,25(6):33.
[30]	余万贵,张恒文,贺尚荣,等.三七总皂苷对肝纤维化小鼠血清中转化生长因子β₁及白介素-1的影响[J].时珍国医国药,2006,17(1):54.
[31]	曾文勇,石小枫,刘杞,等.三七总皂苷对肝纤维化大鼠胶原及TGF-β₁mRNA表达的影响[J].胃肠病学和肝病学杂志,2010,19(9):795.
[32]	欧阳灿辉,朱宣,张焜和,等.熊果酸对肝纤维化大鼠肝组织TGF-β₁和α-SMA表达的影响[J].世界华人消化杂志,2009,17(22):2237.
[33]	Asl MN,Hosseinzadeh H.Review of pharmacological effects of Glycyrrhiza sp. and its bioactive comgpounds[J].Phytother Res,2008,22(6):709.
[34]	Moro T,Shimoyama Y,Kushida M,et al.Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis[J].Life Sci,2008,83(15-16):531.
[35]	Dang SS,Wang BF,Cheng YA,et al.Inhibitory effects of saikosaponin-d on CCl₄-induced hepatic fibrogenesis in rats[J].World J Gastroemterol,2007,13(4):557.
[36]	Fan J,Li X,Li P,et al.Saikaosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury[J].Biochem cell biol,2007,85(2):189.
[37]	Tsai MK,Lin YL,Huang YT.Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats[J].Toxicol Appl Pharmacol,2010,242(2):155.
[38]	Lv Z,Song Y,Xue D,et al.Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells[J].J Ethnophacol,2010,132(2):384.
[39]	Yu MF,Zhou Y,Zheng S,et al.The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione inpassaged rat hepatic stellate cells[J].Lab Invest,2006,86(7):697.
[40]	Yasuda Y,Shimizu M,Sakai H,et al.(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R[J].Chem Biol Interact,2009,182(2-3):59.
[41]	Chávez E,Reyes-Gordillo K,Segovia J,et al.Resveratrol prevents fibrosis,NF-κB activation and TGF-β increases induced by chronic CCl₄ treatment in rats[J].J Appl Toxicol,2008,28(1):35.
[42]	Choi JH,Choi CY,Lee KJ,et al.Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice[J].J Med Food,2009,12(2):320.
[43]	Choi JH,Hwang YP,Choi CY,et al.Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats[J].Food Chem Toxicol,2010,48(11):3137.
[44]	徐波,陆茵,吴佳明,等.姜黄素抗肝纤维化分子机制研究进展[J].中国中医药信息杂志,2008,15(3):9.
[45]	Shu JC,He YJ,Lv X,et al.Curcumin prevents liver fibrosis by including apoptosis and suppressing action of hepatic stellate cells[J].J Nat Med,2009,63(4):415.
[46]	Fu Y,Zheng S,Lin J,et al.Curcumin protects the liver from CCl₄-caused injury and fibrogenesis by attenuating oxidative stess and suppressing inflammation[J].Mol Pharmacol,2008,73(2):399.

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通讯作者: 陈斌, bchen63@163.com

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沈阳化工大学材料科学与工程学院沈阳 110142

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Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis

1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

2. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

Received Date: 2011-09-02

Rev Recd Date: 2011-12-21

Key words:

Abstract: Hepatic fibrosis was the common feature of pathology in almost all patients with chronic liver injury, which led to cirrhosis gradually and liver cancer ultimately. The anti-hepatic fibrosis active ingredients from TCM, including flavones, alkaloids, terpenes and phenols compounds were reviewed with the action mechanism in this paper, which could provide some references for the further study about the anti-hepatic fibrosis of TCM.

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Reference (46)

[1]	Lamireau T,Desmouliere A,Bioulac-Sage P,et al.Mechanisms of hepatic fibronegesis[J]. Arch Pediatr, 2002,9(4):392.
[2]	Pinzani M,Rombouts K.Liver fibrosis from the bench to clinical targets[J].Dig Liver Dis, 2004,36(8):231.
[3]	程君,杨云霞.黄芩苷对四氯化碳致亚急性肝纤维化小鼠的保护作用[J].华西药学杂志,2010,25(1):32.
[4]	刘世杰,姜宏齐,马英杰.黄芩苷通过抑制大鼠转化生长因子β1的表达发挥抗肝纤维化作用[J].哈尔滨医科大学学报,2011,45(2):128.
[5]	王新华,金东岭,何红梅,等.黄芩苷对抗结核药物肝损伤保护作用的实验研究[J].时珍国医国药,2009,20(7):1640.
[6]	何蔚,曾繁.灯盏花素对异丙肾上腺素引起大鼠心肌肥厚和纤维化的保护作用[J].中国药理学通报,2005,21(12):1514.
[7]	杜钢军,王梅,林海红,等.灯盏花的肝纤维化保护作用[J].河南大学学报,2009,28(3):170.
[8]	Wilmsen PK,Spada DS,Salvador M.Antioxidant activity of the flavonoid hesperidin in chemical and biological systems[J].J Agric Food Chem,2005,53(12):4757.
[9]	Yeh CC,Kao SJ,Lin CC,et al.The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro[J].Life Sci,2007,80(20):1821.
[10]	吴芙蓉,李俊,任丹阳.橙皮苷抗大鼠肝纤维化作用的实验研究[J].安徽医科大学学报,2011,46(4):358.
[11]	杨慧莹,林克荣.水飞蓟素治疗脂肪肝的作用机制[J].中华现代内科学杂志,2006,3(8):876.
[12]	曹立波,李兵,李佐军,等.水飞蓟素对肝纤维化小鼠的保护作用及机制探讨[J].中国药理学通报,2009,25(6):794.
[13]	Tsai JH,Liu JY,Wu TT,et al.Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats[J].J Viral Hepat,2008,15(7):508.
[14]	王建生,张海,牛瑞云.苦参素注射液治疗肝纤维化临床探讨[J].实用中西医结合临床,2003,3(4):29.
[15]	张晓芸,崔晓栋,郭军堂,等.苦参碱对血小板衍生生长因子介导的大鼠肝星状细胞迁移、增殖和凋亡的影响[J].中国慢性病预防与控制,2008,16(4):334.
[16]	梁建新,屈杏芬,曾文铤,等.氧化苦参碱治疗慢性乙型肝炎肝纤维化的作用机制[J].中国老年学杂志,2010,30(11):1505.
[17]	Shi GF,Li Q.Effects of oxymatrine on experimental hepatic fibrosis and its mechanism in vivo[J].J Nat Med,2011,9(6):0473.
[18]	Cai XH,Wang S,Chen BA.Reseaech advances on the pharmacological effects of tetrandrin[J].World J Gastroenterol,2005,11(2):268.
[19]	Hsu YC,Chiu YT,Cheng CC,et al. Antifibrotic effect of tetrandrine on hepatic stellate cells and rats with liver fibrosis[J].J Gastroen Hepatol,2007,22(1):99.
[20]	王拥泽,杨宏志,杨沛华.川芎嗪抗肝纤维化作用机制研究[J].河北中医药学报,2006,21(3):8.
[21]	马进,郑仕中,陆茵,等.川芎嗪抑制肝纤维化作用机制的研究进展[J].中国临床药理学杂志,2010,126(5):395.
[22]	Sue YM,Cheng CF,Chang CC,et al.Antioxidation and anti-inflammation by haem oxygenase-1 contribute to protection by tetramethlpyrazine against gentamicin-induced apoptosis in murine renal tubular cells[J].Nephrol Dial Transplant,2009,24(3):769.
[23]	杨冬娣,刘金元.青蒿琥酯对肝纤维化小鼠肝组织中I型、III型胶原表达的影响[J].河南中医,2009,29(7):654.
[24]	杨冬娣,刘金元.青蒿琥酯对肝纤维化小鼠肝脏星状细胞凋亡和增生的影响[J].河南中医,2009,29(5):447.
[25]	来丽娜,杨柳絮,郭春花,等.青蒿琥酯抗大鼠免疫性肝纤维化的作用及机制研究[J].中国药理学通报,2011,27(1):125.
[26]	沈晓丹,曹莉,顾艳,等.蓝萼甲素体外细胞毒活性研究[J].中华中医药学刊,2011,29(6):1334.
[27]	Gao LW,Zhang J,Yang WH,et al.Glaucocalyxin A induces apoptosis in human leukemia HL-60 cells through mitochondria-mediated death pathway[J].Toxicol in Vitro,2011,25(1):51.
[28]	Liu Q,Wang X,Zhang Y,et al.Leukamenin F suppresses liver fibrogenesis by inhibiting both hepatic stellate cell proliferation and extracellar matrix production[J].Acta Pharmacol Sin,2010,31(7):839.
[29]	徐标,童巧霞.葫芦素B对小鼠日本血吸虫肝纤维化组织VEGF及氧化应激的影响[J].中药药理与临床,2009,25(6):33.
[30]	余万贵,张恒文,贺尚荣,等.三七总皂苷对肝纤维化小鼠血清中转化生长因子β₁及白介素-1的影响[J].时珍国医国药,2006,17(1):54.
[31]	曾文勇,石小枫,刘杞,等.三七总皂苷对肝纤维化大鼠胶原及TGF-β₁mRNA表达的影响[J].胃肠病学和肝病学杂志,2010,19(9):795.
[32]	欧阳灿辉,朱宣,张焜和,等.熊果酸对肝纤维化大鼠肝组织TGF-β₁和α-SMA表达的影响[J].世界华人消化杂志,2009,17(22):2237.
[33]	Asl MN,Hosseinzadeh H.Review of pharmacological effects of Glycyrrhiza sp. and its bioactive comgpounds[J].Phytother Res,2008,22(6):709.
[34]	Moro T,Shimoyama Y,Kushida M,et al.Glycyrrhizin and its metabolite inhibit Smad3-mediated type I collagen gene transcription and suppress experimental murine liver fibrosis[J].Life Sci,2008,83(15-16):531.
[35]	Dang SS,Wang BF,Cheng YA,et al.Inhibitory effects of saikosaponin-d on CCl₄-induced hepatic fibrogenesis in rats[J].World J Gastroemterol,2007,13(4):557.
[36]	Fan J,Li X,Li P,et al.Saikaosaponin-d attenuates the development of liver fibrosis by preventing hepatocyte injury[J].Biochem cell biol,2007,85(2):189.
[37]	Tsai MK,Lin YL,Huang YT.Effects of salvianolic acids on oxidative stress and hepatic fibrosis in rats[J].Toxicol Appl Pharmacol,2010,242(2):155.
[38]	Lv Z,Song Y,Xue D,et al.Effect of salvianolic-acid B on inhibiting MAPK signaling induced by transforming growth factor-β1 in activated rat hepatic stellate cells[J].J Ethnophacol,2010,132(2):384.
[39]	Yu MF,Zhou Y,Zheng S,et al.The antifibrogenic effect of (-)-epigallocatechin gallate results from the induction of de novo synthesis of glutathione inpassaged rat hepatic stellate cells[J].Lab Invest,2006,86(7):697.
[40]	Yasuda Y,Shimizu M,Sakai H,et al.(-)-Epigallocatechin gallate prevents carbon tetrachloride-induced rat hepatic fibrosis by inhibiting the expression of the PDGFRbeta and IGF-1R[J].Chem Biol Interact,2009,182(2-3):59.
[41]	Chávez E,Reyes-Gordillo K,Segovia J,et al.Resveratrol prevents fibrosis,NF-κB activation and TGF-β increases induced by chronic CCl₄ treatment in rats[J].J Appl Toxicol,2008,28(1):35.
[42]	Choi JH,Choi CY,Lee KJ,et al.Hepatoprotective effects of an anthocyanin fraction from purple-fleshed sweet potato against acetaminophen-induced liver damage in mice[J].J Med Food,2009,12(2):320.
[43]	Choi JH,Hwang YP,Choi CY,et al.Anti-fibrotic effects of the anthocyanins isolated from the purple-fleshed sweet potato on hepatic fibrosis induced by dimethylnitrosamine administration in rats[J].Food Chem Toxicol,2010,48(11):3137.
[44]	徐波,陆茵,吴佳明,等.姜黄素抗肝纤维化分子机制研究进展[J].中国中医药信息杂志,2008,15(3):9.
[45]	Shu JC,He YJ,Lv X,et al.Curcumin prevents liver fibrosis by including apoptosis and suppressing action of hepatic stellate cells[J].J Nat Med,2009,63(4):415.
[46]	Fu Y,Zheng S,Lin J,et al.Curcumin protects the liver from CCl₄-caused injury and fibrogenesis by attenuating oxidative stess and suppressing inflammation[J].Mol Pharmacol,2008,73(2):399.

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Advances in active ingredients and action mechanism of TCM in treatment of hepatic fibrosis

doi: 10.3969/j.issn.1006-0111.2012.02.004

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References

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通讯作者: 陈斌, bchen63@163.com

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