Message Board

Respected readers, authors and reviewers, you can add comments to this page on any questions about the contribution, review,        editing and publication of this journal. We will give you an answer as soon as possible. Thank you for your support!

Name
E-mail
Phone
Title
Content
Verification Code
x Close Forever Close
Volume 30 Issue 1
. 
Turn off MathJax
Article Contents
Article Navigation >  Journal of Pharmaceutical Practice and Service  > 2012  >  30(1): 49-51,63

LI Jue, JIA Fei, WU Yong-jiang. Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 49-51,63. doi: 10.3969/j.issn.1006-0111.2012.01.013
Citation: LI Jue, JIA Fei, WU Yong-jiang. Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 49-51,63. doi: 10.3969/j.issn.1006-0111.2012.01.013
shu

Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC

doi: 10.3969/j.issn.1006-0111.2012.01.013
  • 1.

    School of Pharmacy, Zhejiang University, Hangzhou 310012, China;Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China

  • 2.

    Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China

  • 3.

    School of Pharmacy, Zhejiang University, Hangzhou 310012, China

  • Received Date: 2011-04-29
  • Rev Recd Date: 2011-10-08
  • Objective To establish a HPLC method to determine the content and related substance of rosiglitazone hydrochloride tablets. Methods The analysis was achieved on a Diamonsil C18 column(250 mm×4.6 mm, 5 μm) using a mobile phase of 0.025 mol/L ammonium acetate-acetonitrile (50∶50). The detection wavelength was at 245 nm. Results There was good resolution among the peak of rosiglitazone, the main related substances and the degradable impurities after being destroyed. There was a good linear relationship between the peak area and the concentration of rosiglitazone in the range of 19.57~195.70 μg/ml (r=1.000 0, n=6). Regression equation could be expressed by A=68 525C+31 152, r=1.000 0 (n=6). The precision in a day (RSD﹤0.5%) and during the days (RSD﹤1.0%) were good. The average recovery was 99.8% (RSD=0.3%,n=9) and the limit of detection was 0.29 ng. The solution was stable for 10 hours. Conclusion The method was specific, accurate, sensitive and could be used to determine rosiglitazone.
  • [1] 王幼君,李淑芬.茄尼醇和尼古丁的提取与工艺研究[J].天津化工,2003,17(3):37.
    [2] 邹俊杰,曲 卫,冯晓云.盐酸罗格列酮片治疗2型糖尿病的疗效及安全性[J].药学服务与研究,2008,8(3):174.
    [3] 朱光宇.罗格列酮的临床应用进展[J].安徽医药,2005,9(9):644.
    [4] 郑国钢,方滢芝.RP-HPLC法测定盐酸罗格列酮含量及有关物质[J].药物分析杂志,2005,25(1):104.
    [5] 王国俊, 叶晓琳, 傅 萍.HPLC法测定复方罗格列酮盐酸二甲双胍片中罗格列酮的含量[J].中国药房,2009,20(1):57.
    [6] 庞晓华,陈春水.马来酸罗格列酮缓释片有关物质的测定[J].中国医药导报,2008,5(14):29.
    [7] 高立军,王维贤,梅兴国.高效液相色谱法测定罗格列酮钠片含量及有关物质[J].科学技术与工程,2006,6(12):1678.
  • 加载中
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索
Get Citation
PDF
XML

Article Metrics

Article views(2973) PDF downloads(316) Cited by()

Related
Proportional views

Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC

doi: 10.3969/j.issn.1006-0111.2012.01.013
  • 1. School of Pharmacy, Zhejiang University, Hangzhou 310012, China;Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
  • 2. Zhejiang Institute for Food and Drug Control, Hangzhou 310004, China
  • 3. School of Pharmacy, Zhejiang University, Hangzhou 310012, China
  • Received Date: 2011-04-29
  • Rev Recd Date: 2011-10-08

Abstract: Objective To establish a HPLC method to determine the content and related substance of rosiglitazone hydrochloride tablets. Methods The analysis was achieved on a Diamonsil C18 column(250 mm×4.6 mm, 5 μm) using a mobile phase of 0.025 mol/L ammonium acetate-acetonitrile (50∶50). The detection wavelength was at 245 nm. Results There was good resolution among the peak of rosiglitazone, the main related substances and the degradable impurities after being destroyed. There was a good linear relationship between the peak area and the concentration of rosiglitazone in the range of 19.57~195.70 μg/ml (r=1.000 0, n=6). Regression equation could be expressed by A=68 525C+31 152, r=1.000 0 (n=6). The precision in a day (RSD﹤0.5%) and during the days (RSD﹤1.0%) were good. The average recovery was 99.8% (RSD=0.3%,n=9) and the limit of detection was 0.29 ng. The solution was stable for 10 hours. Conclusion The method was specific, accurate, sensitive and could be used to determine rosiglitazone.

LI Jue, JIA Fei, WU Yong-jiang. Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 49-51,63. doi: 10.3969/j.issn.1006-0111.2012.01.013
Citation: LI Jue, JIA Fei, WU Yong-jiang. Determination of content of rosiglitazone hydrochloride tablets and related substance by HPLC[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(1): 49-51,63. doi: 10.3969/j.issn.1006-0111.2012.01.013
shu

    HTML

Reference (7)

Catalog

    版权所有：《药学实践与服务》编辑委员会

    Supervisor & Sponsors: Address: No 325 Guohe Road, ShanghaiPost Code: 200433

    Tel: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    Supported by: Beijing Renhe Information Technology Co., Ltd.  

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return