[1] HALBROOK C J, LYSSIOTIS C A, PASCA DI MAGLIANO M, et al. Pancreatic cancer: advances and challenges[J]. Cell, 2023, 186(8):1729-1754. doi:  10.1016/j.cell.2023.02.014
[2] ZHAO C F, GAO F, LI Q W, et al. The distributional characteristic and growing trend of pancreatic cancer in China[J]. Pancreas, 2019, 48(3):309-314. doi:  10.1097/MPA.0000000000001222
[3] ZHANG X F, MAO T B, ZHANG B, et al. Characterization of the genomic landscape in large-scale Chinese patients with pancreatic cancer[J]. EBioMedicine, 2022, 77:103897. doi:  10.1016/j.ebiom.2022.103897
[4] 王馨慧, 刘小英, 付文胜. 胰腺癌的中医药治疗研究进展[J]. 中国中西医结合消化杂志, 2022, 30(4):303-307.
[5] 万宇翔, 李丽玲, 张春光,等. 基于数据挖掘的胰腺癌组方规律研究[C]//第五届全国肿瘤阳光论坛暨中医精准控瘤高峰论坛会议论文集. 北京, 2021: 57-65.
[6] 左军, 张金龙, 胡晓阳. 白术化学成分及现代药理作用研究进展[J]. 辽宁中医药大学学报, 2021, 23(10):6-9.
[7] 王依明, 王秋红. 半夏的化学成分、药理作用及毒性研究进展[J]. 中国药房, 2020, 31(21):2676-2682.
[8] 马艳春, 范楚晨, 冯天甜,等. 茯苓的化学成分和药理作用研究进展[J]. 中医药学报, 2021, 49(12):108-111.
[9]

LI S, ZHANG B. Traditional Chinese medicine network pharmacology: theory, methodology and application[J]. Chin J Nat Med, 2013, 11(2):110-120.
[10]

Saikia S, Bordoloi M. Molecular docking: challenges, advances and its use in drug discovery perspective[J]. Current drug targets, 2019, 20(5):501-521. doi:  10.2174/1389450119666181022153016
[11]

HSIN K Y, GHOSH S, KITANO H. Combining machine learning systems and multiple docking simulation packages to improve docking prediction reliability for network pharmacology[J]. PLoS One, 2013, 8(12):e83922. doi:  10.1371/journal.pone.0083922
[12]

WOOD L D, CANTO M I, JAFFEE E M, et al. Pancreatic cancer: pathogenesis, screening, diagnosis, and treatment[J]. Gastroenterology, 2022, 163(2): 386-402.
[13] 刘鲁明. 中西医结合治疗胰腺癌的机遇与挑战[J]. 中国中西医结合杂志, 2019, 39(1):18-20.
[14] 徐光星, 何若苹. 国医大师何任学术思想浅析: 基于不同主症的胰腺癌辨治经验[J]. 浙江中医药大学学报, 2019, 43(10):1019-1023,1029.
[15] 董家潇, 金永生, 曹莺. 黄芩素抗肿瘤作用及其机制研究新进展[J]. 药学实践杂志, 2021, 39(1):9-12,43.
[16]

TAKAHASHI H, CHEN M C, PHAM H, et al. Baicalein, a component of Scutellaria baicalensis, induces apoptosis by Mcl-1 down-regulation in human pancreatic cancer cells[J]. Biochim Biophys Acta, 2011, 1813(8):1465-1474. doi:  10.1016/j.bbamcr.2011.05.003
[17]

PU W L, LUO Y Y, BAI R Y, et al. Baicalein inhibits acinar-to-ductal metaplasia of pancreatic acinal cell AR42J via improving the inflammatory microenvironment[J]. J Cell Physiol, 2018, 233(8):5747-5755. doi:  10.1002/jcp.26293
[18]

O’CALLAGHAN Y C, FOLEY D A, O’CONNELL N M, et al. Cytotoxic and apoptotic effects of the oxidized derivatives of stigmasterol in the U937 human monocytic cell line[J]. J Agric Food Chem, 2010, 58(19):10793-10798. doi:  10.1021/jf1023017
[19] 曹张琦. β-谷甾醇协同吉西他滨通过诱导凋亡和抑制上皮间质转化的抗胰腺癌作用研究[D]. 兰州: 兰州大学, 2019.
[20]

MA R, ZHANG Z H, XU J, et al. Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis[J]. Braz J Med Biol Res, 2021, 54(12):e11183. doi:  10.1590/1414-431x2021e11183
[21]

ZHANG L J, YIN M Z, FENG X, et al. Anti-inflammatory activity of four triterpenoids isolated from poriae cutis[J]. Foods, 2021, 10(12):3155. doi:  10.3390/foods10123155
[22] 陆家佳. 白术挥发性成分GC-MS分析及对五种肿瘤细胞抑制活性研究[J]. 海峡药学, 2016, 28(6):28-31.
[23]

ABULA Y, SU Y T, TUNIYAZI D, et al. Desmoglein 3 contributes to tumorigenicity of pancreatic ductal adenocarcinoma through activating Src–FAK signaling[J]. Animal Cells Syst, 2021, 25(3):195-202. doi:  10.1080/19768354.2021.1943707
[24]

ABRAMS S L, DUDA P, AKULA S M, et al. Effects of the mutant TP53 reactivator APR-246 on therapeutic sensitivity of pancreatic cancer cells in the presence and absence of WT-TP53[J]. Cells, 2022, 11(5):794. doi:  10.3390/cells11050794
[25]

SAHU N, CHAN E, CHU F, et al. Cotargeting of MEK and PDGFR/STAT3 pathways to treat pancreatic ductal adenocarcinoma[J]. Mol Cancer Ther, 2017, 16(9):1729-1738. doi:  10.1158/1535-7163.MCT-17-0009
[26]

TOMER B, KEREN M L, SHANI J, et al. R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers[J]. BMC Cancer, 2020, 20(1):531. doi:  10.1186/s12885-020-07005-x
[27]

MARIA K, LI R X, MILLS GORDON B, et al. Mechanical stress signaling in pancreatic cancer cells triggers p38 MAPK- and JNK-dependent cytoskeleton remodeling and promotes cell migration via Rac1/Cdc42/Myosin II[J]. Mol Cancer Res, 2022, 20(3):485-497. doi:  10.1158/1541-7786.MCR-21-0266
[28]

LESINA M, WÖRMANN S M, MORTON J, et al. RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine kras-driven pancreatic carcinogenesis[J]. J Clin Investig, 2016, 126(8):2919-2932. doi:  10.1172/JCI86477
[29]

LIU S S, ZHANG J F, YIN L Y, et al. The lncRNA RUNX1-IT1 regulates C-FOS transcription by interacting with RUNX1 in the process of pancreatic cancer proliferation, migration and invasion[J]. Cell Death Dis, 2020, 11(6):412. doi:  10.1038/s41419-020-2617-7
[30]

MASSIHNIA D, AVAN A, FUNEL N, et al. Phospho-Akt overexpression is prognostic and can be used to tailor the synergistic interaction of Akt inhibitors with gemcitabine in pancreatic cancer[J]. J Hematol Oncol, 2017, 10(1):1-17. doi:  10.1186/s13045-016-0379-6
[31]

TIWARI A, TASHIRO K, DIXIT A, et al. Loss of HIF1A from pancreatic cancer cells increases expression of PPP1R1B and degradation of p53 to promote invasion and metastasis[J]. Gastroenterology, 2020, 159(5): 1882-1897.
[32]

ZHANG J H, LAI F J, CHEN H, et al. Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1[J]. Oncol Lett, 2013, 5(1):43-48. doi:  10.3892/ol.2012.991
[33]

LI M Y, TANG D D, YANG T, et al. Apoptosis triggering, an important way for natural products from herbal medicines to treat pancreatic cancers[J]. Front Pharmacol, 2022, 12:796300. doi:  10.3389/fphar.2021.796300
[34]

KUMAGAI S, KOYAMA S, NISHIKAWA H. Antitumour immunity regulated by aberrant ERBB family signalling[J]. Nat Rev Cancer, 2021, 21(3):181-197. doi:  10.1038/s41568-020-00322-0
[35]

CAI D X, CHEN C J, SU Y X, et al. LRG1 in pancreatic cancer cells promotes inflammatory factor synthesis and the angiogenesis of HUVECs by activating VEGFR signaling[J]. J Gastrointest Oncol, 2022, 13(1):400-412. doi:  10.21037/jgo-21-910
[36]

VOUTSADAKIS I A. Mutations of p53 associated with pancreatic cancer and therapeutic implications[J]. Ann Hepatobiliary Pancreat Surg, 2021, 25(3):315-327. doi:  10.14701/ahbps.2021.25.3.315
[37]

QIU W L, KUO C Y, TIAN Y, et al. Dual roles of the activin signaling pathway in pancreatic cancer[J]. Biomedicines, 2021, 9(7):821. doi:  10.3390/biomedicines9070821