[1] MA J Q, WANG C Y, SUN Y B, et al. Comparative study of oral and intranasal puerarin for prevention of brain injury induced by acute high-altitude hypoxia[J]. Int J Pharm, 2020, 591:120002. doi:  10.1016/j.ijpharm.2020.120002
[2] 赵敏, 陈垚, 李文华. 高原低氧影响学习记忆功能的机制研究进展[J]. 西北国防医学杂志, 2019, 40(9):536-541. doi:  10.16021/j.cnki.1007-8622.2019.09.002
[3]

LI Y, WANG Y. Effects of long-term exposure to high altitude hypoxia on cognitive function and its mechanism: a narrative review[J]. Brain Sci, 2022, 12(6):808. doi:  10.3390/brainsci12060808
[4]

ZHU M X, XU M K, ZHANG K X, et al. Effect of acute exposure to hypobaric hypoxia on learning and memory in adult Sprague-Dawley rats[J]. Behav Brain Res, 2019, 367:82-90. doi:  10.1016/j.bbr.2019.03.047
[5]

WANG X B, HOU Y, LI Q Y, et al. Rhodiola crenulata attenuates apoptosis and mitochondrial energy metabolism disorder in rats with hypobaric hypoxia-induced brain injury by regulating the HIF-1α/microRNA 210/ISCU1/2(COX10) signaling pathway[J]. J Ethnopharmacol, 2019, 241:111801. doi:  10.1016/j.jep.2019.03.028
[6]

ZHOU F, WANG M D, JU J, et al. Schizandrin A protects against cerebral ischemia-reperfusion injury by suppressing inflammation and oxidative stress and regulating the AMPK/Nrf2 pathway regulation[J]. Am J Transl Res, 2019, 11(1):199.
[7]

CHEN C, LI B, CHEN H T, et al. Epigallocatechin-3-gallate ameliorated iron accumulation and apoptosis and promoted neuronal regeneration and memory/cognitive functions in the hippocampus induced by exposure to a chronic high-altitude hypoxia environment[J]. Neurochem Res, 2022, 47(8):2254-2262. doi:  10.1007/s11064-022-03611-2
[8]

ZHANG X Y, ZHANG X J, DANG Z C, et al. Cognitive protective mechanism of crocin pretreatment in rat submitted to acute high-altitude hypoxia exposure[J]. BioMed Res Int, 2020, 2020:1-15.
[9] 李燕. 利舒康胶囊对慢性缺血缺氧症侯群的疗效探讨[J]. 中西医结合心血管病电子杂志, 2018, 6(22): 102, 104.
[10]

XU H B, BARACSKAY P, O'NEILL J, et al. Assembly responses of hippocampal CA1 place cells predict learned behavior in goal-directed spatial tasks on the radial eight-arm maze[J]. Neuron, 2019, 101(1): 119-132. e4.
[11]

LI M X, ZHU Y T, LI J, et al. Effect and mechanism of verbascoside on hypoxic memory injury in plateau[J]. Phytother Res, 2019, 33(10):2692-2701. doi:  10.1002/ptr.6443
[12]

DU X, LIU T L, TAO W D, et al. Effect of aqueous extract of Astragalus membranaceus on behavioral cognition of rats living at high altitude[J]. Chung I Tsa Chih Ying Wen Pan, 2022, 42(1):58-64.
[13]

ZHANG Z A, SUN Y F, YUAN Z Y, et al. Insight into the effects of high-altitude hypoxic exposure on learning and memory[J]. Oxid Med Cell Longev, 2022, 2022:4163188.
[14]

JING L L, WU N Z, ZHANG J, et al. Protective effect of 5, 6, 7, 8-Tetrahydroxyflavone on high altitude cerebral edema in rats[J]. Eur J Pharmacol, 2022, 928:175121. doi:  10.1016/j.ejphar.2022.175121
[15]

KOESTER-HEGMANN C, BENGOETXEA H, KOSENKOV D, et al. High-altitude cognitive impairment is prevented by enriched environment including exercise via VEGF signaling[J]. Front Cell Neurosci, 2018, 12:532. doi:  10.3389/fnins.2018.00532
[16]

WU C T, DENG J S, HUANG W C, et al. Salvianolic acid C against acetaminophen-induced acute liver injury by attenuating inflammation, oxidative stress, and apoptosis through inhibition of the Keap1/Nrf2/HO-1 signaling[J]. Oxid Med Cell Longev, 2019, 2019:9056845.
[17] 姚娟, 吴平安, 李芸, 等. Keap1-Nrf2-ARE信号通路及其激活剂的研究进展[J]. 中国药理学通报, 2019, 35(10):1342-1346.
[18]

HUANG C Y, DENG J S, HUANG W C, et al. Attenuation of lipopolysaccharide-induced acute lung injury by hispolon in mice, through regulating the TLR4/PI3K/akt/mTOR and Keap1/Nrf2/HO-1 pathways, and suppressing oxidative stress-mediated ER stress-induced apoptosis and autophagy[J]. Nutrients, 2020, 12(6):1742. doi:  10.3390/nu12061742
[19]

LI J C, LU K M, SUN F L, et al. Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway[J]. J Transl Med, 2021, 19(1):96. doi:  10.1186/s12967-021-02745-1
[20] 马慧萍, 张俊, 贾正平, 等. 利舒康胶囊对模拟高原缺氧动物的保护作用研究[J]. 药学实践杂志, 2018, 36(3):255-259.
[21]

LIU X T, LIN X, ZHANG S Y, et al. Lycopene ameliorates oxidative stress in the aging chicken ovary via activation of Nrf2/HO-1 pathway[J]. Aging, 2018, 10(8):2016-2036. doi:  10.18632/aging.101526
[22]

MOKHTARI SANGDEHI S R, HAJIZADEH MOGHADDAM A, RANJBAR M. Anti-apoptotic effect of silymarin-loaded chitosan nanoparticles on hippocampal caspase-3 and Bcl-2 expression following cerebral ischemia/reperfusion injury[J]. Int J Neurosci, 2022, 132(11):1102-1109. doi:  10.1080/00207454.2020.1860971
[23]

ABOUTALEB N, SHAMSAEI N, KHAKSARI M, et al. Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation[J]. J Physiol Sci, 2015, 65(5):435-443. doi:  10.1007/s12576-015-0382-7
[24]

WANG J L, XU X X, JIA W Y, et al. Calcium-/ calmodulin-dependent protein kinase II (CaMKII) inhibition induces learning and memory impairment and apoptosis[J]. Oxid Med Cell Longev, 2021, 2021:4635054.
[25]

GUO Z Y, RUAN Z Z, ZHANG D D, et al. Rotenone impairs learning and memory in mice through microglia-mediated blood brain barrier disruption and neuronal apoptosis[J]. Chemosphere, 2022, 291(Pt 2): 132982.