[1] 鲁亚奇, 张晓, 王金金, 等. 补骨脂化学成分及药理作用研究进展[J]. 中国实验方剂学杂志, 2019, 25(3): 180-189. doi:  10.13422/j.cnki.syfjx.20182022
[2]

ALAM F, KHAN G N, BIN ASAD M H H. Psoralea corylifolia L: Ethnobotanical, biological, and chemical aspects: a review[J]. Phytother Res, 2018, 32(4): 597-615. doi:  10.1002/ptr.6006
[3]

BHALLA V K, NAYAK U R, DEV S. Some new flavonoids from[J]. Tetrahedron Lett, 1968, 9(20): 2401-2406. doi:  10.1016/S0040-4039(00)76141-7
[4]

ZAFAR S K, IQBAL S, MUMTAZ M, et al. Inhibitory mechanism exhibited by phenol-based natural products against DNA polymerase α from Psoralea corylifolia by molecular docking[J]. J Chem Soc Pak, 2018, 40(6): 1093-1102.
[5]

ZHAO H Y, CHEN Z L. Screening of aromatase inhibitors in traditional Chinese medicines by electrophoretically mediated microanalysis in a partially filled capillary[J]. J Sep Sci, 2013, 36(16): 2691-2697. doi:  10.1002/jssc.201300474
[6]

LEE S W, YUN B R, KIM M H, et al. Phenolic compounds isolated from Psoralea corylifolia inhibit IL-6-induced STAT3 activation[J]. Planta Med, 2012, 78(9): 903-906. doi:  10.1055/s-0031-1298482
[7]

KUNTZ S, WENZEL U, DANIEL H. Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines[J]. Eur J Nutr, 1999, 38(3): 133-142. doi:  10.1007/s003940050054
[8]

NEPAL M, ChOI H J, ChOI B Y, et al. Anti-angiogenic and anti-tumor activity of Bavachinin by targeting hypoxia-inducible factor-1α[J]. Eur J Pharmacol, 2012, 691(1-3): 28-37. doi:  10.1016/j.ejphar.2012.06.028
[9]

JEONG D, WATARI K, SHIROUZU T, et al. Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs[J]. Biol Pharm Bull, 2013, 36(1): 152-157. doi:  10.1248/bpb.b12-00871
[10]

HUNG S Y, LIN S C, WANG S Z, et al. Bavachinin induces G2/M cell cycle arrest and apoptosis via the ATM/ATR signaling pathway in human small cell lung cancer and shows an antitumor effect in the xenograft model[J]. J Agric Food Chem, 2021, 69(22): 6260-6270. doi:  10.1021/acs.jafc.1c01657
[11]

PAI J T, HSU M W, LEU Y L, et al. Induction of G2/M cell cycle arrest via p38/p21Waf1/Cip1-dependent signaling pathway activation by bavachinin in non-small-cell lung cancer cells[J]. Molecules, 2021, 26(17): 5161. doi:  10.3390/molecules26175161
[12]

FARAJZADEH M, Dehkordi. Deciphering the DNA-binding affinity, cytotoxicity and apoptosis induce as the anticancer mechanism of Bavachinin: an experimental and computational investigation[J]. J Mol Liq, 2021, 341: 117373. doi:  10.1016/j.molliq.2021.117373
[13]

GE L N, YAN L, LI C, et al. Bavachinin exhibits antitumor activity against non-small cell lung cancer by targeting PPARγ[J]. Mol Med Rep, 2019, 20(3): 2805-2811.
[14]

ZHAO C, GHOSH B, CHAKRABORTY T, et al. Bavachinin mitigates DMH induced colon cancer in rats by altering p53/Bcl2/BAX signaling associated with apoptosis[J]. Biotech Histochem, 2021, 96(3): 179-190. doi:  10.1080/10520295.2020.1778087
[15]

DARZI S, MIRZAEI S A, ELAHIAN F, et al. Improvement of cytotoxicity of mitoxantrone and daunorubicin by candidone, tephrosin, and bavachinin[J]. Mol Biol Rep, 2021, 48(11): 7105-7111. doi:  10.1007/s11033-021-06700-7
[16]

DARZI S, MIRZAEI S A, ELAHIAN F, et al. Enhancing the therapeutic efficacy of daunorubicin and mitoxantrone with bavachinin, candidone, and tephrosin[J]. Evid Based Complement Alternat Med, 2019, 2019: 3291737.
[17] 丁钦, 吴克俭, 郑璐, 等. 补骨脂二氢黄酮甲醚调控Gamma delta T细胞消减胃癌SGC-7901研究[J]. 世界中医药, 2020, 15(20): 3040-3045. doi:  10.3969/j.issn.1673-7202.2020.20.007
[18]

BILEŞIKLER K, BAKıŞ O. An overview on flavonoids as potential antiviral strategies against coronavirus infections[J]. Gazi Med J, 2020, 31(3A): 478-484. doi:  10.12996/gmj.2020.117
[19]

YOON J H, LEE J, LEE J Y, et al. Study on the 2-phenylchroman-4-one derivatives and their anti-MERS-CoV activities[J]. Bull Korean Chem Soc, 2019, 40(9): 906-909. doi:  10.1002/bkcs.11832
[20]

ZHAO H, CHEN Z. Screening of neuraminidase inhibitors from traditional Chinese medicines by integrating capillary electrophoresis with immobilized enzyme microreactor[J]. J Chromatogr A, 2014, 1340: 139-145. doi:  10.1016/j.chroma.2014.03.028
[21]

Yin S , Fan C Q , Wang Y , et al. Antibacterial prenylflavone derivatives from Psoralea corylifolia, and their structure-activity relationship study[J]. Bioorg Med Chem, 2004, 12(16): 4387-4392. doi:  10.1016/j.bmc.2004.06.014
[22] 王天晓, 尹震花, 张伟, 等. 补骨脂抗氧化、抑制α-葡萄糖苷酶和抗菌活性成分研究[J]. 中国中药杂志, 2013, 38(14): 2328-2333.
[23]

CUI Y M, TANIGUCHI S, KURODA T, et al. Constituents of Psoralea corylifolia fruits and their effects on methicillin-resistant Staphylococcus aureus[J]. Molecules, 2015, 20(7): 12500-12511. doi:  10.3390/molecules200712500
[24]

MA S, HUANG Y, ZHAO Y, et al. Prenylflavone derivatives from the seeds of Psoralea corylifolia exhibited PPAR-γ agonist activity[J]. Phytochem Lett, 2016, 16: 213-218. doi:  10.1016/j.phytol.2016.04.016
[25]

FENG L, LUO H, XU Z J, et al. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice[J]. Diabetologia, 2016, 59(6): 1276-1286. doi:  10.1007/s00125-016-3912-9
[26]

FENG L , LU S , ZHENG Z ,et al. Identification of an allosteric hotspot for additive activation of PPARγ in antidiabetic effects[J]. Sci Bull, 2021, 66(15): 1559-1570. doi:  10.1016/j.scib.2021.01.023
[27]

DU G, FENG L, YANG Z, et al. Separation and peroxisome proliferator-activated receptor-γ agonist activity evaluation of synthetic racemic bavachinin enantiomers[J]. Bioorg Med Chem Lett, 2015, 25(12): 2579-2583. doi:  10.1016/j.bmcl.2015.04.029
[28]

DU D G, ZHAO D Y, FENG D L, et al. Design synthesis and structure-activity relationships of bavachinin analogues as peroxisome proliferator-activated receptor γ agonists[J]. ChemMedChem, 2017, 12(2): 183-193. doi:  10.1002/cmdc.201600554
[29]

LYMAN M, LLOYD D G, JI X M, et al. Neuroinflammation: the role and consequences[J]. Neurosci Res, 2014, 79: 1-12. doi:  10.1016/j.neures.2013.10.004
[30]

KIM Y J, LIM H S, LEE J, et al. Quantitative analysis of Psoralea corylifolia linne and its neuroprotective and anti-neuroinflammatory effects in HT22 hippocampal cells and BV-2 microglia[J]. Molecules, 2016, 21(8): 1076. doi:  10.3390/molecules21081076
[31]

SORIA LOPEZ J A, GONZÁLEZ H M, LÉGER G C. Alzheimer’s disease[J]. Handb Clin Neurol, 2019, 167: 231-255.
[32]

CHEN Z J, YANG Y F, ZHANG Y T, et al. Dietary total prenylflavonoids from the fruits of Psoralea corylifolia L. prevents age-related cognitive deficits and down-regulates alzheimer’s markers in SAMP8 mice[J]. Molecules, 2018, 23(1): 196. doi:  10.3390/molecules23010196
[33] 杨柳, 李爽, 王业秋, 等. 补骨脂二氢黄酮甲醚对Aβ诱导PC12细胞损伤的保护作用及机制研究[J]. 中药新药与临床药理, 2021, 32(1): 68-72.
[34]

CHEN X, YANG Y, ZHANG Y. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro[J]. FEBS Lett, 2013, 587(18): 2930-2935. doi:  10.1016/j.febslet.2013.07.037
[35]

CHOI Y H, YON G H, HONG K S, et al. In vitro BACE-1 inhibitory phenolic components from the seeds of Psoralea corylifolia[J]. Planta Med, 2008, 74(11): 1405-1408. doi:  10.1055/s-2008-1081301
[36]

Thomas T. Monoamine oxidase-B inhibitors in the treatment of Alzheimers disease[J]. Neurobiol Aging, 2000, 21(2): 343-348. doi:  10.1016/S0197-4580(00)00100-7
[37]

ZARMOUH N O, MAZZIO E A, ELSHAMI F M, et al. Evaluation of the inhibitory effects of bavachinin and bavachin on human monoamine oxidases A and B[J]. Evid Based Complement Alternat Med, 2015, 2015: 852194.
[38]

SIROTKIN A V, HARRATH A H. Phytoestrogens and their effects[J]. Eur J Pharmacol, 2014, 741: 230-236. doi:  10.1016/j.ejphar.2014.07.057
[39]

LIM S H, HA TY, AHN J, et al. Estrogenic activities of Psoralea corylifolia L. seed extracts and main constituents[J]. Phytomedicine, 2011, 18(5): 425-430. doi:  10.1016/j.phymed.2011.02.002
[40] 蔡心银, 张紫佳. 植物雌激素药理作用及相关中药的研究进展[J]. 现代中药研究与实践, 2020, 34(2): 75-78, 86.
[41] 刘国良, 李建民, 姚远, 等. 补骨脂二氢黄酮甲醚对A375细胞黑素合成的影响[J]. 中医药学报, 2015, 43(6): 9-12. doi:  10.19664/j.cnki.1002-2392.2015.06.004
[42] 刘国良, 于英君, 姚远, 等. 补骨脂二氢黄酮甲醚对A375细胞黑素合成及ER/MAPK信号通路的影响[J]. 中国医药导报, 2015, 12(36): 4-8, 20.
[43]

HILLMER E J, ZHANG H Y, LI H S, et al. STAT3 signaling in immunity[J]. Cytokine Growth Factor Rev, 2016, 31: 1-15. doi:  10.1016/j.cytogfr.2016.05.001
[44]

MATSUDA H, KIYOHARA S, SUGIMOTO S, et al. Bioactive constituents from Chinese natural medicines XXXIII Inhibitors from the seeds of Psoralea corylifolia on production of nitric oxide in lipopolysaccharide-activated macrophages[J]. Biol Pharm Bull, 2009, 32(1): 147-149. doi:  10.1248/bpb.32.147
[45]

SHARMA M L, SINGH B, CHANDAN B K, et al. Actions of some flavonoids on specific and non-specific immune mechanisms[J]. Phytomedicine, 1996, 3(2): 191-195. doi:  10.1016/S0944-7113(96)80035-3
[46]

PAWANKAR R, CANONICA G W, HOLGATE S T, et al. Allergic diseases and asthma: a major global health concern[J]. Curr Opin Allergy Clin Immunol, 2012, 12(1): 39-41. doi:  10.1097/ACI.0b013e32834ec13b
[47]

CHEN X, WEN T, WEI J, et al. Treatment of allergic inflammation and hyperresponsiveness by a simple compound, Bavachinin, isolated from Chinese herbs[J]. Cell Mol Immunol, 2013, 10(6): 497-505. doi:  10.1038/cmi.2013.27
[48]

TINDEMANS I, SERAFINI N, DI SANTO J P, et al. GATA-3 function in innate and adaptive immunity[J]. Immunity, 2014, 41(2): 191-206. doi:  10.1016/j.immuni.2014.06.006
[49]

WANG K, FENG Y P, LI S, et al. Oral delivery of bavachinin-loaded PEG-PLGA nanoparticles for asthma treatment in a murine model[J]. J Biomed Nanotechnol, 2018, 14(10): 1806-1815. doi:  10.1166/jbn.2018.2618
[50]

SATOH T, HOSOKAWA M. Structure function and regulation of carboxylesterases[J]. Chem Biol Interact, 2006, 162(3): 195-211. doi:  10.1016/j.cbi.2006.07.001
[51]

SUN D X, GE G B, DONG P P, et al. Inhibition behavior of fructus psoraleae’s ingredients towards human carboxylesterase 1 (hCES1)[J]. Xenobiotica, 2016, 46(6): 503-510. doi:  10.3109/00498254.2015.1091521
[52]

ZHU X H. Species difference for herb-drug interaction between Fructus psoralea and cardiovascular drug clopidogrel[J]. Lat Am J Pharm, 2016, 35(6): 1473-1475.
[53]

LI Y G, HOU J, LI S Y, et al. Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2[J]. Fitoterapia, 2015, 101: 99-106. doi:  10.1016/j.fitote.2015.01.004
[54]

LALE A, HERBERT J M, AUGEREAU J M, et al. Ability of different flavonoids to inhibit the procoagulant activity of adherent human monocytes[J]. J Nat Prod, 1996, 59(3): 273-276. doi:  10.1021/np960057s
[55] 陈瑞战, 杨思敏, 刘志强, 等. HPLC-ESI-MS快速筛选并鉴定补骨脂甲醇提取物中的抗氧化活性成分[J]. 分子科学学报, 2014, 30(2): 142-146.
[56]

KASSAHUN GEBREMESKEL A, DARSHANA WIJERATHNE T, KIM J H, et al. Psoralea corylifolia extract induces vasodilation in rat arteries through both endothelium-dependent and-independent mechanisms involving inhibition of TRPC3 channel activity and elaboration of prostaglandin[J]. Pharm Biol, 2017, 55(1): 2136-2144. doi:  10.1080/13880209.2017.1383484
[57]

DONG X, ZHU Y, WANG S, et al. Bavachinin inhibits cholesterol synthesis enzyme FDFT1 expression via AKT/mTOR/SREBP-2 pathway[J]. Int Immunopharmacol, 2020, 88: 106865. doi:  10.1016/j.intimp.2020.106865
[58]

DRAGOVIC S, VERMEULEN N P E, GERETS H H, et al. Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man[J]. Arch Toxicol, 2016, 90(12): 2979-3003. doi:  10.1007/s00204-016-1845-1
[59] 季宇彬, 王敏, 王姗, 等. 补骨脂二氢黄酮甲醚诱导HepaRG细胞损伤机制探讨[J]. 中国药理学通报, 2018, 34(4): 544-550. doi:  10.3969/j.issn.1001-1978.2018.04.021
[60]

WANG S, WANG M, WANG M, et al. Bavachinin induces oxidative damage in HepaRG cells through p38/JNK MAPK pathways[J]. Toxins, 2018, 10(4): 154. doi:  10.3390/toxins10040154
[61]

GUO Z J, LI P, WANG C G, et al. Five constituents contributed to the Psoraleae Fructus-induced hepatotoxicity via mitochondrial dysfunction and apoptosis[J]. Front Pharmacol, 2021, 12: 682823. doi:  10.3389/fphar.2021.682823
[62] 朱月, 王姗, 徐丽娇, 等. 基于Label-free技术分析补骨脂二氢黄酮甲醚的肝毒性作用机制[J]. 大理大学学报, 2020, 5(4): 1-6. doi:  10.3969/j.issn.2096-2266.2020.04.001
[63]

WANG X X, LV X, LI S Y, et al. Identification and characterization of naturally occurring inhibitors against UDP-glucuronosyltransferase 1A1 in Fructus Psoraleae (Bu-gu-Zhi)[J]. Toxicol Appl Pharmacol, 2015, 289(1): 70-78. doi:  10.1016/j.taap.2015.09.003
[64]

ZECCA E, DE LUCA D, BARONI S, et al. Bile acid-induced lung injury in newborn infants: a bronchoalveolar lavage fluid study[J]. Pediatrics, 2008, 121(1): e146-e149. doi:  10.1542/peds.2007-1220
[65] 秦子飞, 王培乐, 邢晗, 等. 补骨脂富含的异戊烯基成分对CYP1A1活性的影响及分子对接验证[J]. 南京中医药大学学报, 2021, 37(5): 750-759. doi:  10.14148/j.issn.1672-0482.2021.0750
[66]

LI A, GAO M H, ZHAO N, et al. Acute liver failure associated with Fructus Psoraleae: a case report and literature review[J]. BMC Complement Altern Med, 2019, 19(1): 84. doi:  10.1186/s12906-019-2493-9