留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

丁佳宁,  马进原,  朱全刚

downloadPDF
文章导航 > 药学实践与服务  > 2019 >  37(5): 390-393,421
丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu

长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
  • 1.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437

  • 2.

    上海市皮肤病医院药剂科, 上海 200443

  • 3.

    上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443

基金项目: 国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11）

Research progress of lncRNA MEG3 in tumorigenesis

  • 1.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

  • 2.

    Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 3.

    Department of Pharmacy Laboratory, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China;Department of Pharmacy, Shanghai Dermatology Hospital, Shanghai 200443, China

  • 摘要: 长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。
    Abstract: Long non-coding RNA (lncRNA) covers most of the messages from the human DNA without protein-coding potential,which is a wide range of complicated molecules that consist of more than 90% of the whole genomic and present in different forms in the course of pathophysiology of cancers.In 2003,lncRNA MEG3 was firstly discovered as a potential tumor-inhibiting factor of pituitary adenomas.Later on,the roles and mechanisms in the regulation of gene expression,imprinting,transcription,and post-translation of MEG3 in meningioma,hepatocellular cancer,lung cancer,neuroendocrine tumor,prostate cancer and other kinds of tumors were further clarified,indicated that the expression of MEG3 was down-regulated or deficient in a wide range of tumors while the expression up-regulation of MEG was greatly correlated with tumor inhibition.The function of MEG3 and its research progress in tumorigenesis were summarized in this paper.
  • [1] SANCHEZ CALLE A,KAWAMURA Y,YAMAMOTO Y,et al.Emerging roles of long non-coding RNA in cancer[J].Cancer Sci,2018,109(7):2093-2100.
    [2] KUMAR M M,GOYAL R.LncRNA as a therapeutic target for angiogenesis[J].Curr Top Med Chem,2017,17(15):1750-1757.
    [3] WEIDLE U H,BIRZELE F,KOLLMORGEN G,et al.Long non-coding RNAs and their role in metastasis[J].CGP,2017,14(3):143-160.
    [4] PALMIERI G,PALIOGIANNIS P,SINI M C,et al.Long non-coding RNA CASC2 in human cancer[J].Crit Rev Oncol Hematol,2017,111:31-38.
    [5] BRANNAN C I,DEES E C,INGRAM R S,et al.The product of the H19 gene may function as an RNA[J].Mol Cell Biol,1990,10(1):28-36.
    [6] LI T W,MO X Y,FU L Y,et al.Molecular mechanisms of long noncoding RNAs on gastric cancer[J].Oncotarget,2016,7(8):8601-8612.
    [7] WALLACE C,SMYTH D J,MAISURIA-ARMER M,et al.The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes[J].Nat Genet,2010,42(1):68-71.
    [8] SALLAM T,SANDHU J,TONTONOZ P.Long noncoding RNA discovery in cardiovascular disease:decoding form to function[J].Circ Res,2018,122(1):155-166.
    [9] FENG L,LIAO Y T,HE J C,et al.Plasma long non-coding RNA BACE1 as a novel biomarker for diagnosis of Alzheimer disease[J].BMC Neurol,2018,18(1):4.
    [10] LI H,YU B Q,LI J F,et al.Characterization of differentially expressed genes involved in pathways associated with gastric cancer[J].PLoS One,2015,10(4):e0125013.
    [11] SONG H J,SUN W L,YE G L,et al.Long non——coding RNA expression profile in human gastric cancer and its clinical significances[J].J Transl Med,2013,11:225.
    [12] QIN Y,SUN W,ZHANG H,et al.LncRNA GAS8-AS1 inhibits cell proliferation through ATG5-mediated autophagy in papillary thyroid cancer[J].Endocrine,2018,59(3):555-564.
    [13] ZHANG L G,ZHOU X K,ZHOU R J,et al.Long non-coding RNA LINC00673 promotes hepatocellular carcinoma progression and metastasis through negatively regulating miR-205[J].Am J Cancer Res,2017,7(12):2536-2544.
    [14] ZHANG X,RICE K,WANG Y Y,et al.Maternally expressed gene 3(MEG3) noncoding ribonucleic acid:isoform structure,expression,and functions[J].Endocrinology,2010,151(3):939-947.
    [15] MIYOSHI N,WAGATSUMA H,WAKANA S,et al.Identification of an imprinted gene,Meg3/Gtl2 and its human homologue MEG3,first mapped on mouse distal chromosome 12 and human chromosome 14q[J].Genes Cells,2000,5(3):211-220.
    [16] ZHANG X,ZHOU Y L,MEHTA K R,et al.A pituitary-derived MEG3 isoform functions as a growth suppressor in tumor cells[J].J Clin Endocrinol Metab,2003,88(11):5119-5126.
    [17] ZHAO J,ZHANG X,ZHOU Y L,et al.Cyclic AMP stimulates MEG3 gene expression in cells through a cAMP-response element (CRE) in the MEG3 proximal promoter region[J].Int J Biochem Cell Biol,2006,38(10):1808-1820.
    [18] ZHOU Y L,ZHONG Y,WANG Y Y,et al.Activation of p53 by MEG3 non-coding RNA[J].J Biol Chem,2007,282(34):24731-24742.
    [19] KRUER T L,DOUGHERTY S M,REYNOLDS L,et al.Expression of the lncRNA maternally expressed gene 3(MEG3) contributes to the control of lung cancer cell proliferation by the rb pathway[J].PLoS One,2016,11(11):e0166363.
    [20] GORDON F E,NUTT C L,CHEUNSUCHON P,et al.Increased expression of angiogenic genes in the brains of mouse meg3-null embryos[J].Endocrinology,2010,151(6):2443-2452.
    [21] BENETATOS L,VARTHOLOMATOS G,HATZIMICHAEL E.MEG3 imprinted gene contribution in tumorigenesis[J].Int J Cancer,2011,129(4):773-779.
    [22] BOUCKENHEIMER J,ASSOU S,RIQUIER S,et al.Long non-coding RNAs in human early embryonic development and their potential in ART[J].Hum Reprod Update,2016,23(1):19-40.
    [23] CHEUNSUCHON P,ZHOU Y L,ZHANG X,et al.Silencing of the imprinted DLK1-MEG3 locus in human clinically nonfunctioning pituitary adenomas[J].Am J Pathol,2011,179(4):2120-2130.
    [24] CHUNHAROJRITH P,NAKAYAMA Y,JIANG X B,et al.Tumor suppression by MEG3 lncRNA in a human pituitary tumor derived cell line[J].Mol Cell Endocrinol,2015,416:27-35.
    [25] ZHANG X,GEJMAN R,MAHTA A,et al.Maternally expressed gene 3,an imprinted noncoding RNA gene,is associated with meningioma pathogenesis and progression[J].Cancer Res,2010,70(6):2350-2358.
    [26] BRACONI C,KOGURE T,VALERI N,et al.MicroRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer[J].Oncogene,2011,30(47):4750-4756.
    [27] MODALI S D,PAREKH V I,KEBEBEW E,et al.Epigenetic regulation of the lncRNA MEG3 and its target c-MET in pancreatic neuroendocrine tumors[J].Mol Endocrinol,2015,29(2):224-237.
    [28] LU K H,LI W,LIU X H,et al.Long non-coding RNA MEG3 inhibits NSCLC cells proliferation and induces apoptosis by affecting p53 expression[J].BMC Cancer,2013,13:461.
    [29] RIBARSKA T,BASTIAN K M,KOCH A,et al.Specific changes in the expression of imprinted genes in prostate cancer:implications for cancer progression and epigenetic regulation[J].Asian J Androl,2012,14(3):436-450.
    [30] RIBARSKA T,GOERING W,DROOP J,et al.Deregulation of an imprinted gene network in prostate cancer[J].Epigenetics,2014,9(5):704-717.
    [31] LUO G,WANG M,WU X,et al.Long non-coding RNA MEG3 inhibits cell proliferation and induces apoptosis in prostate cancer[J].Cell Physiol Biochem,2015,37(6):2209-2220.
  • [1] 田硕, 厉建中.  转录因子ZNF24在肿瘤中的研究进展 . 药学实践与服务, 2023, 41(12): 710-713, 721. doi: 10.12206/j.issn.2097-2024.202204043
    [2] 方宇昕, 李育, 刘宝姝, 董国强.  线性泛素连接酶复合体与去线性泛素化酶在肿瘤中的研究进展 . 药学实践与服务, 2023, 41(9): 534-539. doi: 10.12206/j.issn.2097-2024.202307045
    [3] 高习清, 卢光照, 鲁莹, 邹豪.  活性氧自由基响应型脂质体在抗肿瘤研究中的应用进展 . 药学实践与服务, 2023, 41(1): 14-17. doi: 10.12206/j.issn.2097-2024.202105086
    [4] 周许薇, 谭蔚锋, 解方园, 辛宝, 陈俊.  双氢青蒿素抗癌药理作用机制的研究进展 . 药学实践与服务, 2019, 37(3): 206-211,278. doi: 10.3969/j.issn.1006-0111.2019.03.003
    [5] 夏涌, 黄健, 钱其军.  提高CAR-T细胞疗法抗癌活性及安全性的研究进展 . 药学实践与服务, 2016, 34(4): 372-376. doi: 10.3969/j.issn.1006-0111.2016.04.023
    [6] 陈自强, 张玮, 李玉平, 王晓宇.  纳米载药系统逆转肿瘤及骨肉瘤多药耐药的研究进展 . 药学实践与服务, 2016, 34(2): 103-105. doi: 10.3969/j.issn.1006-0111.2016.02.002
    [7] 姜文丽, 黄才国.  晚期非小细胞肺癌靶向治疗的研究进展 . 药学实践与服务, 2016, 34(4): 301-304,333. doi: 10.3969/j.issn.1006-0111.2016.04.004
    [8] 王欢, 佘岚, 王琳召, 马志强, 张欣荣, 杨峰.  氧化介孔碳球纳米粒作为紫杉醇载体的研究 . 药学实践与服务, 2015, 33(2): 114-118. doi: 10.3969/j.issn.1006-0111.2015.02.005
    [9] 王欢, 马志强, 杨峰.  用于肿瘤治疗的小分子干扰RNA非病毒载体研究进展 . 药学实践与服务, 2015, 33(6): 498-501. doi: 10.3969/j.issn.1006-0111.2015.06.005
    [10] 赵心彬, 倪敏, 陶霞.  他汀类药物多效药理作用及其机制研究进展 . 药学实践与服务, 2013, 31(1): 19-21. doi: 10.3969/j.issn.1006-0111.2013.01.005
    [11] 程君, 芮耀诚.  真核延长因子eEF1A功能研究进展 . 药学实践与服务, 2012, 30(2): 89-91,124. doi: 10.3969/j.issn.1006-0111.2012.02.003
    [12] 周忻.  50例肿瘤科住院患者的中药用药情况分析 . 药学实践与服务, 2009, 27(1): 55-57.
    [13] 章忱, 程康, 郭炜, 卫洪昌.  麝香保心丸对裸小鼠人结肠癌肝转移模型促血管新生因子及肿瘤生长的影响 . 药学实践与服务, 2007, (5): 295-296,302.
    [14] 侯雪梅, 崔黎丽, 李国栋, 李卫华.  抗肿瘤药物靶向制剂研究进展 . 药学实践与服务, 2007, (5): 273-275,280.
    [15] 丁力, 丁家崇, 郭葆玉.  抗肿瘤药物新靶点半胱天冬酶-10 . 药学实践与服务, 2006, (2): 76-79.
    [16] 庞晓军, 黄军章, 刘国勇, 李香乐.  肿瘤基因治疗研究进展 . 药学实践与服务, 2006, (1): 4-6.
    [17] 王彦, 刁亚英, 姜远英.  ABC转运蛋白与肿瘤多药耐药 . 药学实践与服务, 2003, (1): 28-31.
    [18] 王晶, 潘勇华, 王旭明, 刘建飞.  光敏剂及其临床应用进展 . 药学实践与服务, 2002, (2): 67-70.
    [19] 范开华, 刘子文, 夏俊.  血卟啉二乙二醇对消化道肿瘤的光动力疗效观察 . 药学实践与服务, 2001, (2): 76-76.
    [20] 范开华, 温定量, 周明惠, 夏俊.  2,7,12,18-四甲基-3,8-二(1-甲氧乙基)-13,17-二(3-乙胺基丙基)卟啉衍生物的合成及其光敏活性 . 药学实践与服务, 1999, (6): 344-346.
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  2634
  • HTML全文浏览量:  271
  • PDF下载量:  575
  • 被引次数: 0
出版历程
  • 收稿日期:  2019-04-04
  • 修回日期:  2019-06-11

长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展

doi: 10.3969/j.issn.1006-0111.2019.05.002
  • 1. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437
  • 2. 上海市皮肤病医院药剂科, 上海 200443
  • 3. 上海中医药大学附属岳阳中西医结合医院药学研究室, 上海 200437;上海市皮肤病医院药剂科, 上海 200443
    • 基金项目:  国家自然科学基金（81472394）；上海市皮肤病医院国家自然科学基金培育项目（17GZRPY11）
  • 收稿日期: 2019-04-04
  • 修回日期: 2019-06-11

摘要: 长链非编码RNA（long non-coding RNA，lncRNA）覆盖了人类DNA的大部分非编码信息，占整个基因组的90%以上，它们构成了一个广泛而复杂的分子群，在肿瘤的病理生理过程中以多种形式存在。2003年，lncRNA人母系表达基因（MEG）3被证明是垂体瘤的一个潜在的肿瘤抑制因子，之后研究者又在脑膜瘤、肝癌、肺癌、神经内分泌瘤，以及前列腺癌等其他肿瘤上对其在基因表达调控、印记、转录和翻译后的作用上进行了研究，发现MEG3在多种恶性肿瘤组织中低表达或表达缺失，而上调MEG3的表达与肿瘤生长抑制相关，其在肿瘤发生中的作用和机制得到了更好地阐明。总结MEG3的功能及在肿瘤发生中的研究进展。

English Abstract

丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
引用本文: 丁佳宁, 马进原, 朱全刚. 长链非编码RNA人母系表达基因3在肿瘤发生中作用的研究进展[J]. 药学实践与服务, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu
DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
Citation: DING Jianing, MA Jinyuan, ZHU Quangang. Research progress of lncRNA MEG3 in tumorigenesis[J]. Journal of Pharmaceutical Practice and Service, 2019, 37(5): 390-393,421. doi: 10.3969/j.issn.1006-0111.2019.05.002
shu

    全文HTML

参考文献 (31)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计