奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析

吴思凡; 谭长宇; 樊红彬; 印晓星; 鲁茜

doi:10.3969/j.issn.1006-0111.2018.04.020

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奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析

吴思凡, 谭长宇, 樊红彬, 印晓星, 鲁茜

文章导航 > 药学实践与服务 > 2018 > 36(4): 373-378

吴思凡, 谭长宇, 樊红彬, 印晓星, 鲁茜. 奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析[J]. 药学实践与服务, 2018, 36(4): 373-378. doi: 10.3969/j.issn.1006-0111.2018.04.020

引用本文:

WU Sifan, TAN Changyu, FAN Hongbin, YIN Xiaoxing, LU Qian. A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 373-378. doi: 10.3969/j.issn.1006-0111.2018.04.020

Citation:

WU Sifan, TAN Changyu, FAN Hongbin, YIN Xiaoxing, LU Qian. A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 373-378. doi: 10.3969/j.issn.1006-0111.2018.04.020

奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析

doi: 10.3969/j.issn.1006-0111.2018.04.020

1.
徐州医科大学江苏省新药研究与临床药学重点实验室, 江苏徐州 221004
2.
徐州医科大学附属医院神经内科, 江苏徐州 221006

A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy

1.
Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
2.
Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China

摘要: 目的系统评价奥卡西平与卡马西平治疗脑卒中后继发性癫痫的疗效和安全性。方法计算机检索PubMed、Cochrane Library、EMbase、万方、中国知网、维普、中国生物医学文献数据库（CBM）等收录的奥卡西平和卡马西平治疗脑卒中后继发性癫痫的相关文献，检索时限为建库以来到2017年8月，使用RevMan5.3软件进行Meta分析。结果共纳入6项研究，包含517例患者。Meta分析结果显示：奥卡西平组控制癫痫的总体有效率高于卡马西平组，差异有统计学意义（RR=1.44，95%CI：1.29~1.60，P<0.000 01）；奥卡西平组总不良反应发生率低于卡马西平组，差异有统计学意义（RR=0.39，95%CI：0.26~0.57，P<0.000 01）；皮疹、头晕、嗜睡、恶心、呕吐发生率的比较差异均无统计学意义。结论奥卡西平治疗脑卒中后继发性癫痫的疗效优于卡马西平，安全性较卡马西平好。由于本研究纳入的文献数量和样本量较少，因此还需更多大样本、多中心的高质量临床随机对照试验（randomized controlled trials，RCT）进一步研究验证。
- 奥卡西平 /
- 卡马西平 /
- 脑卒中后继发性癫痫 /
- 疗效 /
- 安全性 /
- Meta分析
Abstract: Objective To evaluate the efficacy and safety of oxcarbazepine and carbamazepine in treating post-stroke epilepsy. Methods PubMed, Cochrane Library, EMbase, VIP, CNKI and CBM were used for searching literatures related to oxcarbazepine and carbamazepine in the treatment of post-stroke epilepsy before August 2017, followed with RevMan5.3 software for data analysis. Results 6 studies were included with 517 patients. Meta-analysis showed that the total effective rate in oxcarbazepine group was higher than carbamazepine group with statistical significance (RR=1.44,95%CI:1.29~1.60,P<0.000 01). The incidence of total adverse reactions in oxcarbazepine group was also statistically significant lower than carbamazepine group (RR=0.39,95%CI:0.26~0.57,P<0.000 01). There was no statistically significant difference (P>0.05) in rash, dizziness, somnolence, nausea and vomiting between two groups. Conclusion Our analysis indicated that oxcarbazepine had better efficacy than carbamazepine in treating post-stroke epilepsy with less adverse reactions. Due to the limited number of literatures and sample size, large samples with multi-center and high quality clinical randomized controlled trials are needed to confirm the credibility of our conclusions.
- oxcarbazepine /
- carbamazepine /
- post-stroke epilepsy /
- efficacy /
- safety /
- Meta-analysis

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[8]	王艳,赵新利,吴新艳,等. 奥卡西平与卡马西平治疗脑卒中后继发性癫痫疗效比较[J].新乡医学院学报,2014,31(4):312-314.
[9]	韦韬,邱小鹰,陈红,等. 奥卡西平与卡马西平在脑卒中后继发性癫痫的疗效观察[J]. 医学信息,2016,29(9):267-267.
[10]	SZOEKE CE,NEWTON M,WOOD JM,et al. Update on pharmacogenetics in epilepsy:a brief review[J]. Lancet Neurol,2006,5(2):189-196.
[11]	BOOTSMA HP,RICKER L,DIEPMAN L,et al. Levetiracetam in clinical practice:long-term experience in patients with refractory epilepsy referred to a tertiary epilepsy center[J]. Epilepsy Behav,2007,10(2):296-303.
[12]	ROUAN MC,LECAILLON JB,GODBILLON J,et al. The effect of renal impairment on the pharmacokinetics of oxcarbazepine and its metabolites[J]. Eur J Clin Pharmacol,1994,47(2):161-167.
[13]	ANTUNES NJ,VAN DIJKMAN SC,LANCHOTE VL,et al. Population pharmacokinetics of oxcarbazepine and its metabolite 10-hydroxycarbazepine in healthy subjects[J]. Eur J Pharm Sci,2017,109S:S116-S123.
[14]	RYVLIN P,MONTAVONT A,NIGHOGHOSSIAN N. Optimizing therapy of seizures in stroke patients[J]. Neurology,2006,67(4):3-9.

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奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析

doi: 10.3969/j.issn.1006-0111.2018.04.020

1. 徐州医科大学江苏省新药研究与临床药学重点实验室, 江苏徐州 221004

2. 徐州医科大学附属医院神经内科, 江苏徐州 221006

收稿日期: 2017-10-19
修回日期: 2018-03-26

关键词:

奥卡西平 /

卡马西平 /

脑卒中后继发性癫痫 /

疗效 /

安全性 /

Meta分析

摘要: 目的系统评价奥卡西平与卡马西平治疗脑卒中后继发性癫痫的疗效和安全性。方法计算机检索PubMed、Cochrane Library、EMbase、万方、中国知网、维普、中国生物医学文献数据库（CBM）等收录的奥卡西平和卡马西平治疗脑卒中后继发性癫痫的相关文献，检索时限为建库以来到2017年8月，使用RevMan5.3软件进行Meta分析。结果共纳入6项研究，包含517例患者。Meta分析结果显示：奥卡西平组控制癫痫的总体有效率高于卡马西平组，差异有统计学意义（RR=1.44，95%CI：1.29~1.60，P<0.000 01）；奥卡西平组总不良反应发生率低于卡马西平组，差异有统计学意义（RR=0.39，95%CI：0.26~0.57，P<0.000 01）；皮疹、头晕、嗜睡、恶心、呕吐发生率的比较差异均无统计学意义。结论奥卡西平治疗脑卒中后继发性癫痫的疗效优于卡马西平，安全性较卡马西平好。由于本研究纳入的文献数量和样本量较少，因此还需更多大样本、多中心的高质量临床随机对照试验（randomized controlled trials，RCT）进一步研究验证。

English Abstract

A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy

1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China

2. Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China

Received Date: 2017-10-19
Rev Recd Date: 2018-03-26

Keywords:

Abstract: Objective To evaluate the efficacy and safety of oxcarbazepine and carbamazepine in treating post-stroke epilepsy. Methods PubMed, Cochrane Library, EMbase, VIP, CNKI and CBM were used for searching literatures related to oxcarbazepine and carbamazepine in the treatment of post-stroke epilepsy before August 2017, followed with RevMan5.3 software for data analysis. Results 6 studies were included with 517 patients. Meta-analysis showed that the total effective rate in oxcarbazepine group was higher than carbamazepine group with statistical significance (RR=1.44,95%CI:1.29~1.60,P<0.000 01). The incidence of total adverse reactions in oxcarbazepine group was also statistically significant lower than carbamazepine group (RR=0.39,95%CI:0.26~0.57,P<0.000 01). There was no statistically significant difference (P>0.05) in rash, dizziness, somnolence, nausea and vomiting between two groups. Conclusion Our analysis indicated that oxcarbazepine had better efficacy than carbamazepine in treating post-stroke epilepsy with less adverse reactions. Due to the limited number of literatures and sample size, large samples with multi-center and high quality clinical randomized controlled trials are needed to confirm the credibility of our conclusions.

引用本文:

Citation:

WU Sifan, TAN Changyu, FAN Hongbin, YIN Xiaoxing, LU Qian. A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(4): 373-378. doi: 10.3969/j.issn.1006-0111.2018.04.020

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奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析

doi: 10.3969/j.issn.1006-0111.2018.04.020

A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy

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奥卡西平和卡马西平治疗脑卒中后继发性癫痫疗效与安全性的Meta分析

doi: 10.3969/j.issn.1006-0111.2018.04.020

1. 徐州医科大学江苏省新药研究与临床药学重点实验室, 江苏 徐州 221004 2. 徐州医科大学附属医院神经内科, 江苏 徐州 221006

English Abstract

A Meta-analysis for the evaluation of efficacy and safety of oxcarbazepine and carbamazepine for post-stroke epilepsy

1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China 2. Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China

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目录

1. 徐州医科大学江苏省新药研究与临床药学重点实验室, 江苏徐州 221004

2. 徐州医科大学附属医院神经内科, 江苏徐州 221006

1. Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou 221004, China

2. Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221006, China