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抑郁症致病机制及中药治疗抑郁症的机制研究

姚媛,  周艺,  周婷婷

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文章导航 > 药学实践与服务  > 2018 >  36(3): 193-197
姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
引用本文: 姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu
YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
Citation: YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu

抑郁症致病机制及中药治疗抑郁症的机制研究

doi: 10.3969/j.issn.1006-0111.2018.03.001
  • 1.

    安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433

  • 2.

    94826部队医院内科, 上海 200433

  • 3.

    第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433

基金项目: 国家自然科学基金资助项目（81573584，81773862）

Pathogenesis of depression and the mechanism research in TCM treatment of major depression

  • 1.

    School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai Key Laboratory for Pharmaceutical Metabolites Research, Shanghai 200433, China

  • 2.

    Medical Department of 94826 Military Hospital, Shanghai 200433, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China;Shanghai Key Laboratory for Pharmaceutical Metabolites Research, Shanghai 200433, China

  • 摘要: 抑郁症严重危害人类身心健康，世界卫生组织预测：2020年抑郁症将成为非正常死亡和残疾的第二大原因。目前临床上大多使用三环类抗抑郁药（TCA）、四环类抗抑郁药、选择性5-HT再摄取抑制药等来治疗抑郁症，但长期应用这类药物易产生耐药性，不良反应明显，且这种通过单一成分阻断特定单一靶点的药物，对于涉及体内多个系统的生物学异常往往难以达到治疗效果。中药组方通过其所包含的多组分能同时调节多靶点、调节疾病网络的多个环节，在获得较高疗效的同时可降低化学药单靶点引起的毒副作用，且目前国内外对一些传统中药抗抑郁作用机制的研究报道也日渐增多，主要集中在神经递质水平释放、海马脑源性神经营养因子（BDNF）表达及细胞因子等方面。此外，最新的研究认为肠道菌群可能参与了从情感性疾病到神经系统疾病的发生发展。综述近年来中药抗抑郁神经保护作用的机制研究进展，以期为抑郁症发病机制探讨及抗抑郁药物研究提供借鉴和指导。
    Abstract: Depression is a serious health hazard and the World Health Organization predicts that depression will be the second leading cause of abnormal death and disability by 2020. Currently, most antidepressants are tricyclic antidepressants (TCA), tetracyclic antidepressants and selective 5-HT reuptake inhibitors. Long term use of those medications will develop resistance and adverse reactions. In addition, drugs that block a single target are often hard to achieve therapeutic outcomes due to the biological abnormalities involving multiple systems in the body. Traditional Chinese Medicine (TCM) can simultaneously act on multiple targets to influence the disease network in many aspects at the same time. This approach has higher efficacy and lower side effects than a single chemical medication. Recently, there are increasing numbers of research papers on antidepressant mechanism of TMC, mainly focused on the release level of neurotransmitters, hippocampus brain derived neurotrophic factor (BDNF) expression and cytokines, etc. The latest researches also indicated that the gut microbiota has involved the development of emotional diseases and the diseases related to central nerves system. This paper reviews the mechanism studies of TMC as antidepressants and neuroprotection agents in order to shed new light on the study of depression pathogenesis and development of new antidepressant medications.
  • [1] Sayers J. The world health report 2001-Mental health:new understanding,new hope[J]. Bullet World Health Organ,2001,79(11):1085.
    [2] Zhang X, Tian JS, Liu H, et al. Progress of new antidepressant drugs development[J]. Chin J Chin Mater Medic, 2017, 42(1):29-33.
    [3] 王旭东, 乔明琦, 张樟进,等. 中医药治疗抑郁症的研究进展[J]. 南京中医药大学学报, 2016, 32(1):93-96.
    [4] Adam Samuels B, Leonardo ED, Hen R. Hippocampal subfields and major depressive disorder[J]. Biol Psychiatry, 2015, 77(3):210-211.
    [5] Schoenfeld TJ, Mccausland HC, Morris HD, et al. Stress and loss of adult nurogenesis differentially reduce hippocampal volume[J]. Bioll Psychiatry, 2017,82(12):914-923.
    [6] Hill AS, Sahay A, Hen R. Increasing adult hippocampal neurogenesis is sufficient to reduce anxiety and depression-like behaviors[J]. Neuropsychopharmacology, 2015, 40(10):2368-2378.
    [7] Bremner JD, Narayan M, Anderson ER, et al. Hippocampal volume reduction in major depression[J]. Am J Psychiatry, 2000, 157(1):115-118.
    [8] Moraitis AG, Block T, Nguyen D, et al. The role of glucocorticoid receptors in metabolic syndrome and psychiatric illness[J]. J Steroid Biochem Mol Biol, 2017, 165:114-120.
    [9] 张国双, 杨坤. 抗抑郁新靶点-糖皮质激素受体[J]. 国际精神病学杂志, 2015,42(1):84-86.
    [10] Kinlein SA, Wilson CD, Karatsoreos IN. Dysregulated hypothalamic-pituitary-adrenal axis function contributes to altered endocrine and neurobehavioral responses to acute stress[J]. Front Psychiatry, 2015, 6:31.
    [11] Ferrari F, Villa RF. The neurobiology of depression:an integrated overview from biological theories to clinical evidence[J]. Mol Neurobiol,2017,54(7):4847-4865.
    [12] 乔卉, 安书成, 徐畅. BDNF与抑郁症的研究现状及进展[J]. 生理科学进展, 2011, 42(3):195-200.
    [13] Rantamaki T, Yalcin I. Antidepressant drug action-from rapid changes on network function to network rewiring[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2016, 64:285-292.
    [14] Schmitt K, Holsboer-Trachsler E, Eckert A. BDNF in sleep, insomnia, and sleep deprivation[J]. Ann Med, 2016, 48(1-2):42-51.
    [15] Hauser SR, Getachew B, Taylor RE, et al. Alcohol induced depressive-like behavior is associated with a reduction in hippocampal BDNF[J]. Pharmacol Biochem Behav, 2011, 100(2):253-258.
    [16] Zhuang F, Zhou X, Gao X, et al. Cytokines and glucocorticoid receptors are associated with the antidepressant-like effect of alarin[J]. Peptides, 2016, 76:115-129.
    [17] Felger JC, Lotrich FE. Inflammatory cytokines in depression:neurobiological mechanisms and therapeutic implications[J]. Neuroscience, 2013, 246(5):199-229.
    [18] Su WJ, Cao ZY, Jiang CL. Inflammatory mechanism of depression and its new strategy for diagnosis and treatment[J].Sheng Li Xue Bao,2017,69(5):715-722.
    [19] 汪崇泽, 盛国红. 免疫炎症途径与抑郁症的研究进展[J]. 精神医学杂志, 2015,28(5):397-400.
    [20] Zhu X, Han Y, Du J, et al. Microbiota-gut-brain axis and the central nervous system[J]. Oncotarget, 2017, 8(32):53829-53838.
    [21] 于林, 胡号应, 丁国安,等. 肠道微生物在抑郁症发病中的作用及其研究进展[C].2016中华中医药学会神志病分会学术年会,2016.
    [22] Zheng P, Zeng B, Zhou C, et al. Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host's metabolism[J]. Mol Psychiatry, 2016, 21(6):786-796.
    [23] Zhang QX,Ma XL,Yang Y, et al. Jieyuanshen decoction exerts antidepressant effects on depressive rat model via regulating hpa axis and the level of amino acids neurotransmitter[J]. Afric J Tradit,Complement Altern Med,2017, 14(2):33-46.
    [24] 刘婉婉, 许璐, 董宪喆,等. 开心散类方对慢性应激大鼠行为学及中枢单胺类神经递质的影响[J]. 中国中药杂志, 2015, 40(11):2180-2185.
    [25] Dong XZ, Li ZL, Zheng XL, et al. A representative prescription for emotional disease, Ding-Zhi-Xiao-Wan restores 5-HT system deficit through interfering the synthesis and transshipment in chronic mild stress-induced depressive rats[J]. J Ethnopharmacol, 2013, 150(3):1053-1061.
    [26] Gong MJ, Han B, Wang SM, et al. Icariin reverses corticosterone-induced depression-like behavior, decrease in hippocampal brain-derived neurotrophic factor (BDNF) and metabolic network disturbances revealed by NMR-based metabonomics in rats[J]. J Pharm Biomed Anal, 2016, 123:63-73.
    [27] Ye YL,Zhong K, Liu DD, et al. Huanglian-Jie-Du-Tang extract ameliorates depression-like behaviors through BDNF-TrkB-CREB pathway in rats with chronic unpredictable stress[J]. Evidence-Based Complement Altern Med,2017(4):1-13.
    [28] Chen CY, Yeh YW, Kuo SC, et al. Differences in immunomodulatory properties between venlafaxine and paroxetine in patients with major depressive disorder[J]. Psychoneuroendocrinology, 2017, 87:108-118.
    [29] An L, Li J,Yu ST, et al. Effects of the total flavonoid extract of Xiao bu xin-Tang on depression-like behavior induced by lipopolysaccharide and proinflammatory cytokine levels in mice[J]. J Ethnopharmacol, 2015, 163:83-87.
    [30] Qiu JJ, Liu Z, Zhao P, et al. Gut microbial diversity analysis using Illumina sequencing for functional dyspepsia with liver depression-spleen deficiency syndrome and the interventional Xiaoyaosan in a rat model[J]. World J Gastroenterol, 2017, 23(5):810-816.
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  • 收稿日期:  2017-12-19
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抑郁症致病机制及中药治疗抑郁症的机制研究

doi: 10.3969/j.issn.1006-0111.2018.03.001
  • 1. 安徽中医药大学药学院, 安徽 合肥 230012;第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433
  • 2. 94826部队医院内科, 上海 200433
  • 3. 第二军医大学药学院, 上海 200433;上海市药物(中药)代谢产物研究重点实验室, 上海 200433
    • 基金项目:  国家自然科学基金资助项目（81573584，81773862）
  • 收稿日期: 2017-12-19
  • 修回日期: 2018-01-22

摘要: 抑郁症严重危害人类身心健康，世界卫生组织预测：2020年抑郁症将成为非正常死亡和残疾的第二大原因。目前临床上大多使用三环类抗抑郁药（TCA）、四环类抗抑郁药、选择性5-HT再摄取抑制药等来治疗抑郁症，但长期应用这类药物易产生耐药性，不良反应明显，且这种通过单一成分阻断特定单一靶点的药物，对于涉及体内多个系统的生物学异常往往难以达到治疗效果。中药组方通过其所包含的多组分能同时调节多靶点、调节疾病网络的多个环节，在获得较高疗效的同时可降低化学药单靶点引起的毒副作用，且目前国内外对一些传统中药抗抑郁作用机制的研究报道也日渐增多，主要集中在神经递质水平释放、海马脑源性神经营养因子（BDNF）表达及细胞因子等方面。此外，最新的研究认为肠道菌群可能参与了从情感性疾病到神经系统疾病的发生发展。综述近年来中药抗抑郁神经保护作用的机制研究进展，以期为抑郁症发病机制探讨及抗抑郁药物研究提供借鉴和指导。

English Abstract

姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
引用本文: 姚媛, 周艺, 周婷婷. 抑郁症致病机制及中药治疗抑郁症的机制研究[J]. 药学实践与服务, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu
YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
Citation: YAO Yuan, ZHOU Yi, ZHOU Tingting. Pathogenesis of depression and the mechanism research in TCM treatment of major depression[J]. Journal of Pharmaceutical Practice and Service, 2018, 36(3): 193-197. doi: 10.3969/j.issn.1006-0111.2018.03.001
shu

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