Pharmacoeconomic evaluation on three different anti-hypertensive treatments
-
摘要: 目的 应用药物经济学原理评价3种降压治疗方案,并找出最佳给药方案。 方法 采用回顾性分析法,收集金华市中心医院120例高血压患者,分为3组,A组给予福辛普利钠片,B组给予缬沙坦胶囊,C组给予苯磺酸氨氯地平,疗程均为8周,观察患者的临床疗效并进行最小成本分析。 结果 A、B、C 3组的有效率分别为90.7%、92.3%、92.1%,3组间无显著性差异(P>0.05)。3组的不良反应发生率分别为16.7%、7.7%、13.2%(P>0.05)。3组的人均总成本分别为287.3元、378.7元、320.4元(P<0.05)。 结论 3组方案的疗效相似,从经济学角度来说,福辛普利钠(A组)的成本效果比最优。Abstract: Objective To compare three different anti-hypertension therapeutic projects by pharmacoeconomic evaluation and to find out the best therapeutic project. Methods Retrospective study was used.120 patients with hypertension were randomly assigned to group A (fosinopril sodium),group B(valsartan),group C(amlodipine besylate tablet),the therapeutic effects were observed and were evaluated by cost minimization analysis. Results The total efficiency of A,B,C group were 90.7%, 92.3%, 92.1% (P>0.05) respectively. The incidence of adverse reaction were 16.7%,7.7%,13.2%(P>0.05) respectively. The costs were 287.3 yuan, 378.7 yuan and 320.4 yuan respectively. Conclution The effectiveness of the three groups was similar. In terms of pharmacoeconomics, group A was the best therapeutic project.
-
Key words:
- fosinopril sodium /
- valsartan /
- amlodipine besylate tablet /
- cost minimization analysis
-
[1] O'Shea PM,Griffin TP,Fitzgibbon M. Hypertension:the role of biochemistry In the diagnosis and management[J].Clin Chim Acta,2017,465:131-143. [2] 杨春娥,张三奇,石玉,等.近年来高血压病药物及其综合治疗的概述[J].心脏杂志,2002,14(6):550-551. [3] Cesari M,Pedone C,Incalzi RA,et al. ACE-inhibition and physical function:results from the Trial of Angiotensin-Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study[J]. J Am Med Dir Assoc,2010,11(1):26-32. [4] Cesari M,Kritchevsky SB,Atkinson HH,et al. Angiotensin-converting enzyme inhibition and novel cardiovascular risk biomarkers:Results from the Trial of Angiotensin Converting Enzyme Inhibition and Novel Cardiovascular Risk Factors (TRAIN) study[J].Am Heart J,2009,157(2):1-8. [5] Lim SY,Kim SW,Kim EJ,et al. Telmisartan versus valsartan in patients with hypertension:effects on cardiovascular, metabolic, and inflammatory parameters[J]. Kor Circul J,2011, 41(10):583. [6] 曾晓勤.小剂量氨氯地平联合用药治疗高血压的疗效和安全性评价[J].中华临床医师杂志(电子版),2016,10(4):33-34.
计量
- 文章访问数: 2978
- HTML全文浏览量: 350
- PDF下载量: 912
- 被引次数: 0