Evaluation of hypoglycemic drug-drug interactions by software
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摘要: 目的 评价并分析不同降糖药物的药物相互作用（DDI）。 方法 将目前临床上常用的降糖药物（包括胰岛素和27种非胰岛素制剂）使用DDI数据库Lexi-InteractionTM分析评价其DDI并进行归纳和排序。 结果 28种药物共涉及DDI数量882种，其中C级最多（69.8%），C、D、X级占总数的91.2%，其中X级为28种。平均每种药物DDI数量最多的为磺脲类药物，其次为二甲双胍，最少的为α-糖苷酶抑制剂。 结论 对于合并用药较多、老年患者及肝肾功能不全者应优先选用DDI数量较少的降糖药物，如α-糖苷酶抑制剂、胰高血糖素样肽-1（GLP-1）类似物、钠-葡萄糖共转运蛋白2抑制剂（SGLT2i）等。Abstract: Objective To evaluate and analyze the drug-drug interactions (DDI) of different antidiabetic drugs. Methods DDI database Lexi-InteractionTM was used to evaluate DDI for 28 commonly used antidiabetic medications (including insulin and 27 non-insulin preparations). Results 882 DDIs were identified for 28 drugs. Category C was the top rated DDI (69.8%). Category C, D, X were accounted for 91.2% of the total DDI. 28 medication combinations belonged to category X, which should be avoided to use together. Sulfonylureas had the most DDI, followed by metformin. Alpha-glucosidase inhibitors had least DDI. Conclusion Hypoglycemic drugs with less DDI, such as α-glycosidase inhibitors, glucagon-likepeptide1(GLP-1)analogs and sodium-dependent glucose transporters 2 inhibitor (SGLT2i)should be considered with high priority for patients taking multiple antidiabetic medications, elderly patients and patients with liver-kidney dysfunction.
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Key words:
- hypoglycemic drugs /
- drug-drug interactions (DDI) /
- evaluation by software
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