Intervention and prevention against irrational medication orders on antineoplastic drugs and total parenteral nutrition solution
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摘要: 目的 收集并分析第二军医大学附属东方肝胆外科医院静脉药物配置中心(PIVAS)的不合理医嘱,为临床合理用药提供参考。 方法 采用回顾性分析方法,对本院2016年1月-12月PIVAS的不合理医嘱进行统计分析。 结果 2016年1月-12月本院PIVAS共处理医嘱39 948条,其中抗肿瘤药的不合理医嘱134条(0.33%),肠外营养液(TPN)的不合理医嘱222条(0.56%)。对不合理医嘱按原因分类:溶媒用量不合理、营养液成分配比不合理、药物剂量不合理、配伍禁忌、溶媒选择不合理,分别为19、222、95、12、8例,发生率分别为5.34%、62.36%、26.69%、3.37%、2.24%。 结论 通过药师对临床不合理医嘱的干预和防范,大大降低了临床用药的风险,从而保证临床用药的安全性和有效性。Abstract: Objective To study the irrational intravenous (IV) medication orders and promote rational medication applications. Methods A retrospective analysis was conducted to analyze the irrational prescriptions from January to December 2016. Results Among 39 948 IV medication orders reviewed, there were 134 irrational prescriptions of cytotoxic drugs (0.33%) and 222 irrational prescriptions of total parenteral nutrition(TPN)(0.56%).Within 356 irrational prescriptions, 19 had improper amount of diluent(5.34%), 95 inappropriate dosage(26.69%), 12 drug incompatibility(3.37%), 8 wrong diluent (2.24%) and 222 inappropriate TPN orders (62.36%). Conclusion The interventions of the clinical pharmacists are needed to reduce medication errors and improve the drug safety and effectiveness.
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