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心脑血管疾病的治疗新策略：激活压力感受性反射

张丽丽,  刘爱军,  陈磊,  宋洪涛

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张丽丽, 刘爱军, 陈磊, 宋洪涛. 心脑血管疾病的治疗新策略：激活压力感受性反射[J]. 药学实践与服务, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
引用本文: 张丽丽, 刘爱军, 陈磊, 宋洪涛. 心脑血管疾病的治疗新策略：激活压力感受性反射[J]. 药学实践与服务, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
shu
ZHANG Lili, LIU Aijun, CHEN Lei, SONG Hongtao. New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
Citation: ZHANG Lili, LIU Aijun, CHEN Lei, SONG Hongtao. New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
shu

心脑血管疾病的治疗新策略：激活压力感受性反射

doi: 10.3969/j.issn.1006-0111.2017.04.002
  • 1.

    福州总医院药学科, 福建 福州 350025

  • 2.

    第二军医大学药学院药理学教研室, 上海 200433

New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy

  • 1.

    Department of Pharmacy, Fuzhou General Hospital, Fuzhou 350025, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 我国心脑血管疾病的发病人数和死亡人数持续升高，动脉压力感受性反射（arterial baroreflex， ABR）功能受损与许多心脑血管疾病（如高血压、心衰等）的发生、发展密切相关。美国CVRx公司研发的Barostim neoTM仪器可以实现慢性刺激颈动脉窦处的压力感受器，激活压力反射，从而降低血压和心率，用于治疗顽固性高血压、心衰、终末期肾损伤等疾病。其治疗疾病的主要机制是抑制交感神经系统和肾素-血管紧张素系统，增强迷走神经的活动，进而改善压力感受性反射敏感性（baroreflex sensitivity， BRS）和心率变异性，恢复关键脏器的结构和功能。
    Abstract: The incident number and death toll of cardio-cerebrovascular diseases increase continuously in China. The impairment of arterial baroreflex (ABR) is closely related to the genesis and development of cardio-cerebrovascular diseases (such as hypertension and chronic heart failure). Barostim neoTM (by American CRVx. Inc) can reduce blood pressure and heart rate by electrically stimulating carotid sinus baroreceptors and activating baroreflex. Therefore, it can be used to treat resistant hypertension, heart failure and end-stage renal disease, etc. The mechanism of baroreflex activation therapy (BAT) includes inhibiting sympathetic nervous system and rennin-angiotensin system, and increasing the activity of vagus nerve. Thus it improves baroreflex sensitivity and heart rate variability, and restores the structure and function of key organs.
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  • 收稿日期:  2016-12-26
  • 修回日期:  2017-03-20

心脑血管疾病的治疗新策略：激活压力感受性反射

doi: 10.3969/j.issn.1006-0111.2017.04.002
  • 1. 福州总医院药学科, 福建 福州 350025
  • 2. 第二军医大学药学院药理学教研室, 上海 200433
  • 收稿日期: 2016-12-26
  • 修回日期: 2017-03-20

摘要: 我国心脑血管疾病的发病人数和死亡人数持续升高，动脉压力感受性反射（arterial baroreflex， ABR）功能受损与许多心脑血管疾病（如高血压、心衰等）的发生、发展密切相关。美国CVRx公司研发的Barostim neoTM仪器可以实现慢性刺激颈动脉窦处的压力感受器，激活压力反射，从而降低血压和心率，用于治疗顽固性高血压、心衰、终末期肾损伤等疾病。其治疗疾病的主要机制是抑制交感神经系统和肾素-血管紧张素系统，增强迷走神经的活动，进而改善压力感受性反射敏感性（baroreflex sensitivity， BRS）和心率变异性，恢复关键脏器的结构和功能。

English Abstract

张丽丽, 刘爱军, 陈磊, 宋洪涛. 心脑血管疾病的治疗新策略：激活压力感受性反射[J]. 药学实践与服务, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
引用本文: 张丽丽, 刘爱军, 陈磊, 宋洪涛. 心脑血管疾病的治疗新策略：激活压力感受性反射[J]. 药学实践与服务, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
shu
ZHANG Lili, LIU Aijun, CHEN Lei, SONG Hongtao. New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
Citation: ZHANG Lili, LIU Aijun, CHEN Lei, SONG Hongtao. New strategy for cardio-cerebrovascular diseases: baroreflex activation therapy[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(4): 294-297,345. doi: 10.3969/j.issn.1006-0111.2017.04.002
shu

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