孟鲁司特钠水溶液的胶束性质研究

鄢寒; 黄月英; 沈一唯; 石晓晴; 卞俊

doi:10.3969/j.issn.1006-0111.2017.01.009

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

孟鲁司特钠水溶液的胶束性质研究

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊

文章导航 > 药学实践与服务 > 2017 > 35(1): 36-38,66

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

引用本文:

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

Citation:

YAN Han, HUANG Yueying, SHEN Yiwei, SHI Xiaoqing, BIAN Jun. Study on the micelle properties of montelukast sodium in aqueous solution[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

孟鲁司特钠水溶液的胶束性质研究

doi: 10.3969/j.issn.1006-0111.2017.01.009

1.
解放军411医院药学科, 上海 200434;江西中医药大学药学院, 江西南昌 330004
2.
解放军411医院药学科, 上海 200434

Study on the micelle properties of montelukast sodium in aqueous solution

1.
Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
2.
Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China

摘要: 目的研究具有表面活性的药物孟鲁司特钠的水溶液性质，为其开发成胶束及其相关制剂提供实验依据。方法用电导法测定孟鲁司特钠的临界胶束浓度（critical micelle concentration， CMC）并考察温度对CMC的影响；用紫外-可见光分光光度法测定不同浓度孟鲁司特钠水溶液的透光率，并考察加入不同浓度氯化钠对吸光度和透光率的影响；高速离心法考察孟鲁司特钠水溶液形成胶束后的稳定性。结果孟鲁司特钠在25℃、30℃、35℃的CMC分别为0.75、0.82、0.90 mmol/L；氯化钠对孟鲁司特钠水溶液吸光度和透光率的影响不仅与氯化钠的浓度有关，还与孟鲁司特钠溶液的自身浓度有关；当孟鲁司特钠水溶液浓度>7.5 mmol/L时可得到澄清溶液且高速离心无沉淀。结论孟鲁司特钠为具有表面活性作用的药物，其水溶液的胶束性质易受温度和电解质的影响，可利用此性质将其开发为胶束或混合胶束制剂。
- 孟鲁司特钠 /
- 表面活性 /
- 临界胶束浓度 /
- 吸光度 /
- 透光率 /
- 稳定性
Abstract: Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.
- montelukast sodium /
- surface active /
- CMC /
- absorbance /
- transmittance /
- stability

[1]	李国胜, 王海燕, 杨红娟.孟鲁司特钠片的循证应用[J].山西医药杂志, 2016, 45(10):1174-1178.
[2]	Kabir-Ud-Din, Al-Ahmadi MD, Naqvi AZ, et al. Conductometric study of antidepressant drug-cationic surfactant mixed micelles in aqueous solution[J]. Colloids Surf B:Biointerfaces, 2008, 64(1):65-69.
[3]	韩丽梅, 王卓, 邓英杰,等.用透光率评价分散片混悬性的方法[J].药物分析杂志, 1996,16(6):396-397.
[4]	赵国玺.表面活性剂物理化学[M]. 北京:北京大学出版社, 1991:190-192.
[5]	Attwood DT.Surfactant Systems Their Chemistry, Pharmacy and Biology[M]. London:Chapman & Hall,1983:72-117.
[6]	Causon D, Gettins J, Gormally J, et al.Ultrasonic relaxations associated with aggregation in drugs[J]. J Chem Soc Faraday Trans, 1981, 77(1):143-151.

[1]	龚亚, 李敏, 曹健, 樊莉. 高效液相色谱法考察8种常用对照品溶液的稳定性 . 药学实践与服务, 2021, 39(5): 426-430. doi: 10.12206/j.issn.1006-0111.202101025
[2]	陶春, 吴博, 黄爱文, 王天宇, 王佳琳, 宋洪涛. 复方酮康唑软膏的制备与稳定性考察 . 药学实践与服务, 2017, 35(6): 535-538,550. doi: 10.3969/j.issn.1006-0111.2017.06.013
[3]	林小明, 韦宝含, 曾毅, 韦平原, 梁汉钦, 谢伟乾, 陈明忠. 注射用硝普钠在2种溶媒中的稳定性考察 . 药学实践与服务, 2015, 33(1): 63-64,93. doi: 10.3969/j.issn.1006-0111.2015.01.017
[4]	常银龙, 肖良, 郑杰民, 王倩倩, 张黎明. 发形霞水母触手提取物的蛋白稳定性及其溶血活性 . 药学实践与服务, 2014, 32(6): 434-439. doi: 10.3969/j.issn.1006-0111.2014.06.009
[5]	彭贤东, 龙凤, 唐志立, 谢军. 替硝唑螺内酯乳膏稳定性研究 . 药学实践与服务, 2013, 31(4): 290-292,299. doi: 10.3969/j.issn.1006-0111.2013.04.014
[6]	尤本明, 宋洪杰. 盐酸普鲁卡因注射液稳定性考察 . 药学实践与服务, 2011, 29(2): 125-127.
[7]	黄涛阳, 赵树进, 翁燕君, 邓朝晖. Medilox氧化电位水的稳定性及对手和物体表面消毒效果 . 药学实践与服务, 2009, 27(5): 370-372.
[8]	陈富超, 李琴, 李鹏, 方宝霞, 陈琴华, 朱军. 注射用炎琥宁与头孢呋辛钠配伍的稳定性考察 . 药学实践与服务, 2009, 27(2): 132-133,145.
[9]	王燕琼, 张春, 陈敏玲, 张顺国, 李岚, 姜华. 5种临床常用静脉维持药物再配制后的稳定性 . 药学实践与服务, 2008, (6): 420-421,458.
[10]	王淑君, 石丽, 沈晓芬. 美洛西林钠在木糖醇输液中的配伍稳定性考察 . 药学实践与服务, 2007, (1): 22-24.
[11]	张利斌, 张晓庆, 刘明忠. 注射用氨苄西林钠／氯唑西林钠与不同溶媒配伍稳定性的研究 . 药学实践与服务, 2006, (2): 86-89.
[12]	王彬, 李捷伟, 张国庆. 头孢噻肟钠在0.9%氯化钠注射液中的稳定性 . 药学实践与服务, 2001, (6): 334-336.
[13]	马萍, 辛艳茹, 杨京燕, 苏德森. 离心分光光度法测定乳剂的稳定性 . 药学实践与服务, 2001, (1): 23-23.
[14]	封大慧, 舒薇. 普鲁卡因庆大霉素合剂的稳定性观察 . 药学实践与服务, 1999, (3): 153-154.
[15]	陈文诚. 复方氧氟沙星鼻喷剂的稳定性实验 . 药学实践与服务, 1998, (2): 95-96.
[16]	张鉴, 候宁, 梁烟生. 替硝唑葡萄糖注射液与头孢唑啉钠配伍稳定性观察 . 药学实践与服务, 1998, (1): 44-46.
[17]	李建华, 郭冬英. 盐酸丁卡因注射液稳定性实验 . 药学实践与服务, 1996, (6): 342-343.
[18]	郭涛, 迟卫国, 牟平, 丁立新. 心舒口服液的稳定性考察 . 药学实践与服务, 1996, (6): 337-338.
[19]	尹玉琴, 冯敏, 李莉. 舒巴坦钠在5种大输液中的稳定性考察 . 药学实践与服务, 1996, (5): 286-288.
[20]	郑慰. 盐酸环丙沙星滴眼液稳定性的研究 . 药学实践与服务, 1994, (4): 12-13.

点击查看大图

计量

文章访问数: 2377
HTML全文浏览量: 228
PDF下载量: 710
被引次数: 0

孟鲁司特钠水溶液的胶束性质研究

doi: 10.3969/j.issn.1006-0111.2017.01.009

1. 解放军411医院药学科, 上海 200434;江西中医药大学药学院, 江西南昌 330004

2. 解放军411医院药学科, 上海 200434

收稿日期: 2016-07-30
修回日期: 2016-11-13

关键词:

孟鲁司特钠 /

表面活性 /

临界胶束浓度 /

吸光度 /

透光率 /

稳定性

摘要: 目的研究具有表面活性的药物孟鲁司特钠的水溶液性质，为其开发成胶束及其相关制剂提供实验依据。方法用电导法测定孟鲁司特钠的临界胶束浓度（critical micelle concentration， CMC）并考察温度对CMC的影响；用紫外-可见光分光光度法测定不同浓度孟鲁司特钠水溶液的透光率，并考察加入不同浓度氯化钠对吸光度和透光率的影响；高速离心法考察孟鲁司特钠水溶液形成胶束后的稳定性。结果孟鲁司特钠在25℃、30℃、35℃的CMC分别为0.75、0.82、0.90 mmol/L；氯化钠对孟鲁司特钠水溶液吸光度和透光率的影响不仅与氯化钠的浓度有关，还与孟鲁司特钠溶液的自身浓度有关；当孟鲁司特钠水溶液浓度>7.5 mmol/L时可得到澄清溶液且高速离心无沉淀。结论孟鲁司特钠为具有表面活性作用的药物，其水溶液的胶束性质易受温度和电解质的影响，可利用此性质将其开发为胶束或混合胶束制剂。

English Abstract

Study on the micelle properties of montelukast sodium in aqueous solution

1. Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China;College of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China

2. Department of Pharmacy, No. 411 Hospital of PLA, Shanghai 200434, China

Received Date: 2016-07-30
Rev Recd Date: 2016-11-13

Keywords:

Abstract: Objective To study the physicochemical properties of aqueous solution of surface active drug montelukast sodium (MS), which could provide experimental basis for further development of micelle or mixed micelle preparations. Methods Critical micelle concentration (CMC) of MS at different temperatures were determined by conductivity measurements. The absorbance and transmittance of MS aqueous solution were measured by UV at different sodium chloride concentration levels. The micelle stability was evaluated via high speed centrifugal. Results The CMC of MS aqueous solution at 25℃, 30℃, 35℃ were 0.75, 0.82, 0.90 mmol/L. The absorbance and transmittance of MS aqueous solution were affected by the sodium chloride concentration and the concentration of MS itself. It was observed that a clear solution was obtained when MS concentration >7.5 mmol/L and no precipitation was noticed even after high speed centrifugal. Conclusion Montelukast sodium is a surface active drug. Its solubility is related to MS concentration. The solubility is also sensitive to the temperature and the electrolyte concentration. These unique physicochemical properties could be used to develop micelle or mixed micelle pharmaceutical preparations.

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

引用本文:

鄢寒, 黄月英, 沈一唯, 石晓晴, 卞俊. 孟鲁司特钠水溶液的胶束性质研究[J]. 药学实践与服务, 2017, 35(1): 36-38,66. doi: 10.3969/j.issn.1006-0111.2017.01.009

Citation: