右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响

俞卉; 杨宏; 万方辉; 韩雪敏; 王道灵; 赵晓红

doi:10.3969/j.issn.1006-0111.2016.05.008

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右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响

俞卉, 杨宏, 万方辉, 韩雪敏, 王道灵, 赵晓红

文章导航 > 药学实践与服务 > 2016 > 34(5): 412-415

俞卉, 杨宏, 万方辉, 韩雪敏, 王道灵, 赵晓红. 右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响[J]. 药学实践与服务, 2016, 34(5): 412-415. doi: 10.3969/j.issn.1006-0111.2016.05.008

引用本文:

YU Hui, YANG Hong, WAN Fanghui, HAN Xuemin, WANG Daoling, ZHAO Xiaohong. Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 412-415. doi: 10.3969/j.issn.1006-0111.2016.05.008

Citation:

YU Hui, YANG Hong, WAN Fanghui, HAN Xuemin, WANG Daoling, ZHAO Xiaohong. Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 412-415. doi: 10.3969/j.issn.1006-0111.2016.05.008

右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响

doi: 10.3969/j.issn.1006-0111.2016.05.008

1.
安徽省淮北市人民医院麻醉科, 安徽淮北 235000
2.
复旦大学附属浦东医院麻醉科, 上海 201399

Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

1.
Department of Anesthesiology, Huaibei people's Hospital, Huaibei 235000, China
2.
Department of Anesthesiology, Shanghai Pudong Hospital, Shanghai 201399, China

摘要: 目的评价右美托咪啶对左布比卡因超声引导下行锁骨上臂丛神经阻滞时效及术后疼痛的影响。方法选取80例ASA 分级Ⅰ~Ⅱ级拟择期行上肢手术的患者，随机分成两组：对照组（简称C组），局麻药为含1 ml生理盐水的0.5%左布比卡因30 ml；右美托咪啶组（简称D组），局麻药为含100 μg右美托咪啶（1 ml）的0.5%左布比卡因30 ml。麻醉方法均为超声引导下行锁骨上臂丛神经阻滞。观察指标为：麻醉后上肢感觉神经阻滞、运动神经阻滞的起效时间、持续时间；术后第一次应用镇痛药的时间；麻醉后2 h内的血流动力学指标（平均动脉压和心率）。结果锁骨上臂丛神经阻滞后，两组患者在感觉神经阻滞完全起效的时间上无统计学差异；但与C组相比，D组患者的运动神经阻滞完全起效时间明显缩短（P<0.01），感觉和运动神经阻滞的持续时间均显著延长（P<0.001），术后第一次需求镇痛药的时间也明显长于C组（P<0.001）。同样，D组患者的平均动脉压和心率均明显低于C组（P<0.02）。结论右美托咪啶能够明显延长左布比卡因用于锁骨上臂丛神经阻滞的时效和术后镇痛的时间。
- 右美托咪啶 /
- 左布比卡因 /
- 锁骨上臂丛阻滞
Abstract: Objective To evaluate effects of dexmedetomidine on onset, duration of supraclavicular brachial plexus block induced by levobupivacaine and postoperative analgesia with ultrasound guide. Methods Eighty patients undergoing elective surgeries of distal arm and forearm with class Ⅰ~Ⅱ ASA were enrolled, and the patients were randomly divided into two groups, one was control group (group C) patients with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 1 ml normal saline, the other was dexmedetomidine group patients (group D) with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 100 μg dexmedetomidine. The supraclavicular brachial plexus block was guided with ultrasound. Observation indicators include: sensory and motor onset blocks, duration of sensory and motor blocks, time to first rescue analgesia and hemodynamic parameters. Results The differences of sensory block onset between group C and D were not significant. Compared to group C, motor block onset of group D was significantly shorter (P<0.01), sensory block duration and motor block duration were longer (P<0.001), time to first rescue analgesia after the surgeries was longer (P<0.001). Mean arterial pressure and mean heart rate of group D were significantly lower than those of group C, respectively (P<0.02). Conclusions Dexmedetomidine can significantly prolong the duration of block and postoperative analgesia of supraclavicular brachial plexus block induced by levobupivacaine.
- dexmedetomidine /
- levobupivacaine /
- supraclavicular brachial block

[1]	Kanazi GE, Aouad MT, Jabbour-Khoury SI, et al. Effect of low-dose dexmedetomidine or clonidine on the characteristics of bupivacaine spinal block[J]. Acta Anaesthesiol Scand, 2006,50:222-227.
[2]	Saadawy I, Boker A, Elshahawy MA, et al. Effect of dexmedetomidine on the characteristics of bupivacaine in a caudal block in pediatrics[J]. Acta Anaesthesiol Scand,2009,53:251-256.
[3]	Saumya B, Ratan K, Gauri M, et al. Dexmedetomidine an adjuvant to levobupivacaine in supraclavicular brachial plexus block: a randomized double blind prospective study[J]. Ethiop J Health Sci,2014,24(3):203-208.
[4]	Brummett C, Padda A, Amodeo F, et al. Perineural dexmedetomidine added to ropivacine causes a dose dependent increase in the duration of thermal antinociception in sciatic nerve block in rat[J]. Anesthesiology, 2009, 111:1111-1119.
[5]	Brummett C, Norat M, Palmisano J, et al. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat[J]. Anesthesiology, 2008, 109:502-511.
[6]	Alireza M, Asadollah S, Alireza S, et al. Effects of dexmedetomidine Vs ketorolac as local anesthetic adjuvants on the onset and duration of infraclavicular brachial plexus block[J]. Anesth Pain Med, 2014, 4(3): e17620.
[7]	Ammar AS, Mahmoud KM. Ultrasound-guided single injection infraclavicular brachial plexus block using bupivacaine alone or combined with dexmedetomidine for pain control in upper limb surgery: A prospective randomized controlled trial[J]. Saudi J Anaesth, 2012, 6(2):109-114.
[8]	朱新杰,马瑞,胡芳宝,等. 右美托咪啶对超声引导下罗哌卡因臂丛神经阻滞效果的影响[J].实用疼痛学杂志,2011,7(2):102-105.
[9]	周俊,王汉兵,林文静,等. 右美托咪啶对上肢手术患者罗哌卡因臂丛神经阻滞效果及上肢缺血再灌注损伤的影响[J]. 中华麻醉学杂志, 2011,31(1):84-87.
[10]	李红,程艳欣,陈永学,等. 右美托咪啶对罗哌卡因臂丛神经阻滞半数有效浓度的影响[J]. 河北医科大学学报,2012,33(8):919-922.

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右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响

doi: 10.3969/j.issn.1006-0111.2016.05.008

1. 安徽省淮北市人民医院麻醉科, 安徽淮北 235000

2. 复旦大学附属浦东医院麻醉科, 上海 201399

收稿日期: 2015-09-13
修回日期: 2016-04-16

关键词:

右美托咪啶 /

左布比卡因 /

锁骨上臂丛阻滞

摘要: 目的评价右美托咪啶对左布比卡因超声引导下行锁骨上臂丛神经阻滞时效及术后疼痛的影响。方法选取80例ASA 分级Ⅰ~Ⅱ级拟择期行上肢手术的患者，随机分成两组：对照组（简称C组），局麻药为含1 ml生理盐水的0.5%左布比卡因30 ml；右美托咪啶组（简称D组），局麻药为含100 μg右美托咪啶（1 ml）的0.5%左布比卡因30 ml。麻醉方法均为超声引导下行锁骨上臂丛神经阻滞。观察指标为：麻醉后上肢感觉神经阻滞、运动神经阻滞的起效时间、持续时间；术后第一次应用镇痛药的时间；麻醉后2 h内的血流动力学指标（平均动脉压和心率）。结果锁骨上臂丛神经阻滞后，两组患者在感觉神经阻滞完全起效的时间上无统计学差异；但与C组相比，D组患者的运动神经阻滞完全起效时间明显缩短（P<0.01），感觉和运动神经阻滞的持续时间均显著延长（P<0.001），术后第一次需求镇痛药的时间也明显长于C组（P<0.001）。同样，D组患者的平均动脉压和心率均明显低于C组（P<0.02）。结论右美托咪啶能够明显延长左布比卡因用于锁骨上臂丛神经阻滞的时效和术后镇痛的时间。

English Abstract

Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

1. Department of Anesthesiology, Huaibei people's Hospital, Huaibei 235000, China

2. Department of Anesthesiology, Shanghai Pudong Hospital, Shanghai 201399, China

Received Date: 2015-09-13
Rev Recd Date: 2016-04-16

Keywords:

Abstract: Objective To evaluate effects of dexmedetomidine on onset, duration of supraclavicular brachial plexus block induced by levobupivacaine and postoperative analgesia with ultrasound guide. Methods Eighty patients undergoing elective surgeries of distal arm and forearm with class Ⅰ~Ⅱ ASA were enrolled, and the patients were randomly divided into two groups, one was control group (group C) patients with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 1 ml normal saline, the other was dexmedetomidine group patients (group D) with supraclavicular brachial plexus block by 30 ml of 5% levobupivacaine contained 100 μg dexmedetomidine. The supraclavicular brachial plexus block was guided with ultrasound. Observation indicators include: sensory and motor onset blocks, duration of sensory and motor blocks, time to first rescue analgesia and hemodynamic parameters. Results The differences of sensory block onset between group C and D were not significant. Compared to group C, motor block onset of group D was significantly shorter (P<0.01), sensory block duration and motor block duration were longer (P<0.001), time to first rescue analgesia after the surgeries was longer (P<0.001). Mean arterial pressure and mean heart rate of group D were significantly lower than those of group C, respectively (P<0.02). Conclusions Dexmedetomidine can significantly prolong the duration of block and postoperative analgesia of supraclavicular brachial plexus block induced by levobupivacaine.

引用本文:

Citation:

YU Hui, YANG Hong, WAN Fanghui, HAN Xuemin, WANG Daoling, ZHAO Xiaohong. Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(5): 412-415. doi: 10.3969/j.issn.1006-0111.2016.05.008

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右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响

doi: 10.3969/j.issn.1006-0111.2016.05.008

Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

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右美托咪啶对左布比卡因锁骨上臂丛神经阻滞时效的影响

doi: 10.3969/j.issn.1006-0111.2016.05.008

1. 安徽省淮北市人民医院麻醉科, 安徽 淮北 235000 2. 复旦大学附属浦东医院麻醉科, 上海 201399

English Abstract

Effects of dexmedetomidine on onset and duration of supraclavicular brachial plexus block induced by levobupivacaine

1. Department of Anesthesiology, Huaibei people's Hospital, Huaibei 235000, China 2. Department of Anesthesiology, Shanghai Pudong Hospital, Shanghai 201399, China

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目录

1. 安徽省淮北市人民医院麻醉科, 安徽淮北 235000

2. 复旦大学附属浦东医院麻醉科, 上海 201399

1. Department of Anesthesiology, Huaibei people's Hospital, Huaibei 235000, China

2. Department of Anesthesiology, Shanghai Pudong Hospital, Shanghai 201399, China