Keywords: 
• non-small cell lung cancer (NSCLC) /
• marine /
• tumor marker /
• apoptosis /
• signal pathway

Abstract: Objective To study the effect of preoperative compound matrine injection combined with chemotherapy on serum index apoptotic molecules and signaling molecules expression in tumor tissues of lung cancer patients. Methods Patients with diagnosed lung cancer and planed for surgery in our hospital were selected and divided into combined marine with chemotherapy group and chemotherapy group. Then lung cancer marker molecule contents in serum and mRNA contents of apoptosis regulatory molecules, signaling molecules in tumor tissue were assayed. Results 1Serum lung cancer marker molecules:compared with chemotherapy group, lung cancer marker molecules in serum of combined therapy group SCC, Cyfra21-1, VEGF, TGF-β1, TSGF contents in serum were lower; 2mRNA contents of apoptosis regulation molecules in tumor tissues:compared with chemotherapy group, apoptosis regulation molecules mRNA contents of Caspase-3/7, Fas/FasL, Bim in tumor tissues of combined therapy group were higher, mRNA content of Pim-1 was lower; 3mRNA contents of signal molecules in tumor tissues:compared with signal molecules in tumor tissues of chemotherapy group, mRNA contents of Wnt1, β-catenin, Wnt5a, NFAT, JAK2 and STAT3 in tumor tissues of combined treatment group were lower. Conclusion Preoperative compound matrine injection combined with chemotherapy can be more effective in killing lung cancer cells, reducing serum marker levels, inducing cancer cell apoptosis, inhibiting signaling function; it's an ideal pre-surgery chemotherapy method for patients with non-small cell lung cancer.