1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

秦又发, 张庆, 刘莉

文章导航 > 药学实践与服务 > 2016 > 34(2): 181-183

秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

引用本文:

秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

Citation:

QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

doi: 10.3969/j.issn.1006-0111.2016.02.022

1.
东莞市第三人民医院药学部, 广东东莞 523326
2.
南方医科大学附属南方医院药学部, 广州 510515
3.
湖北医药学院附属随州医院药学部, 湖北随州 441300

Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature

1.
Department of Pharmacy, Third people's Hospital of Dongguan, Dongguan 523326, China
2.
Department of Pharmacy, Nanfang Hospital Affiliated to Southern Medical University, Guangzhou 510515, China
3.
Department of Pharmacy, Suizhou Hospital of Hubei Medicine College, Suizhou 441300, China

摘要: 目的探讨临床药师参与有氟康唑暴露史念珠菌血症患者治疗的对策及效果,为临床有效控制此类感染提供参考。方法在伏立康唑治疗该病患者效果不佳的情况下,临床药师建议采用米卡芬净抗念珠菌治疗。结果患者的念珠菌感染得到有效控制。结论米卡芬净能有效治疗近期(<30 d)有氟康唑暴露史的念珠菌血行感染。临床药师参与临床治疗实践,协助制订个体化治疗方案,有利于提高临床药物治疗水平。
- 米卡芬净 /
- 氟康唑暴露 /
- 念珠菌血症 /
- 棘白菌素类
Abstract: Objective To investigate countermeasures and effects of clinical pharmacists participating in the treatment for fluconazole-exposure candidemia, and to provide reference for infectious control in the clinic. Methods Clinical pharmacists used their professional knowledge and suggested utilizing micafungin to treat candidemia, when voriconazole was ineffective in a patient with candidemia and fluconazole exposure history. Results The patient's candida bloodstream infection was finally controlled. Clinical pharmacists were highly complimented from the doctors, nurses and patients. Conclusion Micafungin is effective in treatment of candidemia with a recent(<30 days) fluconazole exposure history. The participation of clinical pharmacists is helpful to develop individual medicinal therapy in clinical treatment and can improve therapeutic effects.
- micafungin /
- fluconazole-exposure /
- candidemia /
- echinocandins

[1]	Pfaller MA, Diekema DJ.Epidemiology of invasive candidiasis:a persistent public health problem[J].Clin Microbiol Rev, 2007, 20(1):133-163.
[2]	Anunnatsiri S, Chetchotisakd P, Mootsikapun P.Fungemia in non-HIV-infected patients:a five-year review.[J].Int J Infect Dis, 2009, 13(1):90-96.
[3]	Playford EG, Lipman J, Sorrell TC.Management of invasive candidiasis in the intensive care unit.[J].Drugs, 2010, 70(7):823-839.
[4]	Pappas PG, Kauffman CA, Andes D,et al.Clinical practice guidelines for the management of candidiasis:2009 update by the Infectious Diseases Society of America.[J].Clin Infect Dis, 2009, 48(5):503-535.
[5]	Ostrosky-Zeichner L, Pappas PG.Invasive candidiasis in the intensive care unit[J].Crit Care Med, 2006, 34(3):857-863.
[6]	Sanford JP. 热病:桑福德抗微生物治疗指南[M].北京:中国协和医科大学出版社,2011:73.
[7]	Prasad PA, Fisher BT, Coffin SE,et al.Pediatric risk factors for candidemia secondary to and species[J].J Pediatric Infect Dis Soc, 2013, 2(3):263-266.
[8]	Shah DN, Yau R, Lasco TM,et al.Impact of prior inappropriate fluconazole dosing on isolation of fluconazole-nonsusceptible Candida species in hospitalized patients with candidemia[J].Antimicrob Agents Chemother, 2012, 56(6):3239-3243.
[9]	Borst A, Raimer MT, Warnock DW,et al.Rapid acquisition of stable azole resistance by candida glabrata isolates obtained before the clinical introduction of fluconazole[J].Antimicrob Agents Chemother, 2005, 49(2):783-787.
[10]	Lortholary O, Desnos-Ollivier M, Sitbon K,et al.Recent exposure to caspofungin or fluconazole influences the epidemiology of candidemia:a prospective multicenter study involving 2,441 patients[J].Antimicrob Agents Chemother, 2011, 55(2):532-538.
[11]	Magill SS, Shields C, Sears CL,et al.Triazole cross-resistance among Candida spp.:case report, occurrence among bloodstream isolates, and implications for antifungal therapy[J].J Clin Microbiol, 2006, 44(2):529-535.
[12]	Chang TP, Ho MW, Yang YL,et al.Distribution and drug susceptibilities of Candida species causing candidemia from a medical center in central Taiwan[J].J Infect Chemother, 2013.
[13]	Pfaller MA, Diekema DJ, Ostrosky-Zeichner L,et al.Correlation of MIC with outcome for Candida species tested against caspofungin, anidulafungin, and micafungin:analysis and proposal for interpretive MIC breakpoints[J].J Clin Microbiol, 2008, 46(8):2620-2629.
[14]	Messer SA, Diekema DJ, Boyken L,et al.Activities of micafungin against 315 invasive clinical isolates of fluconazole-resistant Candida spp.[J].J Clin Microbiol, 2006, 44(2):324-326.
[15]	胡晶,商洪才,李晶,等.血必净注射液治疗脓毒症的系统评价[J].解放军医学杂志,2010(1):9-12.

[1]	史生辉, 石飞, 雷琼, 王亚峰, 吴雪花. 青藏高原肺结核合并念珠菌感染患者的病原菌分布特点及耐药率分析 . 药学实践与服务, 2024, 42(): 1-4. doi: 10.12206/j.issn.2097-2024.202304014
[2]	万立志, 王境焓, 吴春蓉, 李玲. 基于代谢组学技术的烟酰胺协同两性霉素B抑制白念珠菌的作用机制研究 . 药学实践与服务, 2024, 42(): 1-6. doi: 10.12206/j.issn.2097-2024.202307034
[3]	邓忠宇, 郭士槿, 郭熠凡, 冯峻程, 吕权真, 邱丽娟. 药物联用抑制白念珠菌生长的研究进展 . 药学实践与服务, 2023, 41(6): 352-357. doi: 10.12206/j.issn.2097-2024.202112019
[4]	徐怡澜, 阎澜. 光滑念珠菌耐药机制的研究进展 . 药学实践与服务, 2023, 41(7): 393-395, 432. doi: 10.12206/j.issn.2097-2024.202202050
[5]	王欣荣, 鲁仁义, 王彦. SDH2基因在白念珠菌环境适应性中的作用 . 药学实践与服务, 2022, 40(4): 309-313. doi: 10.12206/j.issn.1006-0111.202201096
[6]	孔飞飞, 郑巍, 郭良君, 金永生. 马尾松叶低极性部位的GC-MS分析及协同氟康唑抗耐药白念珠菌活性研究 . 药学实践与服务, 2021, 39(5): 399-402, 441. doi: 10.12206/j.issn.1006-0111.202101011
[7]	范加腾, 陆峰, 许激扬. 基于D-SERS法表征两性霉素B对白色念珠菌抑制作用的研究 . 药学实践与服务, 2019, 37(2): 156-161,169. doi: 10.3969/j.issn.1006-0111.2019.02.011
[8]	王科兵, 陈志红, 郭步, 陆国忠. 表面增强拉曼光谱法快速鉴别失活白色念珠菌 . 药学实践与服务, 2017, 35(5): 422-426. doi: 10.3969/j.issn.1006-0111.2017.05.009
[9]	张金宇, 王丽红, 秦玉璘, 张璐璐, 姜远英, 曹永兵. 转录因子Cup2对白念珠菌铜离子代谢、氧化应激调控作用的初步研究 . 药学实践与服务, 2017, 35(3): 224-228. doi: 10.3969/j.issn.1006-0111.2017.03.008
[10]	毕爽, 胡丹丹, 姜远英, 王彦. 白念珠菌的高适应性与代谢 . 药学实践与服务, 2016, 34(2): 116-118,173. doi: 10.3969/j.issn.1006-0111.2016.02.006
[11]	赵晶, 李冉, 代黎, 蔡瞻, 张大志, 姜远英. 协同氟康唑抗耐药白念珠菌化合物的设计合成及活性研究 . 药学实践与服务, 2016, 34(2): 129-134. doi: 10.3969/j.issn.1006-0111.2016.02.009
[12]	杨宇, 王慧, 曹颖瑛, 朱臻宇. 基于气相色谱-质谱技术对用咪康唑处理的白念珠菌的代谢组学研究 . 药学实践与服务, 2015, 33(3): 209-212. doi: 10.3969/j.issn.1006-0111.2015.03.005
[13]	梁华军, 阎澜, 曹永兵, 姜远英, 颜天华. 白色念珠菌TOR信号转导通路研究现状 . 药学实践与服务, 2014, 32(4): 246-249,287. doi: 10.3969/j.issn.1006-0111.2014.04.002
[14]	纪松岗, 杨宇, 李康, 吴海棠, 朱臻宇. 柱前衍生化-高效液相色谱法测定白念珠菌中多胺的含量 . 药学实践与服务, 2013, 31(6): 412-414,453. doi: 10.3969/j.issn.1006-0111.2013.06.04
[15]	王添琦, 李祥, 李玲, 吴海棠, 徐立. 气质联用法定量分析白念珠菌中甾醇含量 . 药学实践与服务, 2013, 31(4): 277-279,320. doi: 10.3969/j.issn.1006-0111.2013.04.010
[16]	董玲玲, 曹颖瑛, 柴逸峰. 液质联用方法测定白色念珠菌中海藻糖的含量 . 药学实践与服务, 2010, 28(3): 186-188.
[17]	徐进, 周恩旭, 曹颖瑛. 白色念珠菌疫苗的研究进展 . 药学实践与服务, 2008, (1): 5-6.
[18]	张尚文, 张紫洞. 抗真菌新药——氟康唑 . 药学实践与服务, 1991, (3): 9-10.
[19]	虞瑞尧. 三种唑类抗真菌药——酮康唑、伊康唑和氟康唑 . 药学实践与服务, 1991, (2): 10-13.
[20]	TohnE.Connons. 头孢菌素类抗生素在外科预防中的作用 . 药学实践与服务, 1989, (1): 16-20.

WeChat

点击查看大图

计量

文章访问数: 2927
HTML全文浏览量: 293
PDF下载量: 10
被引次数: 0

1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习

doi: 10.3969/j.issn.1006-0111.2016.02.022

1. 东莞市第三人民医院药学部, 广东东莞 523326

2. 南方医科大学附属南方医院药学部, 广州 510515

3. 湖北医药学院附属随州医院药学部, 湖北随州 441300

收稿日期: 2014-08-02
修回日期: 2015-08-28

关键词:

氟康唑暴露 /

念珠菌血症 /

棘白菌素类

摘要: 目的探讨临床药师参与有氟康唑暴露史念珠菌血症患者治疗的对策及效果,为临床有效控制此类感染提供参考。方法在伏立康唑治疗该病患者效果不佳的情况下,临床药师建议采用米卡芬净抗念珠菌治疗。结果患者的念珠菌感染得到有效控制。结论米卡芬净能有效治疗近期(<30 d)有氟康唑暴露史的念珠菌血行感染。临床药师参与临床治疗实践,协助制订个体化治疗方案,有利于提高临床药物治疗水平。

English Abstract

秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

引用本文:

秦又发, 张庆, 刘莉. 1例米卡芬净治疗有氟康唑暴露史念珠菌血症的病例分析及相关文献复习[J]. 药学实践与服务, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

Citation:

QIN Youfa, ZHANG Qing, LIU Li. Clinical analysis of 1 case of micafungin treatment: fluconazole-exposed candidemia and review of related literature[J]. Journal of Pharmaceutical Practice and Service, 2016, 34(2): 181-183. doi: 10.3969/j.issn.1006-0111.2016.02.022

全文HTML

参考文献 (15)

/

下载: 全尺寸图片幻灯片

分享

用微信扫码二维码

分享至好友和朋友圈

返回

版权所有：《药学实践与服务》编辑委员会

主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

网站备案号沪ICP备05003363号-1

本系统由北京仁和汇智信息技术有限公司开发