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核苷酸适体在靶向给药系统中的应用进展

熊叶,  台宗光,  李强

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文章导航 > 药学实践与服务  > 2015 >  33(6): 490-493,532
熊叶, 台宗光, 李强. 核苷酸适体在靶向给药系统中的应用进展[J]. 药学实践与服务, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
引用本文: 熊叶, 台宗光, 李强. 核苷酸适体在靶向给药系统中的应用进展[J]. 药学实践与服务, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
shu
XIONG Ye, TAI ZongGuang, Li Qiang. Application progress of nucleic acid aptamers in targeted drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
Citation: XIONG Ye, TAI ZongGuang, Li Qiang. Application progress of nucleic acid aptamers in targeted drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
shu

核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003
  • 1.

    第二军医大学附属长海医院, 上海 200433

  • 2.

    第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东 青岛 266102

基金项目: 国家自然科学基金项目(No.81170060)

Application progress of nucleic acid aptamers in targeted drug delivery system

  • 1.

    Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

  • 2.

    Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China;Hospital of CPLA No.92330 Troop, Qingdao 266102, China

  • 摘要: 适体,即体外合成筛选得到的能特异性地与靶分子结合的一段寡核苷酸序列。由于其独特的性质,在靶向给药系统中有着广阔的应用前景,目前已成为靶向给药研究领域的热点。综述了适体在靶向给药系统中的优势及其应用进展,并对其应用前景和面临的问题进行分析。
    Abstract: Aptamers are single stranded oligonucleotides that have high affinity and specificity towards a wide range of target molecules. Owing to the indispensable advantages, aptamers have wildly prospects and have become a research hotspot in targeted drug delivery system (TDDS). In this article, application advantage and progress of aptamers in TDDS were briefly reviewed, the problems and prospects were also discussed.
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  • 收稿日期:  2013-11-04
  • 修回日期:  2014-12-24

核苷酸适体在靶向给药系统中的应用进展

doi: 10.3969/j.issn.1006-0111.2015.06.003
  • 1. 第二军医大学附属长海医院, 上海 200433
  • 2. 第二军医大学附属长海医院, 上海 200433;解放军92330部队医院, 山东 青岛 266102
    • 基金项目:  国家自然科学基金项目(No.81170060)
  • 收稿日期: 2013-11-04
  • 修回日期: 2014-12-24

摘要: 适体,即体外合成筛选得到的能特异性地与靶分子结合的一段寡核苷酸序列。由于其独特的性质,在靶向给药系统中有着广阔的应用前景,目前已成为靶向给药研究领域的热点。综述了适体在靶向给药系统中的优势及其应用进展,并对其应用前景和面临的问题进行分析。

English Abstract

熊叶, 台宗光, 李强. 核苷酸适体在靶向给药系统中的应用进展[J]. 药学实践与服务, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
引用本文: 熊叶, 台宗光, 李强. 核苷酸适体在靶向给药系统中的应用进展[J]. 药学实践与服务, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
shu
XIONG Ye, TAI ZongGuang, Li Qiang. Application progress of nucleic acid aptamers in targeted drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
Citation: XIONG Ye, TAI ZongGuang, Li Qiang. Application progress of nucleic acid aptamers in targeted drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(6): 490-493,532. doi: 10.3969/j.issn.1006-0111.2015.06.003
shu

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