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药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

张中湖,  李皓,  李军,  陆峰

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文章导航 > 药学实践与服务  > 2015 >  33(5): 441-444
张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
引用本文: 张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
shu
ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
Citation: ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
shu

药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

doi: 10.3969/j.issn.1006-0111.2015.05.016
  • 1.

    山东省食品药品检验研究院, 山东 济南 250101

  • 2.

    第二军医大学药学院, 上海 200433

基金项目: 科技部重大科学仪器设备开发专项(2012YQ180132)

The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient

  • 1.

    Shandong Institute for Food and Drug Control, Jinan 250101, China

  • 2.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 目的 建立常用药物辅料(甘油)中有毒掺杂物(二甘醇)的快速检测方法。 方法 利用拉曼/近红外光谱法结合移动窗口相关系数法评价有毒掺杂物的检测灵敏度。 结果 拉曼光谱下获得的检测灵敏度优于近红外光谱,同时移动窗口法可进一步提高检测灵敏度。 结论 拉曼光谱法有望成为现场快速检测药物辅料中掺杂有毒物质的有效方法。
    Abstract: Objective To develop a rapid method for the detection of toxic adulterant (diethylene glycol) in pharmaceutical excipient (glycerol). Method The detection sensitivity of Raman/ near infrared (NIR) spectroscopy combined with moving window correlation coefficient (MWCC) method was evaluated. Results The detection sensitivity of Raman spectroscopy was superior to that of NIR spectroscopy and with the assistance of MWCC method; the sensitivity had been further improved. Conclusion Raman spectroscopy has the potential to become the effective method in the on-site detection of toxic adulterant in pharmaceutical excipient.
  • [1] Khalique MA,Michael PM,Jean N,et al.Fourier transform infrared and near-infrared spectroscopic methods for the detection of toxic diethylene glycol (DEG) contaminant in glycerin based cough syrup[J]. Spectrosc, 2010, 24: 601-608.
    [2] Lin BL, Zhao ZX, Chong YT, et al. Venous diethylene glycol poisoning in patients with preexisting severe liver disease in China[J]. World J Gastroenterol, 2008,14: 3236-3241.
    [3] Yua H, Cornettb C, Larsenb J, et al. Reaction between drug substances and pharmaceutical excipients: formation of esters between cetirizine and polyols[J]. J Pharm Biomed Anal, 2010, 53: 745-750.
    [4] Liltorp K, Larsenb TG, Willumsenb B, et al. Solid state compatibility studies with tablet excipients using non thermal methods[J]. J Pharm Biomed Anal, 2011, 55: 424-428.
    [5] Ali EMA, Edwards HGM, Scowen IJ. In-situ detection of single particles of explosive on clothing with confocal Raman microscopy[J]. Talanta, 2009, 78: 1201-1203.
    [6] Lyndgaard LB, van den BF, de Juan A. Quantification of paracetamol through tablet blister packages by Raman spectroscopy and multivariate curve resolution-alternating least squares[J]. Chemom Intell Lab Syst, 2013,125: 58-66.
    [7] Rodriguez JD, Westenberger BJ, Buhse LF, et al. Quantitative evaluation of the sensitivity of library-based Raman spectral correlation methods[J]. Anal Chem, 2011, 83 : 4061-4067.
    [8] Kim J, Hwang J, Chung H. Comparison of near-infrared and Raman spectroscopy for on-line monitoring of etchant solutions directly through a Teflon tube[J]. Anal Chim Acta, 2008, 629: 119-127.
    [9] Chu XL, Xu YP, Tian SB, et al. Rapid identification and assay of crude oils based on moving-window correlation coefficient and near infrared spectral library[J]. Chemom Intell Lab Syst, 2011, 107: 44-49.
    [10] Du YP, Liang YZ, Jiang JH, et al. Spectral regions selection to improve prediction ability of PLS models by changeable size moving window partial least squares and searching combination moving window partial least squares[J]. Anal Chim Acta, 2004, 501: 183-191.
    [11] Ruzicka CMG, Arzhantsev S, Pelster LN, et al. Multivariate calibration and instrument standardization for the rapid detection of diethylene glycol in glycerin by Raman spectroscopy[J]. Appl Spectrosc, 2011, 65 : 334-341.
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  • 收稿日期:  2015-05-29
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药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价

doi: 10.3969/j.issn.1006-0111.2015.05.016
  • 1. 山东省食品药品检验研究院, 山东 济南 250101
  • 2. 第二军医大学药学院, 上海 200433
    • 基金项目:  科技部重大科学仪器设备开发专项(2012YQ180132)
  • 收稿日期: 2015-05-29
  • 修回日期: 2015-07-26

摘要: 目的 建立常用药物辅料(甘油)中有毒掺杂物(二甘醇)的快速检测方法。 方法 利用拉曼/近红外光谱法结合移动窗口相关系数法评价有毒掺杂物的检测灵敏度。 结果 拉曼光谱下获得的检测灵敏度优于近红外光谱,同时移动窗口法可进一步提高检测灵敏度。 结论 拉曼光谱法有望成为现场快速检测药物辅料中掺杂有毒物质的有效方法。

English Abstract

张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
引用本文: 张中湖, 李皓, 李军, 陆峰. 药物辅料中有毒掺杂物的拉曼/近红外光谱法检测灵敏度评价[J]. 药学实践与服务, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
shu
ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
Citation: ZHANG Zhonghu, LI Hao, LI Jun, LU Feng. The sensitivity evaluation of Raman spectroscopy and near infrared spectroscopy; in toxic adulterant detection of pharmaceutical excipient[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(5): 441-444. doi: 10.3969/j.issn.1006-0111.2015.05.016
shu

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