羧甲基壳聚糖络合碘复合材料的合成和止血活性评价

李冬冬; 吴岳林; 缪震元; 张万年; 华万森; 张火俊

doi:10.3969/j.issn.1006-0111.2015.02.008

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羧甲基壳聚糖络合碘复合材料的合成和止血活性评价

李冬冬, 吴岳林, 缪震元, 张万年, 华万森, 张火俊

文章导航 > 药学实践与服务 > 2015 > 33(2): 125-126,178

李冬冬, 吴岳林, 缪震元, 张万年, 华万森, 张火俊. 羧甲基壳聚糖络合碘复合材料的合成和止血活性评价[J]. 药学实践与服务, 2015, 33(2): 125-126,178. doi: 10.3969/j.issn.1006-0111.2015.02.008

引用本文:

LI Dongdong, WU Yuelin, MIAO Zhenyuan, ZHANG Wannian, HUA Wansen, ZHANG Huojun. Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 125-126,178. doi: 10.3969/j.issn.1006-0111.2015.02.008

Citation:

LI Dongdong, WU Yuelin, MIAO Zhenyuan, ZHANG Wannian, HUA Wansen, ZHANG Huojun. Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(2): 125-126,178. doi: 10.3969/j.issn.1006-0111.2015.02.008

羧甲基壳聚糖络合碘复合材料的合成和止血活性评价

doi: 10.3969/j.issn.1006-0111.2015.02.008

1.
南京理工大学化工学院, 江苏南京 210094;第二军医大学附属长海医院, 上海 200433
2.
南京理工大学化工学院, 江苏南京 210094;第二军医大学药学院, 上海 200433
3.
第二军医大学药学院, 上海 200433
4.
南京理工大学化工学院, 江苏南京 210094
5.
第二军医大学附属长海医院, 上海 200433

基金项目: 第二军医大学医学专项资助(2011JS14)

Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan

1.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China
2.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China
3.
School of Pharmacy, Second Military Medical University, Shanghai 200433, China
4.
School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China
5.
Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

摘要: 目的研究羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮络合碘材料的止血活性。方法在偶氮二异丁腈引发下,以丙烯酸钠、N-乙烯基吡咯烷酮、羧甲基壳聚糖和N,N'-亚甲基双丙烯酰胺为原料制备羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮。然后与碘络合生成羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮络合碘材料,同时进行止血活性测试。结果合成的材料具有很强的吸水性能,平均吸水倍率为103 g/g,并且具有很好的耳静脉和股静脉止血效果。结论合成材料的止血效果优于止血海绵和Quikclot。
- 羧甲基壳聚糖 /
- 络合碘 /
- 止血活性
Abstract: Objective To study the hemostasis activity of iodine complex with carboxymethyl chitosan. Methods The polymers were prepared with azodiisobutyronitrile as the initiating agent and sodium acrylate, N-vinylpyrrolidone, carboxymethyl chitosan and N,N'-methylene diacrylamide as the raw materials. It was then complexed with iodine to generate iodine complex with carboxymethyl chitosan, and the hemostasis activity was tested at the same time. Results The polymers could absorb water with the value of 103g/g and showed potent hemostasis activity for auricular veins and femoral veins. Conclusion The results showed that hemostatic effect of polymers was better than that of hemostatic sponge and Quikclot.
- carboxymethyl chitosan /
- iodine complex /
- hemostasis activity

[1]	Uitte de Willige S, Miedzak M, Carter AM, et al. Oteolytic and genetic variation of the alpha-2-antiplasmin C-terminus in myocardial infarction[J].Blood,2011,117(24): 6694-6701.
[2]	李钒,田丰,刘长军,等. 急救止血材料的研究进展[J].材料导报A:综述篇,2013,27(2):70-73.
[3]	石凉,汪涛,吴大洋. 壳聚糖止血材料及最新研究进展[J].蚕业科学,2009, 35(4):929-933.
[4]	李保强,黄雁鸣,张宇,等. 壳聚糖复合止血膜的制备及性能评价[J].中国修复重建外科杂志,2010, 24(3):340-343.
[5]	尹刚,候春林,刘万顺,等. 新型壳聚糖止血粉止血作用的实验研究[J].中国修复重建外科杂志,2009,23(11):1347-1349.
[6]	方哲,周玉杰,史冬梅,等. 壳聚糖止血敷料止血装置在经桡动脉冠状动脉介入治疗术后的临床应用[J].临床内科杂志,2013,30(9):624-626.
[7]	陈煜,陆铭,唐弈,等.羧甲基壳聚糖接枝丙烯酸钠/乙烯基吡咯烷酮高吸水性树脂的合成[J].石油化工,2004,33(12):1137-1141.

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羧甲基壳聚糖络合碘复合材料的合成和止血活性评价

doi: 10.3969/j.issn.1006-0111.2015.02.008

1. 南京理工大学化工学院, 江苏南京 210094;第二军医大学附属长海医院, 上海 200433

2. 南京理工大学化工学院, 江苏南京 210094;第二军医大学药学院, 上海 200433

3. 第二军医大学药学院, 上海 200433

4. 南京理工大学化工学院, 江苏南京 210094

5. 第二军医大学附属长海医院, 上海 200433

基金项目: 第二军医大学医学专项资助(2011JS14)

收稿日期: 2014-05-01
修回日期: 2014-08-25

关键词:

羧甲基壳聚糖 /

络合碘 /

止血活性

摘要: 目的研究羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮络合碘材料的止血活性。方法在偶氮二异丁腈引发下,以丙烯酸钠、N-乙烯基吡咯烷酮、羧甲基壳聚糖和N,N'-亚甲基双丙烯酰胺为原料制备羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮。然后与碘络合生成羧甲基壳聚糖接枝聚丙烯酸钠/乙烯基吡咯烷酮络合碘材料,同时进行止血活性测试。结果合成的材料具有很强的吸水性能,平均吸水倍率为103 g/g,并且具有很好的耳静脉和股静脉止血效果。结论合成材料的止血效果优于止血海绵和Quikclot。

English Abstract

Synthesis and hemostasis activity of iodine complex with carboxymethyl chitosan

1. School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

2. School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

3. School of Pharmacy, Second Military Medical University, Shanghai 200433, China

4. School of Chemical Engineering, Nanjing University of Science & Technology, Nanjing 210094, China

5. Changhai Hospital Affiliated to Second Military Medical University, Shanghai 200433, China

Received Date: 2014-05-01
Rev Recd Date: 2014-08-25

Keywords:

Abstract: Objective To study the hemostasis activity of iodine complex with carboxymethyl chitosan. Methods The polymers were prepared with azodiisobutyronitrile as the initiating agent and sodium acrylate, N-vinylpyrrolidone, carboxymethyl chitosan and N,N'-methylene diacrylamide as the raw materials. It was then complexed with iodine to generate iodine complex with carboxymethyl chitosan, and the hemostasis activity was tested at the same time. Results The polymers could absorb water with the value of 103g/g and showed potent hemostasis activity for auricular veins and femoral veins. Conclusion The results showed that hemostatic effect of polymers was better than that of hemostatic sponge and Quikclot.

引用本文: