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应中央军委要求,2022年9月起,《药学实践杂志》将更名为《药学实践与服务》,双月刊,正文96页;2023年1月起,拟出版月刊,正文64页,数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿!

双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

高洪元 吴建勇 倪曙民

高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
引用本文: 高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
Citation: GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003

双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

doi: 10.3969/j.issn.1006-0111.2015.01.003

Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors

  • 摘要: 血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力,采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集,从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展,为相关研究提供参考。
  • [1] Pardridge WM.BBB-Genomics:creating new openings for brain-drug targeting[J].Drug Discov Today,2001,6(8):381-383.
    [2] van Rooy I,Mastrobattista E,Storm G,et al.Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain[J].J Control Release,2011,150(1):30-36.
    [3] Chen H,Qin Y,Zhang Q,et al.Lactoferrin modified doxorubicin-loaded procationic liposomes for the treatment of gliomas[J]. Eur J Pharm Sci,2011,44(1-2):164-173.
    [4] Demeule M,Currie JC,Bertrand Y,et al.Involvement of the low-density lipoprotein receptor-related protein in the transcytosis of the brain delivery vector angiopep-2[J].J Neurochem,2008,106(4):1534-1544.
    [5] Xin H,Jiang X,Gu J,et al.Angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma[J].Biomaterials,2011,32(18):4293-4305.
    [6] Xin H,Sha X,Jiang X,et al.Anti-glioblastoma efficacy and safety of paclitaxel-loading angiopep-conjugated dual targeting PEG-PCL nanoparticles[J].Biomaterials,2012,33(32):8167-8176.
    [7] Xin H,Sha X,Jiang X,et al.The brain targeting mechanism of angiopep-conjugated poly(ethylene glycol)-co-poly(ε-caprolactone) nanoparticles[J].Biomaterials,2012,33(5):1673-1681.
    [8] Huang S,Li J,Han L,et al.Dual targeting effect of angiopep-2-modified,DNA-loaded nanoparticles for glioma[J].Biomaterials,2011,32(28):6832-6838.
    [9] Ren J,Shen S,Wang D,et al.The targeted delivery of anticancer drugs to brain glioma by PEGylated oxidized multi-walled carbon nanotubes modified with angiopep-2[J].Biomaterials,2012,33(11):3324-3333.
    [10] Li J,Zhou L,Ye D,et al.Choline-derivate-modified nanoparticles for brain-targeting gene delivery[J].Adv Mater,2011,23(39):4516-4520.
    [11] Machová E,O'Regan S,Newcombe J,et al.Detection of choline transporter-like 1 protein CTL1 in neuroblastoma x glioma cells and in the CNS,and its role in choline uptake[J].J Neurochem,2009,110(4):1297-1309.
    [12] Li J,Guo Y,Kuang Y,et al.Choline transporter-targeting and co-delivery system for glioma therapy[J].Biomaterials,2013,34(36):9142-9148.
    [13] Li J,Huang S,Shao K,et al.A choline derivate-modified nanoprobe for glioma diagnosis using MRI[J].Sci Rep,2013,3:1623.
    [14] Malcor JD,Payrot N,David M,et al.Chemical optimization of new ligands of the low-density lipoprotein receptor as potential vectors for central nervous system targeting[J].J Med Chem,2012,55(5):2227-2241.
    [15] Zhang B,Sun X,Mei H,et al.LDLR-mediated peptide-22-conjugated nanoparticles for dual-targeting therapy of brain glioma[J].Biomaterials,2013,34(36):9171-9182.
    [16] Zhu L,Wang H,Wang L,et al.High-affinity peptide against MT1-MMP for in vivo tumor imaging[J].J Control Release,2011, 150(3):248-255.
    [17] Gu G,Gao X,Hu Q,et al.The influence of the penetrating peptide iRGD on the effect of paclitaxel-loaded MT1-AF7p-conjugated nanoparticles on glioma cells[J].Biomaterials,2013,34(21):5138-5148.
    [18] Li J,Feng L,Fan L,et al.Targeting the brain with PEG-PLGA nanoparticles modified with phage-displayed peptides[J].Biomaterials,2011,32(21):4943-4950.
    [19] Guo J,Gao X,Su L,et al.Aptamer-functionalized PEG-PLGA nanoparticles for enhanced anti-glioma drug delivery[J].Biomaterials,2011,32(31):8010-8020.
    [20] Gao H,Qian J,Cao S,et al.Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles[J].Biomaterials,2012,33(20):5115-5123.
    [21] Gao JQ,Lv Q,Li LM,et al.Glioma targeting and blood-brain barrier penetration by dual-targeting doxorubincin liposomes[J].Biomaterials,2013,34(22):5628-5639.
    [22] Paleĉek J,Dräger G,Kirschning A.A practical large-scale synthesis of cyclic RGD pentapeptides suitable for further functionalization through‘click’chemistry[J].Synthesis,2011,(4):653-661.
    [23] Zhang P,Hu L,Yin Q,et al.Transferrin-modified c[RGDfK]-paclitaxel loaded hybrid micelle for sequential blood-brain barrier penetration and glioma targeting therapy[J].Mol Pharm,2012,9(6):1590-1598.
    [24] Sugimoto Y,Tsukahara S,Imai Y,et al.Reversal of breast cancer resistance protein-mediated drug resistance by estrogen antagonists and agonists[J].Mol Cancer Ther,2003,2(1):105-112.
    [25] Tian W,Ying X,Du J,et al.Enhanced efficacy of functionalized epirubicin liposomes in treating brain glioma-bearing rats[J].Eur J Pharm Sci,2010,41(2):232-243.
    [26] He H,Li Y,Jia XR,et al.PEGylated Poly(amidoamine) dendrimer-based dual-targeting carrier for treating brain tumors[J].Biomaterials,2011,32(2):478-487.
    [27] Du J,Lu WL,Ying X,et al.Dual-targeting topotecan liposomes modified with tamoxifen and wheat germ agglutinin significantly improve drug transport across the blood-brain barrier and survival of brain tumor-bearing animals[J].Mol Pharm,2009,6(3):905-917.
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  • 收稿日期:  2013-11-12
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双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用

doi: 10.3969/j.issn.1006-0111.2015.01.003

摘要: 血脑屏障的存在严重阻碍了脑肿瘤化疗药物向脑内递送。纳米粒、脂质体、胶束等纳米载体可显著增加药物的穿过血脑屏障转运的能力,采用单一或双功能基制备的双级靶向纳米载体还可进一步增加药物的脑内递送及在脑肿瘤病变部位的浓集,从而显著提高脑肿瘤的诊断和治疗效果。笔者主要介绍双级靶向纳米载体的设计思路、靶向功能基的最新研究进展,为相关研究提供参考。

English Abstract

高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
引用本文: 高洪元, 吴建勇, 倪曙民. 双级靶向纳米载体在脑肿瘤诊断和治疗方面的应用[J]. 药学实践与服务, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
Citation: GAO Hongyuan, WU Jianyong, NI Shumin. Application of dual-targeting nano-carriers in diagnosis and therapy of brain tumors[J]. Journal of Pharmaceutical Practice and Service, 2015, 33(1): 9-12,16. doi: 10.3969/j.issn.1006-0111.2015.01.003
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