留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

卜晓琳,  毕新岭,  徐晓光,  高志祥,  李慧,  顾军

downloadPDF
文章导航 > 药学实践与服务  > 2014 >  32(6): 405-408
卜晓琳, 毕新岭, 徐晓光, 高志祥, 李慧, 顾军. 甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展[J]. 药学实践与服务, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
引用本文: 卜晓琳, 毕新岭, 徐晓光, 高志祥, 李慧, 顾军. 甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展[J]. 药学实践与服务, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
shu
BU Xiaolin, BI Xinling, XU Xiaoguang, GAO Zhixiang, LI Hui, GU Jun. The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
Citation: BU Xiaolin, BI Xinling, XU Xiaoguang, GAO Zhixiang, LI Hui, GU Jun. The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
shu

甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002
  • 1.

    上海市浦东新区公利医院皮肤科, 上海 200135;第二军医大学附属长海医院皮肤科, 上海 200433

  • 2.

    第二军医大学附属长海医院皮肤科, 上海 200433

基金项目: 浦东新区卫生系统优秀青年医学人才培养计划(PWRq2013-02).

The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease

  • 1.

    Department of Dermatology, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China;Department of Dermatology, Changhai Hospital affiliated to Secend Military Medical University, Shanghai 200433, China

  • 2.

    Department of Dermatology, Changhai Hospital affiliated to Secend Military Medical University, Shanghai 200433, China

  • 摘要: 甲状旁腺素(PTH)和甲状旁腺素相关肽(PTHrP)是一类多肽类激素,它们具有相似的基因结构、相同的膜受体,在人体钙、磷代谢过程中起着重要的调节作用。PTH和PTHrP及其受体除表达于肿瘤组织外,在皮肤、毛囊等正常组织也有表达。它们对表皮增殖分化、毛发生长的生理作用等方面,有望成为银屑病等常见皮肤病的治疗新靶点。
    Abstract: Parathyroid hormone/parathyroid hormone-related peptides are polypeptide hormones. They have similar gene structure and same membrane receptor. They play great roles in regulating the calcium and phosphorus metabolism in vivo. PTH/PTHrP and their receptors are expressed in tissues of tumor,skin, hair follicle and other normal tissues. Because of their physiological action on the proliferation and differentiation of epidermis and hair growth,they may be a potential therapeutic target for some skin diseases including psoriasis.
  • [1] Oquendo M, Abramovits W, Morrell P.Topical vitamin D analogs available to treat psoriasis[J]. Skin Med, 2012,10(6):356-360.
    [2] Shah KN.Diagnosis and treatment of pediatric psoriasis: current and future[J]. Am J Clin Dermatol,2013,14(3):195-213.
    [3] Holick MF. Clinical efficacy of 1,25-dihydroxyvitamin D3 and its analogues in the treatment of psoriasis[J]. Retinoids,1998,14: 12-17.
    [4] Cupp ME, Nayak SK, Adem AS, et al.Parathyroid hormone (PTH) and PTH-related peptide domains contributing to activation of different PTH receptor-mediated signaling pathways[J]. J Pharmacol Exp Ther,2013,345(3):404-418.
    [5] Whitfield JF, Isaacs RJ, Chakravarthy B, et al.Stimulation of protein kinase C activity in cells expressing human parathyroid hormone receptors by C-and N-terminally truncated fragments of parathyroid hormone 1-34[J]. J Bone Miner Res, 2001,16(3):441-447.
    [6] Strewler GJ,Nissenson RA.Hypercalcemia in malignancy[J]. West J Med,1990,153(6):635-640.
    [7] Wysolmerski JJ, Broadus AE.Hypercalcemia of malignancy: the central role of parathyroid hormone-related protein[J]. Annu Rev Med, 1994,45:189-200.
    [8] Strewler GJ. The parathyroid hormone-related protein[J]. Endocrinol Metab Clin North Am, 2000,29(3):629-645.
    [9] Milanesi A, Yu R, Wolin EM.Humoral hypercalcemia of malignancy caused by parathyroid hormone-related peptide-secreting neuroendocrine tumors: report of six cases[J]. Pancreatology, 2013,13(3):324-326.
    [10] Nilubol N, Weisbrod AB, Weinstein LS,et al.Utility of intraoperative parathyroid hormone monitoring in patients with multiple endocrine neoplasia type 1-associated primary hyperparathyroidism undergoing initial parathyroidectomy[J]. World J Surg,2013,37(8):1966-1972.
    [11] Hiremath M, Wysolmerski J.Parathyroid hormone-related protein apecifies the mammary mesenchyme and regulates embryonic mammary sevelopment[J]. J Mamm Gland Biol Neopl,2013,18(2):171-177.
    [12] Jia T, Qureshi AR, Brandenburg V,et al.Determinants of dibroblast growth dactor-23 and parathyroid hormone variability in dialysis patients[J]. Am J Nephrol, 2013,37(5):462-471.
    [13] Metzger M, Houillier P, Gauci C, et al.Relation between circulating levels of 25(OH) vitamin D and parathyroid hormone in chronic kidney disease: quest for a threshold[J].J Clin Endocrinol Metab,2013,98(7):2922-2928.
    [14] Urea P.The PTH/PTHrP receptor: biological implications[J].Nefrologia,2003,23(Suppl 2):12-17.
    [15] Errazahi A, Bouizar Z, Lieberherr M,et al.Functional type I PTH/PTHrP receptor in freshly isolated newborn rat keratinocytes: identification by RT-PCR and immunohistochemistry[J].J Bone Miner Res, 2003,18(4):737-750.
    [16] Calvi LM, Adams GB, Weibrecht KW,et al. Osteoblastic cells regulate the haematopoietic stem cell niche[J].Nature, 2003,425(6960):841-846.
    [17] Weber JM, Adams GB, Guaman ML, et al. Parathyroid treatment improves survival after bone marrow transplantation and increases osteoblastic expression of the Notch ligand Jagged 1[J].J Bone Miner Res,2004,19:S407.
    [18] Aho S.Soluble form of Jagged1: unique product of epithelial keratinocytes and a regulator of keratinocyte differentiation[J].J Cell Biochem, 2004,92(6):1271-1281.
    [19] Holick MF, Nussbaum S, Persons KS. PTH-like humoral hypercalcemia factor (HHF) of malignancy may be an epidermal differentiation factor:synthetic hHHF(1-34) NH2 inhibits proliferation and induces terminal differentiation of cultured human kerationcytes[J].J Bone Miner Res,1988,3:S214.
    [20] Hanafin NM, Chen TC, Heinrich G,et al.Cultured human fibroblasts and not cultured human keratinocytes express a PTH/PTHrP receptor mRNA[J].J Invest Dermatol,1995,105(1):133-137.
    [21] Whitfield JF.Taming psoriatic keratinocytes-PTHs'uses go up another notch[J].J Cell Biochem,2004,93(2):251-256.
    [22] KaiserSM, Sebag M, Rhim JS,et al.Antisense-mediated inhibition of parathyroid hormone-related peptide production in a keratinocyte cell line impedes differentiation[J].Mol Endocrinol,1994,8(2):139-147.
    [23] Juhlin L, Hagforsen E, Juhlin C.Parathyroid hormone related protein is localized in the granular layer of normal skin and in the dermal infiltrates of mycosis fungoides but is absent in psoriatic lesions[J].Acta Derm Venereol,1992,72(2):81-83.
    [24] Whitfield JF, Chakravarthy BR, Durkin JP,et al.Parathyroid hormone stimulates protein kinase C but not adenylate cyclase in mouse epidermal keratinocytes[J].J Cell Physiol, 1992,150(2):299-303.
    [25] Dore RK.Long-term safety, efficacy, and patient acceptability of teriparatide in the management of glucocorticoid-induced osteoporosis[J].Patient Prefer Adher, 2013,7:435-446.
    [26] Horwitz MJ, Augustine M, Kahn L,et al.A comparison of parathyroid hormone-related protein (1-36) and parathyroid hormone (1-34) on markers of bone turnover and bone density in postmenopausal women: the PrOP study[J].J Bone Miner Res, 2013,28(11):2266-2276.
    [27] Holick MF, Chimeh FN, Ray S.Topical PTH (1-34) is a novel, safe and effective treatment for psoriasis: a randomized self-controlled trial and an open trial[J].Br J Dermatol, 2003,149(2):370-376.
    [28] Peters EM, Foitzik K, Paus R,et al.A new strategy for modulating chemotherapy-induced alopecia, using PTH/PTHrP receptor agonist and antagonist[J].J Invest Dermatol, 2001,117(2):173-178.
  • [1] 薛梅萍, 郑茹萍, 林惠娥, 甘惠贞.  西格列汀联合预混胰岛素治疗脆性糖尿病伴高脂血症疗效和安全性的回顾性研究 . 药学实践与服务, 2018, 36(5): 468-470. doi: 10.3969/j.issn.1006-0111.2018.05.020
    [2] 信如娟, 潘会君, 李莹, 安多朋, 朱全刚.  皮肤病专科医院302例药品不良反应报告分析 . 药学实践与服务, 2018, 36(2): 186-188,191. doi: 10.3969/j.issn.1006-0111.2018.02.020
    [3] 史志辉, 肖会敏, 何悦, 刘洋, 刘海月, 杨旭, 王四旺.  HPLC法测定皮肤病血毒片中7种成分的含量 . 药学实践与服务, 2017, 35(5): 427-432. doi: 10.3969/j.issn.1006-0111.2017.05.010
    [4] 李基明, 张慧芬, 谢辉, 沈彤.  布拉酵母菌防治婴幼儿肺炎继发抗生素相关腹泻的临床研究 . 药学实践与服务, 2014, 32(3): 222-224. doi: 10.3969/j.issn.1006-0111.2014.03.016
    [5] 鲍蕾蕾, 陈海飞, 卞俊, 袁兵.  健步关节胶囊对家兔骨关节病模型相关因子的影响 . 药学实践与服务, 2012, 30(3): 211-212,215. doi: 10.3969/j.issn.1006-0111.2012.03.014
    [6] 刘晓敏, 陈虹.  降钙素基因相关肽与前高血压系统的关系 . 药学实践与服务, 2007, (6): 367-368,385.
    [7] 赵军.  抗生素后效应 . 药学实践与服务, 2003, (1): 37-39.
    [8] 王嘉德, 周淑英, 刘永强, 张志国.  肤乐灵霜的研制与临床应用 . 药学实践与服务, 2002, (2): 75-77.
    [9] 李启宏, 陈晓鸣.  肤康王治疗4种皮肤病疗效观察 . 药学实践与服务, 2000, (3): 189-190.
    [10] 张黎, 芮耀诚.  内皮素受体拮抗剂在心血管病临床应用的可能性 . 药学实践与服务, 1997, (6): 340-344.
    [11] 任渝江, 王冠清, 姜洪贵.  肿痒-抹灵治疗急性软组织损伤及瘙痒性皮肤病100例疗效观察 . 药学实践与服务, 1997, (6): 338-339.
    [12] 陈磊, 洪永福.  抗糖尿病新药－胰高血糖素类肽－1的研究进展 . 药学实践与服务, 1996, (6): 324-326.
    [13] 陈红, 余光宏, 魏梁锋, 朱铨英, 苏定冯.  高血压病与胰岛素抵抗 . 药学实践与服务, 1995, (6): 324-326,358.
    [14] 苏开仲, 张紫洞.  抗生素 . 药学实践与服务, 1988, (4): 4-5.
    [15] R.Imoto.  氨基甙类抗生素治疗严重美尼尔氏病 . 药学实践与服务, 1987, (4): 29-30.
    [16] 郝鹏起.  维生素E的临床应用 . 药学实践与服务, 1986, (4): 18-20.
    [17] 高申, 潘珍如, 张紫洞.  维生素E缺乏 . 药学实践与服务, 1986, (4): 20-21.
    [18] 邹本泽, 崔文海.  维生素A与癌症 . 药学实践与服务, 1985, (1): 22-23.
    [19] 胡学智, 林一鸣.  抗生素药物的缩写 . 药学实践与服务, 1984, (3): 36-39.
    [20] 周龙祥, 苏开仲.  饮食纤维素与十二指肠溃疡病 . 药学实践与服务, 1984, (3): 22-22.
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3242
  • HTML全文浏览量:  220
  • PDF下载量:  114
  • 被引次数: 0
出版历程
  • 收稿日期:  2013-06-13
  • 修回日期:  2013-12-02

甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展

doi: 10.3969/j.issn.1006-0111.2014.06.002
  • 1. 上海市浦东新区公利医院皮肤科, 上海 200135;第二军医大学附属长海医院皮肤科, 上海 200433
  • 2. 第二军医大学附属长海医院皮肤科, 上海 200433
    • 基金项目:  浦东新区卫生系统优秀青年医学人才培养计划(PWRq2013-02).
  • 收稿日期: 2013-06-13
  • 修回日期: 2013-12-02

摘要: 甲状旁腺素(PTH)和甲状旁腺素相关肽(PTHrP)是一类多肽类激素,它们具有相似的基因结构、相同的膜受体,在人体钙、磷代谢过程中起着重要的调节作用。PTH和PTHrP及其受体除表达于肿瘤组织外,在皮肤、毛囊等正常组织也有表达。它们对表皮增殖分化、毛发生长的生理作用等方面,有望成为银屑病等常见皮肤病的治疗新靶点。

English Abstract

卜晓琳, 毕新岭, 徐晓光, 高志祥, 李慧, 顾军. 甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展[J]. 药学实践与服务, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
引用本文: 卜晓琳, 毕新岭, 徐晓光, 高志祥, 李慧, 顾军. 甲状旁腺素和甲状旁腺素相关肽在皮肤病中的研究进展[J]. 药学实践与服务, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
shu
BU Xiaolin, BI Xinling, XU Xiaoguang, GAO Zhixiang, LI Hui, GU Jun. The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
Citation: BU Xiaolin, BI Xinling, XU Xiaoguang, GAO Zhixiang, LI Hui, GU Jun. The research progress of parathyroid hormone and parathyroid hormone-related peptide in skin disease[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(6): 405-408. doi: 10.3969/j.issn.1006-0111.2014.06.002
shu

    全文HTML

参考文献 (28)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计