辐射致组织损伤凋亡机制的研究概况

杨宏; 倪敏; 赵心彬; 陶霞

doi:10.3969/j.issn.1006-0111.2014.02.005

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辐射致组织损伤凋亡机制的研究概况

杨宏, 倪敏, 赵心彬, 陶霞

文章导航 > 药学实践与服务 > 2014 > 32(2): 96-97,149

杨宏, 倪敏, 赵心彬, 陶霞. 辐射致组织损伤凋亡机制的研究概况[J]. 药学实践与服务, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

引用本文:

杨宏, 倪敏, 赵心彬, 陶霞. 辐射致组织损伤凋亡机制的研究概况[J]. 药学实践与服务, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

Citation:

YANG Hong, NI Min, ZHAO Xinbin, TAO Xia. Role of apoptosis in radiation-induced tissue damage[J]. Journal of Pharmaceutical Practice and Service, 2014, 32(2): 96-97,149. doi: 10.3969/j.issn.1006-0111.2014.02.005

辐射致组织损伤凋亡机制的研究概况

doi: 10.3969/j.issn.1006-0111.2014.02.005

第二军医大学附属长征医院药学部, 上海 200003

Role of apoptosis in radiation-induced tissue damage

Department of Pharmacy, Changzheng Hospital Affiliated to Second Military Medical University, Shanghai 200003, China

摘要: 辐射能够导致组织损伤,其机制通常与细胞凋亡、坏死、炎症等相关。其中细胞凋亡是辐射损伤的主要特征之一,但是凋亡发生的具体机制仍不清楚。研究表明,有多条通路涉及其中,代表性的通路有:聚ADP核糖聚合酶(PARP)、p53、自由基、神经酰胺、p38通路等。本文围绕上述蛋白质分子,综述了凋亡途径在辐射致组织损伤的作用。
- 电离辐射 /
- 损伤机制 /
- 细胞凋亡 /
- 脱氧核糖核酸损伤 /
- 神经酰胺
Abstract: Ionizing radiation is able to induce tissue damage, which is related to cell apoptosis, necrosis and inflammation, etc. The signaling pathway underlying radiation-induced apoptosis remains unclear. However, it's well-accepted that several targets were activated in this process, such as poly (ADP-ribose) polymerase, p53, p38, ceramide, free radicals, etc. Based on these targets, the role of apoptosis in radiation-induced tissue damage was elaborated in this review briefly.
- ionizing radiation /
- damage mechanism /
- cell apoptosis /
- DNA damage /
- ceramide

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辐射致组织损伤凋亡机制的研究概况

doi: 10.3969/j.issn.1006-0111.2014.02.005

第二军医大学附属长征医院药学部, 上海 200003

收稿日期: 2013-03-11
修回日期: 2013-06-14

关键词:

摘要: 辐射能够导致组织损伤,其机制通常与细胞凋亡、坏死、炎症等相关。其中细胞凋亡是辐射损伤的主要特征之一,但是凋亡发生的具体机制仍不清楚。研究表明,有多条通路涉及其中,代表性的通路有:聚ADP核糖聚合酶(PARP)、p53、自由基、神经酰胺、p38通路等。本文围绕上述蛋白质分子,综述了凋亡途径在辐射致组织损伤的作用。