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叶酸在心脑血管疾病防治中的机遇与挑战

成彦琼,  张浩,  王威,  顾小飞,  刘爱军

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成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
引用本文: 成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
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CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
Citation: CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
shu

叶酸在心脑血管疾病防治中的机遇与挑战

doi: 10.3969/j.issn.1006-0111.2013.05.003
  • 1.

    第二军医大学长海医院泌尿外科, 上海 200433;第二军医大学药学院药理学教研室, 上海 200433

  • 2.

    第二军医大学药学院药理学教研室, 上海 200433

基金项目: 国家自然科学基金资助项目(81273505).

New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases

  • 1.

    Department of Urology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China;Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    Department of Pharmacology, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 叶酸缺乏可导致高同型半胱氨酸血症,而高同型半胱氨酸血症是心脑血管疾病的独立危险因素。过去认为补充叶酸可降低体内同型半胱氨酸水平,从而预防心脑血管疾病的发生。但随着大量临床随机对照试验的进行,人们发现降低同型半胱氨酸血症并不能为心血管疾病患者带来益处,脑卒中方面的益处还需要更多临床数据证明。叶酸等B族维生素在心脑血管疾病的预防领域还存在着很大的挑战。笔者就目前叶酸等在心脑血管疾病中的应用现状及存在问题作一综述。
    Abstract: The lack of folic acid which could cause hyperhomocysteine had revealed an obviously relationship with cardiovascular and cerebrovascular diseases. Plenty of studies had shown that hyperhomocysteine was an independent risk factor of cardiovascular and cerebrovascular diseases. Folic acid supplementation might be an effective method to decrease homocysteine and prevent cardiovascular and cerebrovascular diseases,while some studies question about it. So there was a new challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases.
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  • 收稿日期:  2012-12-14
  • 修回日期:  2013-04-08

叶酸在心脑血管疾病防治中的机遇与挑战

doi: 10.3969/j.issn.1006-0111.2013.05.003
  • 1. 第二军医大学长海医院泌尿外科, 上海 200433;第二军医大学药学院药理学教研室, 上海 200433
  • 2. 第二军医大学药学院药理学教研室, 上海 200433
    • 基金项目:  国家自然科学基金资助项目(81273505).
  • 收稿日期: 2012-12-14
  • 修回日期: 2013-04-08

摘要: 叶酸缺乏可导致高同型半胱氨酸血症,而高同型半胱氨酸血症是心脑血管疾病的独立危险因素。过去认为补充叶酸可降低体内同型半胱氨酸水平,从而预防心脑血管疾病的发生。但随着大量临床随机对照试验的进行,人们发现降低同型半胱氨酸血症并不能为心血管疾病患者带来益处,脑卒中方面的益处还需要更多临床数据证明。叶酸等B族维生素在心脑血管疾病的预防领域还存在着很大的挑战。笔者就目前叶酸等在心脑血管疾病中的应用现状及存在问题作一综述。

English Abstract

成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
引用本文: 成彦琼, 张浩, 王威, 顾小飞, 刘爱军. 叶酸在心脑血管疾病防治中的机遇与挑战[J]. 药学实践与服务, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
shu
CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
Citation: CHENG Yan-qiong, ZHANG Hao, WANG Wei, GU Xiao-fei, LIU Ai-jun. New challenge of folic acid on prevention of cardiovascular and cerebrovascular diseases[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(5): 330-333,350. doi: 10.3969/j.issn.1006-0111.2013.05.003
shu

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