Study on the hypolipidemic effects of polydatin
-
摘要: 目的 研究白藜芦醇苷的降血脂活性。 方法 通过饲喂高脂饲料建立高脂血症大鼠和家兔动物模型,分别连续给药7 d和14 d,观察白藜芦醇苷对2种动物模型血清总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)水平的影响。 结果 白藜芦醇苷显著降低高血脂家兔血清TC、TG和LDL水平,能明显对抗大鼠升高的血清TG含量。 结论 白藜芦醇苷具有降血脂的作用。Abstract: Objective To investigate the hypolipidemic effects of polydatin on hyperlipidemic animals. Methods The models of hyperlipidemic rabbits and rats were established. Model animals were orally given polydatin for continuous 7 or 14 days and the serum levels of TC, TG, HDL and LDL were evaluated. Results Polydatin significantly decreased the serum levels of TC, TG, and LDL in hyperlipidemic rabbits, and markedly depressed the serum TG level in hyperlipidemic rats. Conclusions Polydatin possessed a favorable hypolipidemic activity.
-
Key words:
- polydatin /
- blood lipid /
- rabbit /
- rat
-
[1] Pan YM, Zhang XP, Wang HS, et al. Antioxidant potential of ethanolic extract of Polygonum cuspidatum and application in peanut oil[J]. Food Chem, 2007, 105(4):1518. [2] Cheng YF, Zhang HT, Sun LS, et al. Involvement of cell adhesion molecules in polydatin protection of brain tissues from ischemia-reperfusion injury[J]. Brain Res, 2006, 1110(1):193. [3] Jordan KC, Freeland-Graves JH, Klohe-Lehman DM, et al. A nutrition and physical activity intervention promotes weight loss and enhances diet attitudes in low-income mothers of young children[J]. Nutr Res, 2008, 28(1):13. [4] Huang ZS, Wang ZW, Liu MP, et al. Protective effects of polydatin against CCl(4)-induced injury to primarily cultured rat hepatocytes[J]. World J Gastroenterol, 1999;5(1):41. [5] 李 锋,王贤波. 茶叶中EGC对高脂大鼠的降血脂作用[J]. 浙江农业科学,2012(1):32. [6] 魏碧娜,黄铭珊,邓元荣,等. 油茶皂苷对高脂血症大鼠血脂的影响[J]. 海峡药学,2011,23(12):38. [7] 刘雪梅,吴符火. 几类高脂血症动物模型的比较[J]. 中西医结合学报,2004,4(4):132. -
点击查看大图
计量
- 文章访问数: 2635
- HTML全文浏览量: 318
- PDF下载量: 71
- 被引次数: 0
下载:
