秦艽总环烯醚萜苷的抗炎作用及其机制

牛筛龙; 孙富增; 张兴耐

doi:10.3969/j.issn.1006-0111.2013.03.010

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

秦艽总环烯醚萜苷的抗炎作用及其机制

牛筛龙, 孙富增, 张兴耐

文章导航 > 药学实践与服务 > 2013 > 31(3): 198-200

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

引用本文:

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

Citation:

NIU Shai-long, SUN Fu-zeng, Zhang Xing-nai. Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

秦艽总环烯醚萜苷的抗炎作用及其机制

doi: 10.3969/j.issn.1006-0111.2013.03.010

武警江苏省总队医院药剂科, 江苏扬州 225003

Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside

Department of Pharmacy, Jiangsu Provincial Corps Hospital of Chinese People's Armed Police Forces, Yangzhou 225003, China

摘要: 目的观察不同浓度秦艽总环烯醚萜(GMI)对各型各期炎症模型的影响,探讨其抗炎作用的可能机制。方法采用二甲苯致耳廓肿胀、醋酸诱发小鼠腹腔毛细血管通透性增高,蛋清致大鼠背部气囊滑膜炎,棉球诱发小鼠肉芽肿模型,探讨GMI的抗炎作用。称体质量测定各组小鼠耳的炎症肿胀程度及肉芽增生水平,用化学方法检测各组小鼠腹腔洗涤液中的伊文思蓝含量、滑膜炎渗出液容积、渗出液中的白细胞(WBC)计数和肿瘤坏死因子(TNF-α)含量,渗出液和血清中超氧化物歧化酶(SOD)、丙二醛(MDA)含量。 结果与结论 与阴性对照组相比,GMI能够抑制二甲苯致小鼠耳廓肿胀、醋酸致小鼠毛细血管通透性的增加,以及小鼠棉球肉芽肿的形成;其较阴性对照组还能明显减少渗出液容积,降低渗出液中WBC、MDA、TNF-α含量及血清中MDA水平,并能提高渗出液和血清中SOD的活性。结论 GMI能够减轻各期炎症形成,机制可能与抑制炎性因子的渗出、消除自由基和抑制脂质过氧化有关。
- 秦艽 /
- 总环烯醚萜苷 /
- 抗炎 /
- 作用机制
Abstract: Objective To observe effects of different concentrations of the Gentiana macrophylla iridoid glucoside(GMI) in different period inflammatory models, and discuss the possibility of anti-inflammation. Methods The anti-inflammatory models of GMI were investigated in mice by methods of the capillary permeability increase (AIPCPI), the cotton-pellet induced-granuloma(CPIG) xylene-induced auricle swelling (XIAS), intraperitoneal injection of acetic acid-induced peritoneal capilnd egg white-induced balloon back synovial inflammation. Levels of XIAS and CPIG in mouse were detected by weighing. Levels of mouse peritoneal washing fluid in the content of Evans blue, synovitis exudate volume, white blood cells(WBC), tumor necrosis factor(TNF-α), the exudate and serum levels of superoxide dismutase(SOD) and malondialdehyde were determined by chemical method respectively. Result Compared with negative control group, levels of XIAS, AIPCPI and CPIG decreased significantly in GMI group. Levels of WBC, MDA and TNF-α significantly decreased in GMI group than those of negative control group, but the activity of the exudate and serum SOD increased significantly in GMI group compared with that of negative control group. Conclusion The GMI showed protective effects on inflammation in animal models, which might be mediated through inhibition of the exudation of inflammatory factors, the lipid peroxidation and the elimination of free radicals.
- G. macrophylla Pall /
- iridoid glucoside /
- anti-inflammatory /
- mechanism

[1]	中国科学院中国植物志编辑委员会.中国植物志,第1版[M].北京:科学出版社,1988:62.
[2]	Tan Rx,Wolfender JL,Zhang LX,et al.Acyl secoiridiods and antifungal constituents from Gentiana macrophylla[J].Phytochem,1996,42(5):1305.
[3]	刘艳红, 李兴从, 刘玉清, 等. 秦艽中的环烯醚萜苷类成分[J].云南植物研究, 1995, 15(1):85.
[4]	张均智,莫刚,杨成芳,等. 茅莓正丁醇组分的抗炎作用[J].中国实验方剂学杂志,2011,17(8):204.
[5]	钱海兵,蒲金山,王龙,等.苗药铁筷子挥发油的抗炎作用研究[J].时珍国医国药,2012,23(8):1961.
[6]	王玮, 白月, 王俊平, 等. 黄芩茎叶总黄酮对大鼠气囊滑膜炎抗炎作用机制的研究[J]. 临床与用药, 2009, 26(4):460.
[7]	韩磊, 向云霞, 徐磊. 中药抗炎与免疫药理[J]. 新疆中医药, 2011, 29(4):114.

[1]	汪麟, 方煜, 余文武, 洪泽. 4种黄山菊花品种的抗氧化和抗炎活性研究 . 药学实践与服务, 2023, 41(5): 325-328. doi: 10.12206/j.issn.2097-2024.202211024
[2]	严啸东, 郭美丽. 黄酮类化合物抗心脑血管缺血性疾病作用的研究进展 . 药学实践与服务, 2022, 40(2): 97-102. doi: 10.12206/j.issn.1006-0111.202111059
[3]	谢彬, 袁星, 徐希科, 柳润辉. 中药复方抗动脉粥样硬化作用机制的研究进展 . 药学实践与服务, 2021, 39(4): 295-298, 304. doi: 10.12206/j.issn.1006-0111.202103001
[4]	俞月, 路娟, 柴瑞平, 吕欣锴, 邓明慧, 陈曦. 基于抗氧化和抗炎生物效应的生脉注射液质量评价 . 药学实践与服务, 2020, 38(2): 143-147. doi: 10.3969/j.issn.1006-0111.201906029
[5]	余璐瑶, 贾丹, 沈慧, 孙晓蕾, 秦路平, 韩婷. 豆豉姜活性成分9,9’-O-二-(E)-阿魏酰基-内消旋-5,5’-二甲氧基开环异落叶松树脂酚（LCA）抗炎作用研究 . 药学实践与服务, 2020, 38(3): 216-220. doi: 10.12206/j.issn.1006-0111.201912159
[6]	徐熠, 刘静, 黄瑾, 崔金刚, 吴铁军. 痛风颗粒各有效部位群对关节炎大鼠的抗炎镇痛作用研究 . 药学实践与服务, 2020, 38(6): 528-532. doi: 10.12206/j.issn.1006-0111.202007015
[7]	豆甲泰, 吕超, 方婷, 张巧艳. 枸骨茎抗炎活性成分研究 . 药学实践与服务, 2018, 36(4): 358-361,368. doi: 10.3969/j.issn.1006-0111.2018.04.016
[8]	聂力, 葛卫红. 白三烯受体拮抗剂改善哮喘患者炎症及免疫功能的效果分析 . 药学实践与服务, 2017, 35(6): 562-564,568. doi: 10.3969/j.issn.1006-0111.2017.06.020
[9]	孙蕾, 邓华平, 席忠新, 李霞, 孙连娜. 抗肝纤维化的中药有效成分及其作用机制研究进展 . 药学实践与服务, 2012, 30(2): 92-95,127. doi: 10.3969/j.issn.1006-0111.2012.02.004
[10]	何希瑞, 李茂星, 尚小飞, 贾正平, 张汝学. 秦艽与龙胆挥发油的化学成分及抗炎活性研究 . 药学实践与服务, 2011, 29(4): 274-277,283.
[11]	路明珠, 张治强, 伊佳, 陈万生, 侯忠海, 李铁军. 知母皂苷B-Ⅱ抗抑郁作用及其机制研究 . 药学实践与服务, 2010, 28(4): 283-287.
[12]	武雪宾, 虞慧华, 唐亮, 尤本明. 通脉愈伤胶囊抗炎镇痛作用的实验研究 . 药学实践与服务, 2010, 28(3): 193-195.
[13]	吴诚, 许惠琴. 镰形棘豆中2′,4′-二羟基查尔酮抗炎止血作用的实验研究 . 药学实践与服务, 2010, 28(6): 431-432,436.
[14]	费逸明, 龚纯贵. 白英提取物镇痛抗炎作用的实验研究 . 药学实践与服务, 2009, 27(2): 111-114.
[15]	朱昱, 韩婷, 张巧艳, 秦路平. 番红花不同药用部位的镇痛和抗炎活性比较研究 . 药学实践与服务, 2008, (4): 269-271.
[16]	黄宝康, 郑汉臣, 秦路平. 缬草属植物的镇静催眠作用及机制 . 药学实践与服务, 2007, (3): 134-136,142.
[17]	王逢春, 张瑞麟. 三萜皂苷的中枢神经系统作用 . 药学实践与服务, 2007, (3): 140-142.
[18]	龚纯贵, 张国庆, 王希营, 雷彦辉. 仙鹤草提取物镇痛抗炎试验的实验研究 . 药学实践与服务, 2006, (6): 339-341,356.
[19]	叶光明, 吴秋业, 姜云云, 俞世冲, 廖红利. 富勒烯在医药领域中的研究进展 . 药学实践与服务, 2004, (2): 73-76.
[20]	黄桂雅, 王海峰, 唐晓东, 张景艳, 张惠政, 陈国平. 消炎片抗菌抗炎作用的研究 . 药学实践与服务, 2001, (2): 81-82,80.

点击查看大图

计量

文章访问数: 2984
HTML全文浏览量: 356
PDF下载量: 71
被引次数: 0

秦艽总环烯醚萜苷的抗炎作用及其机制

doi: 10.3969/j.issn.1006-0111.2013.03.010

武警江苏省总队医院药剂科, 江苏扬州 225003

收稿日期: 2012-11-20
修回日期: 2013-04-10

关键词:

秦艽 /

总环烯醚萜苷 /

抗炎 /

作用机制

摘要: 目的观察不同浓度秦艽总环烯醚萜(GMI)对各型各期炎症模型的影响,探讨其抗炎作用的可能机制。方法采用二甲苯致耳廓肿胀、醋酸诱发小鼠腹腔毛细血管通透性增高,蛋清致大鼠背部气囊滑膜炎,棉球诱发小鼠肉芽肿模型,探讨GMI的抗炎作用。称体质量测定各组小鼠耳的炎症肿胀程度及肉芽增生水平,用化学方法检测各组小鼠腹腔洗涤液中的伊文思蓝含量、滑膜炎渗出液容积、渗出液中的白细胞(WBC)计数和肿瘤坏死因子(TNF-α)含量,渗出液和血清中超氧化物歧化酶(SOD)、丙二醛(MDA)含量。 结果与结论 与阴性对照组相比,GMI能够抑制二甲苯致小鼠耳廓肿胀、醋酸致小鼠毛细血管通透性的增加,以及小鼠棉球肉芽肿的形成;其较阴性对照组还能明显减少渗出液容积,降低渗出液中WBC、MDA、TNF-α含量及血清中MDA水平,并能提高渗出液和血清中SOD的活性。结论 GMI能够减轻各期炎症形成,机制可能与抑制炎性因子的渗出、消除自由基和抑制脂质过氧化有关。

English Abstract

Anti-inflammatory mechanisms of Gentiana macrophylla iridoid glucoside

Department of Pharmacy, Jiangsu Provincial Corps Hospital of Chinese People's Armed Police Forces, Yangzhou 225003, China

Received Date: 2012-11-20
Rev Recd Date: 2013-04-10

Keywords:

Abstract: Objective To observe effects of different concentrations of the Gentiana macrophylla iridoid glucoside(GMI) in different period inflammatory models, and discuss the possibility of anti-inflammation. Methods The anti-inflammatory models of GMI were investigated in mice by methods of the capillary permeability increase (AIPCPI), the cotton-pellet induced-granuloma(CPIG) xylene-induced auricle swelling (XIAS), intraperitoneal injection of acetic acid-induced peritoneal capilnd egg white-induced balloon back synovial inflammation. Levels of XIAS and CPIG in mouse were detected by weighing. Levels of mouse peritoneal washing fluid in the content of Evans blue, synovitis exudate volume, white blood cells(WBC), tumor necrosis factor(TNF-α), the exudate and serum levels of superoxide dismutase(SOD) and malondialdehyde were determined by chemical method respectively. Result Compared with negative control group, levels of XIAS, AIPCPI and CPIG decreased significantly in GMI group. Levels of WBC, MDA and TNF-α significantly decreased in GMI group than those of negative control group, but the activity of the exudate and serum SOD increased significantly in GMI group compared with that of negative control group. Conclusion The GMI showed protective effects on inflammation in animal models, which might be mediated through inhibition of the exudation of inflammatory factors, the lipid peroxidation and the elimination of free radicals.

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

引用本文:

牛筛龙, 孙富增, 张兴耐. 秦艽总环烯醚萜苷的抗炎作用及其机制[J]. 药学实践与服务, 2013, 31(3): 198-200. doi: 10.3969/j.issn.1006-0111.2013.03.010

Citation: