脉冲释放制剂组合的数学解析

邹豪; 刘俊杰; 陈琰; 鲁莹; 张川; 钟延强

doi:10.3969/j.issn.1006-0111.2013.02.005

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脉冲释放制剂组合的数学解析

邹豪, 刘俊杰, 陈琰, 鲁莹, 张川, 钟延强

文章导航 > 药学实践与服务 > 2013 > 31(2): 98-101,107

邹豪, 刘俊杰, 陈琰, 鲁莹, 张川, 钟延强. 脉冲释放制剂组合的数学解析[J]. 药学实践与服务, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005

引用本文:

邹豪, 刘俊杰, 陈琰, 鲁莹, 张川, 钟延强. 脉冲释放制剂组合的数学解析[J]. 药学实践与服务, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005

ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang. Modulation of combined-release behaviors from pulsatile release tablet[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005

Citation:

ZOU Hao, LIU Jun-jie, CHEN Yan, LU Ying, ZHANG Chuan, ZHONG Yan-qiang. Modulation of combined-release behaviors from pulsatile release tablet[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 98-101,107. doi: 10.3969/j.issn.1006-0111.2013.02.005

脉冲释放制剂组合的数学解析

doi: 10.3969/j.issn.1006-0111.2013.02.005

第二军医大学药学院, 上海 200433

基金项目: 国家自然科学基金(30801441);"重大新药创制"科技重大专项(2008ZXJ09010-001,2008ZXJ09002-010)

Modulation of combined-release behaviors from pulsatile release tablet

School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 目的本研究采用数学手段对脉冲释放制剂的释药行为进行解析,根据两种制剂释药速率经时方程迭加的原理,构建组合系统的释药速率经时方程。方法按照最小偏差平方和SS原则,采用非线性最小二乘法模型嵌合通用程序,对组合系统进行模型嵌合,得到最适模型的释药速率经时方程,并据方程绘制释药速率经时曲线。结果以两种脉冲释放制剂的配比为1:1的组合系统释药较平缓,而此时两次脉冲的释放速度比较接近。结论以短时缓释片芯为基础的脉冲组合型缓释制剂在改善不同组分释药同步性的同时,释药速率波动相对比较平缓。
- 脉冲释放制剂 /
- 数学解析 /
- 最小二乘法模型
Abstract: Objective To design and evaluate a multifunctional and multiple unit oral DDS, which depends on the preparations of pulsatile release mini-tablets. Methods Based on the combinations of pulsatile release tablets, zero-order DDS could be obtained. Velocity-time curve, instead of the cumulative percentage drug release profile, was plotted. The nonlinear least square model fit program was applied to process the velocity data of dissolution. The test curves coincided with the theoretical curves from simple summation of v-t equations of individual pulsatile release tablets. Results Zero-order DDS were designed with two kinds of combinations. The amount of the two pulsatile should be 1:1. The combination of pulsatile release tablet could achieved the formulation from which Acetaminophen and Pseudoephedrine could be released in the same proportion. Conclusion The combination of delayed-onset sustained-release Tablet was better fit in with zero-order equation and Acetaminophen and Pseudoephedrine could be released in the same proportion.
- tpulsatile release tablet /
- velocity-time curve /
- nonlinear least square model

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脉冲释放制剂组合的数学解析

doi: 10.3969/j.issn.1006-0111.2013.02.005

第二军医大学药学院, 上海 200433

基金项目: 国家自然科学基金(30801441);"重大新药创制"科技重大专项(2008ZXJ09010-001,2008ZXJ09002-010)

收稿日期: 2012-07-05
修回日期: 2012-10-29

关键词:

脉冲释放制剂 /

数学解析 /

最小二乘法模型

摘要: 目的本研究采用数学手段对脉冲释放制剂的释药行为进行解析,根据两种制剂释药速率经时方程迭加的原理,构建组合系统的释药速率经时方程。方法按照最小偏差平方和SS原则,采用非线性最小二乘法模型嵌合通用程序,对组合系统进行模型嵌合,得到最适模型的释药速率经时方程,并据方程绘制释药速率经时曲线。结果以两种脉冲释放制剂的配比为1:1的组合系统释药较平缓,而此时两次脉冲的释放速度比较接近。结论以短时缓释片芯为基础的脉冲组合型缓释制剂在改善不同组分释药同步性的同时,释药速率波动相对比较平缓。