人类乙醛脱氢酶II及其激动剂的研究进展

田巍; 王涛; 郑灿辉; 董国强; 吕加国; 朱驹

doi:10.3969/j.issn.1006-0111.2013.02.004

留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

x 关闭永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

人类乙醛脱氢酶II及其激动剂的研究进展

田巍, 王涛, 郑灿辉, 董国强, 吕加国, 朱驹

文章导航 > 药学实践与服务 > 2013 > 31(2): 94-97,112

田巍, 王涛, 郑灿辉, 董国强, 吕加国, 朱驹. 人类乙醛脱氢酶II及其激动剂的研究进展[J]. 药学实践与服务, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004

引用本文:

TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004

Citation:

TIAN Wei, WANG Tao, ZHENG Can-hui, DONG Guo-qiang, LV jia-guo, ZHU Ju. Progress on Human aldehyde dehydrogenase II and its agonists[J]. Journal of Pharmaceutical Practice and Service, 2013, 31(2): 94-97,112. doi: 10.3969/j.issn.1006-0111.2013.02.004

人类乙醛脱氢酶II及其激动剂的研究进展

doi: 10.3969/j.issn.1006-0111.2013.02.004

第二军医大学药学院药物化学教研室, 上海 200433

Progress on Human aldehyde dehydrogenase II and its agonists

Department of Medicinal Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China

摘要: 人类乙醛脱氢酶II (aldehyde dehydrogenasesII,ALDH2) 具有脱氢酶和酯酶等多种酶的功能,ALDH2活性的增强将减轻因酒精、缺血等多种因素引起的肝脏、心肌损伤及某些癌症的发生。本文通过对国内外文献的分析、整理和归纳,较为全面的介绍了ALDH2及其激动剂的研究现状。
- 乙醛脱氢酶II(ALDH2) /
- 激动剂 /
- 阿尔达-1
Abstract: The aldehyde dehydrogenase II (ALDH2) could act as both esterase and dehydrogenase. The improvement of ALDH2 activity might reduce the damage caused by alcohol and ischemia and avoid the occurrence of some certain cancers. The outline of ALDH2 and its agonists were summarized concisely through literature analysis, collation and induction in this paper.
- aldehyde dehydrogenase II (ALDH2) /
- agonist /
- alda-1

[1]	毛根年,李鑫,瞿建波.乙醛脱氢酶及其医疗领域研究进展[J].天然产物研究与开发,2011,23:193.
[2]	Wojciech J, Emilia K, Magdalena LD, et al. Alcohol Dehydrogenase (ADH) and Aldehyde Dehydrogenase (ALDH) as Candidates for Tumor markers in Patients with Pancreatic Cancer[J]. J Gastrointestin Liver Dis,2011, 20:255.
[3]	Jose C,Jimenez L, Emma WG, et al.The maize ALDH protein superfamily:linking structural features to functional specificities[J]. BMC Structural Biology,2010, 10:43.
[4]	何岚,彭军.线粒体醛脱氢酶对心脏保护作用的研究进展[J].中国药理学通报,2009,25:1548.
[5]	罗怀荣,张亚平.乙醛脱氢酶2(ALDH2)基因研究进展及其与饮酒行为的关系[J].遗传,2004,26:263.
[6]	Che HC, Li HS, Daria MR. Mitochondrial aldehyde dehydrogenase and cardiac diseases[J]. Cardiovascular Research,2010,88:51.
[7]	Samantha PM, Hina YRV, Che HC, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology,2010,17:159.
[8]	Chen CB.Crystal structure of aldehyde dehydrogenase and methods 0f use tilereof[J].World intellectual property organization,2009,18:1.
[9]	Curtis GS, Pei X, Henry W,et al.Structure of mitochondrial aldehyde dehydrogenase:the genetic component of ethanol aversion[J]. Structure,1997,5:701.
[10]	Jiali W, Haigang W, Panpan H, et al. Inhibition of Aldehyde Dehydrogenase 2 by Oxidative Stress Is Associated with Cardiac Dysfunction in Diabetic Rats[J]. MOL MED, 2011,17:172.
[11]	Grant RB, Marie HD, Daria MR,et al. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
[12]	刘非凡,唐瑛,陈忠庆,等.地塞米松治疗双硫仑样反应的临床和实验研究[J]. 内科急危重症杂志,2008,14:205.
[13]	陈玉国,张运.乙醛脱氢酶2与硝酸酯耐药关系的研究进展[J].心血管病学进展,2010,31:50.
[14]	Martin WH, Sonja S, Michael W, et al. Inhibition of aldehyde dehydrogenase type 2 attenuates vasodilatory action of nitroglycerin in human veins[J]. The FASEB Journal, 2008,22:2561.
[15]	王群英,刘新伟.硝酸甘油及线粒体乙醛脱氢酶对心肌保护作用的研究进展[J].心血管病学进展,2010,31:708.
[16]	Grant RB, Marie HD, Che HC, et al. Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon knockout mice[J]. Journal of Molecular and Cellular Cardiology,2010,48:757.
[17]	Eric NC, Marie HD, Daria MR. Time-dependent and ethanol-induced cardiac protection from ischemia mediated by mitochondrial translocation of εPKC and activation of aldehyde dehydrogenase 2 [J]. J Mol Cell Cardiol, 2009, 46:278.
[18]	Che H C, Lihan S, Daria MR. Mitochondrial aldehyde dehydrogenase and cardiac diseases[J]. Cardiovascular Research,2010, 88:51.
[19]	Perez M, Samantha YH, Vanam R, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology,2010, 17:159.
[20]	Matteo B, Antonius CF, Gorren M, et al. Characterization of the East Asian Variant of Aldehyde Dehydrogenase-2[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2010,285:943.
[21]	Grant RB, Marie HD, Daria MR. Aldehyde Dehydrogenase 2 in Cardiac Protection:A New Therapeutic Target[J]. TCM, 2009,19:159.
[22]	Samantha PM, Hina Y, Ram V, et al. Alda-1 is an agonist and chemical chaperone for the common human aldehyde dehydrogenase 2 variant[J]. Nature Structural & Molecular Biology, 2010,17:159.
[23]	Feldman RI, Weiner H. Horse liver aldehyde dehydrogenaseII Kinetics and mechanistic implications of the dehydrogenase and esterase activity[J]. J Biol Chem, 1972,5:267.
[24]	Takahashi K,Weiner W. Nicotinamide adenine dinucleotide activation of the esterase reaction of horse liver aldehyde dehydrogenase dehydrogenase[J].Biochemistry,1981,20:2720.
[25]	Mukerjee N,Pietruszko R. Human mitochondrial aldehyde dehydrogenase substrate specificity:comparison of esterase with dehydrogenase reaction[J]. Arch Biochem Biophys, 1992, 299:23.
[26]	Perez MS, Hurley TD. Coenzyme isomerization is integral to catalysis in human aldehyde dehydrogenase[J]. Biochemistry, 2003,42:7100.
[27]	Hammen PK, Allali HA, Hallenga K, et al. Multiple conformations of NAD and NADH when bound to human cytosolic and mitochondrial aldehyde dehydrogenase[J]. Biochemistry,2002,41:7156.
[28]	Suzuki Y, Ogawa S,Sakakibara Y. Chaperone therapy for neuronopathic lysosomal diseases:competitive inhibitors as chemical chaperones for enchancement of mutant enzyme activities[J]. Perspect Medicin Chem, 2009,3:7.
[29]	Lowe ED, Gao GY, Johnson LN,et al. Structure of daidzin, a naturally occurring anti-alcohol-addiction agent in complex with human mitochondrial aldehyde dehydrogenase[J]. J Med Chem,2008,51:4482.
[30]	Eun JC, Hak CK, Young CS, et al. Four Flavonoids from Echinosophora koreensis and their Effects on Alcohol Metabolizing Enzymes[J]. Arch Pharm Res, 2009, 32:851.
[31]	汤子春,邹坤,陆海华.开口箭与筒鞘蛇菰提取物醒酒作用机制的研究[J].时珍国医国药,2007,18:2958.

点击查看大图

计量

文章访问数: 3554
HTML全文浏览量: 500
PDF下载量: 333
被引次数: 0

人类乙醛脱氢酶II及其激动剂的研究进展

doi: 10.3969/j.issn.1006-0111.2013.02.004

第二军医大学药学院药物化学教研室, 上海 200433

收稿日期: 2012-04-26
修回日期: 2012-11-12

关键词:

乙醛脱氢酶II(ALDH2) /

激动剂 /

阿尔达-1

摘要: 人类乙醛脱氢酶II (aldehyde dehydrogenasesII,ALDH2) 具有脱氢酶和酯酶等多种酶的功能,ALDH2活性的增强将减轻因酒精、缺血等多种因素引起的肝脏、心肌损伤及某些癌症的发生。本文通过对国内外文献的分析、整理和归纳,较为全面的介绍了ALDH2及其激动剂的研究现状。