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同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系

段迪,  凌迎春,  周月琴,  王玲英

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段迪, 凌迎春, 周月琴, 王玲英. 同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系[J]. 药学实践与服务, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
引用本文: 段迪, 凌迎春, 周月琴, 王玲英. 同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系[J]. 药学实践与服务, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
shu
DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
Citation: DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
shu

同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系

doi: 10.3969/j.issn.1006-0111.2012.03.017

  • 浙江省绍兴市第七人民医院,浙江 绍兴 312000

The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose

  • Department of Psychiatry, the 7th people's hospital of Shaoxing, Shaoxing 312000, China

  • 摘要: 目的 研究喹硫平同等剂量治疗精神分裂症时的稳态血药浓度与临床疗效间的关系。 方法 以固定剂量喹硫平(600 mg/d)治疗148例精神分裂症患者,疗效和不良反应采用简明精神病评定量表(BPRS)和副反应量表(TESS)进行评定,同时测定治疗第2、4、8周的稳态血清药物浓度。 结果 精神分裂症患者的BPRS减分率与血药浓度之间差异有显著性(P＜0.05),血药浓度与不良反应(TESS分值)之间差异无显著性(P＞0.05)。 结论 喹硫平的血药浓度检测有助于确定药物有效浓度
    Abstract: Objective To study the relationship between steady-state plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose. Methods 148 schizophrenia patients were treated with quetiapine with the same dose (600 mg/d). The clinical efficacy and adverse reactions were evaluated with BPRS and TESS respectively, while the plasma concentration of quetiapine was tested at 2nd, 4th and 8th weekend. Results The plasma concentration of quetiapine had significant difference with the reduced rate of BPRS (P<0.05), but had no difference with the scores of TESS. Conclusions The testing of plasma concentration could help to distinguish the effective and toxic concentration of quetiapine in treatment of schizophrenia, which could help doctors to choose rational dose of quetiapine for each patients.
  • [1] 李文标,薛亚振,翟屹民,等,高效液相色谱紫外检测法测定奎硫平血清浓度[J].药物分析杂志,2003,23:247.
    [2] Hirsch SR, Link CG, Goldstein JM, et.al.ICI204, 636: a new atypical antipsychotic drug[J].Br J Psychiatry Suppl, 1996,29:45.
    [3] 喻东山.药物副反应量表的因子重组[J].四川精神卫生,1998,11(3):193.
    [4] 林建荣,董煜坤,陈国中,等,奎硫平和奋乃静治疗精神分裂症老年患者的对照研究[J].中华精神科杂志,2002,35(2):99.
    [5] 唐茂芹,胡 蕾,王松波,等,奎硫平治疗精神分裂症的血药浓度与临床疗效关系的研究[J].中华精神科杂志,2004,37(2):85.
    [6] Meyer JM. Novel antipsychotics and severe hyperlipidemia[J].Clin Psychopharmacol, 2001,21:369.
    [7] Kaneda Y, Ohmori T. Effects of quetiapine on gonadal axis hormones in male patients with schizophrenia: a preliminary, open study[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2003,27:875.
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    [2] 张晶晶, 索丽娜, 郑兆红.  89例细菌性肝脓肿的临床特征及抗感染治疗分析 . 药学实践与服务, 2024, 42(6): 267-272. doi: 10.12206/j.issn.2097-2024.202302039
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出版历程
  • 收稿日期:  2011-10-24
  • 修回日期:  2012-03-05

同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系

doi: 10.3969/j.issn.1006-0111.2012.03.017
  • 浙江省绍兴市第七人民医院,浙江 绍兴 312000
  • 收稿日期: 2011-10-24
  • 修回日期: 2012-03-05

摘要: 目的 研究喹硫平同等剂量治疗精神分裂症时的稳态血药浓度与临床疗效间的关系。 方法 以固定剂量喹硫平(600 mg/d)治疗148例精神分裂症患者,疗效和不良反应采用简明精神病评定量表(BPRS)和副反应量表(TESS)进行评定,同时测定治疗第2、4、8周的稳态血清药物浓度。 结果 精神分裂症患者的BPRS减分率与血药浓度之间差异有显著性(P＜0.05),血药浓度与不良反应(TESS分值)之间差异无显著性(P＞0.05)。 结论 喹硫平的血药浓度检测有助于确定药物有效浓度

English Abstract

段迪, 凌迎春, 周月琴, 王玲英. 同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系[J]. 药学实践与服务, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
引用本文: 段迪, 凌迎春, 周月琴, 王玲英. 同等剂量喹硫平治疗精神分裂症的血药浓度与临床疗效的关系[J]. 药学实践与服务, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
shu
DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
Citation: DUAN Di, LING Ying-chun, ZHOU Yue-qin, WANG Ling-ying. The relationship between plasma concentration and clinical efficacy of quetiapine in treatment of schizophrenia with the same dose[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(3): 218-219. doi: 10.3969/j.issn.1006-0111.2012.03.017
shu

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