留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码
x 关闭 永久关闭

应中央军委要求，2022年9月起，《药学实践杂志》将更名为《药学实践与服务》，双月刊，正文96页；2023年1月起，拟出版月刊，正文64页，数据库收录情况与原《药学实践杂志》相同。欢迎作者踊跃投稿！

微针透皮给药系统应用研究进展

万展,  周剑,  韩美娜,  杨峰

downloadPDF
文章导航 > 药学实践与服务  > 2012 >  30(2): 86-88,142
万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
  • 1.

    河北北方学院基础医学院, 河北 张家口 075000;第二军医大学药学院, 上海 200433

  • 2.

    重庆医科大学药学院, 重庆 400331;第二军医大学药学院, 上海 200433

  • 3.

    第二军医大学药学院, 上海 200433

基金项目: 上海高校选拔培养优秀青年教师科研专项基金(egd09014).

Progress on micro-needles transdermal drug delivery system

  • 1.

    School of Basic Medical Sciences, Hebei North University, Zhangjiakou 075000, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 2.

    School of Pharmacy, Chongqing Medical University, Chongqing 400331, China;School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 3.

    School of Pharmacy, Second Military Medical University, Shanghai 200433, China

  • 摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。
    Abstract: Micro-needles transdermal drug delivery system became the hot spot in the field of transdermal drug delivery system, which had the double advantages in both injection drug delivery and transdermal drug delivery. It also had the merits of fast absorption, continence and painless utility in clinical. Research indicated both transdermal speed and dose of drugs were highly increased when micro-needles transdermal drug delivery system was applied, which especially showed outstanding effects and promise in the preparation of drugs composed of protein, polypeptide, DNA and RNA, etc. Latest developments of micro-needles transdermal drug delivery system were reviewed in this paper. With the development of the industrial arts of the micro-needle, drug delivery technology and application research, micro-needles transdermal drug delivery system would be extensively employed in clinical field.
  • [1] Henry S, McAllister DV, Allen MG, et al. Microfabricated microneedles : a novel approach to transdermal drug delivery[J]. J Pharmacol Sci,1998,87(8):922.
    [2] Mark RP, Robert L. Transdermal drug delivery[J].Nat Biotechnol,2008,26(11):1261.
    [3] Kalluri H, Banga AK. Transdermal delivery of proteins[J]. AAPS Pharmscitech, 2011.12(1):431.
    [4] Zhu QY,Zarnitsyn VG,Ye L,et al.Immunization by vaccine-coated microneedle arrays protects against lethal influenza virus challenge[J].Proc Natl Acad Sci USA,2009,106(19):7968.
    [5] Kaushik S, Hord AH, Denson DD, et al. Lack of pain associated with microfabricated microneedles[J]. Anesth.Analg,2001,92(2):502.
    [6] Ding Z,Riet V,Romeijn S,et al.Immune modulation by adjuvants combined with diphtheria toxoid administered topically in BALB／c mice after microneedle array pretreatment [J].Pharm Res,2009,26(7):163.
    [7] Sullivan SP, Koutsonanos DG,Del Pilar Martin M, et al.Dissolving polymer microneedle patches for influenza vaccination[J].Nat Med,2010,16(8):915.
    [8] Quan FS,Kim YC, Compans RW,et al. Dose sparing enabled by skin immunization with influenza virus-like particle vaccine using microneedles[J].J Controlled Release,2010,147(3):326.
    [9] Hiraishi Y,Nandakumar S,Choi SO,et al.Bacillus Calmette-Guerin vaccination using a microneedle patch[J].Vaccine,2011,29(14):2626.
    [10] Nordquist L,Roxhed N,Griss P,et al.ovel microneedle patches for active insulin delivery are efficientin maintaining glycaemic control:an initial comparison with ubcutaneous administration[J].Pharm Res,2007,24(7):1381.
    [11] Chen HB, Zhu HD,Zheng JN,et al. Iontophoresis-driven penetration of nanovesicles through microneedle induced skin microchannels for enhancing transdermal delivery of insulin[J]. J Controlled Release,2009,139(1):63.
    [12] Gupta J,Felner EI,Prausnitz MR.Rapid pharmacokinetics of intradermal insulin administered using microneedles in type 1 diabetes subjects[J].Diabetes Technol Ther,2011 13(4):451.
    [13] You X,Chang Jong-hyeon,Ju Byeong-Kwon,et al.Rapidly dissolving fibroin microneedles for transdermal drug delivery[J]. Mater Sci Eng.,C 2011,31(8):1632.
    [14] Qin G, Gao Y, Wu Y,et al.Simultaneous basal-bolus delivery of fast-acting insulin and its significance in diabetes management[J].Nanomedicine:NBM 2011,doi: 10.1016/j.nano.2011.05.017.
    [15] Harvey AJ,Kaestner SA,Sutter DE,et al.Microneedle-based intradermal delivery enables rapid lymphatic uptake and distribution of protein drugs[J].Pharm Res,2011,28(1):107.
    [16] Pearton M, Allender C, Brain K,et al.Gene delivery to the epidermal cells of human skin explants using microfabricated microneedles and hydrogel formulations[J]. Pharm Res,2008,25(2):407.
    [17] Gill HS, Soderholm J,Prausnitz MR,et al.Cutaneous vaccination using microneedles coated with hepatitis C DNA vaccine[J]. Gene Ther,2010,17(6):811.
    [18] Chen X,Kask AS,Crichton ML,et al.Improved DNA vaccination by skin-targeted delivery using dry-coated densely-packed microprojection arrays[J].J Controlled Release,2010,148(3):321.
    [19] Kask AS,Chen X,Marshak JO,et al.DNA vaccine delivery by densely-packed and short microprojection arrays to skin protects against vaginal HSV-2 challenge[J].Vaccine,2010,28(47):7483.
    [20] Gonzalez-Gonzalez E, Speaker TJ,Hickerson RP,et al.Silencing of reporter gene expression in skin using siRNAs and Expression of plasmid DNA delivered by a soluble protrusion array device[J]. Mol Ther,2010,18(9):1667.
    [21] Donnelly RF,Morrow DI,Fay F,et al.Microneedle-mediated intradermal nanoparticle delivery:potential for enhanced local administration of hydrophobic pre-formed photosensitisers[J].Photodiagnosis Photodyn Ther,2010,7(4):222.
    [22] Ito Y,Murano H,Hamasaki N,et al.Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles[J].Int J Pharm,2011,407(1-2):126.
    [23] Baek C,Han M,Min J,et al.Local transdermal delivery of phenylephine to the anal sphincter muscle using microneedles[J].J Controlled Release,2011,154(2):138.
    [24] Milewski M,Yerramreddy TR,Ghosh P,et al.In vitro permeation of apegylated naltrexone prodrug across microneedle-treated skin[J].J Controlled Release,2010,146(1):37.
  • [1] 陈亭如, 毛士龙.  体内药物分析技术在临床药学工作中的应用进展 . 药学实践与服务, 2024, 42(2): 60-65. doi: 10.12206/j.issn.2097-2024.202305039
    [2] 陈兰, 何晓莉, 游飘雪, 王辉, 洪战英.  基于微流控芯片的体外肠道吸收模型构建及其应用进展 . 药学实践与服务, 2024, 42(2): 43-49, 59. doi: 10.12206/j.issn.2097-2024.202305003
    [3] 蒋薇薇, 杨峰.  离子导入给药的研究进展 . 药学实践与服务, 2023, 41(4): 212-217, 233. doi: 10.12206/j.issn.2097-2024.202208008
    [4] 陈开宇, 李新平, 陈盛新.  正电子放射性药物的应用现状与进展 . 药学实践与服务, 2012, 30(3): 175-177. doi: 10.3969/j.issn.1006-0111.2012.03.006
    [5] 夏爱晓, 宋倩倩, 孙渊.  固体脂质纳米粒制备及应用研究进展 . 药学实践与服务, 2012, 30(5): 331-333,368. doi: 10.3969/j.issn.1006-0111.2012.05.003
    [6] 张丽莎.  国外药学相关数据库主题类目应用研究 . 药学实践与服务, 2010, 28(4): 251-254,287.
    [7] 涂晔, 王冬, 肖永恒, 崔黎丽.  透皮贴剂制品及研究进展 . 药学实践与服务, 2010, 28(3): 161-163,188.
    [8] 陈建明, 杨秋霞.  纳米给药系统在军队特需药品研究中的应用 . 药学实践与服务, 2010, 28(2): 81-83,93.
    [9] 章凤君, 孙皎.  应用五常法,提高药品管理质量 . 药学实践与服务, 2009, 27(5): 382-383.
    [10] 蒋李, 曹洪江, 高伟.  苦碟子注射液致病人头痛眩晕1例 . 药学实践与服务, 2008, (2): 96-96.
    [11] 张丽娜, 凌沛学, 娄红祥, 张天民.  木瓜酶及其在医药中的应用 . 药学实践与服务, 2007, (6): 361-363.
    [12] 孙志杰.  甲壳化学的研究进展与应用概况 . 药学实践与服务, 2005, (5): 257-262.
    [13] 韩冬, 班春林, 崔黎丽, 李国栋.  微透析技术及在药学中的应用进展 . 药学实践与服务, 2005, (3): 139-142.
    [14] 吉小欣, 高申.  妥洛特罗经皮给药系统的研究进展 . 药学实践与服务, 2004, (6): 324-326.
    [15] 王建, 钟延强.  乙醇脂质体透皮作用的研究与发展 . 药学实践与服务, 2003, (5): 275-277.
    [16] 曹琴, 丁志建, 丁雪鹰, 高申.  非甾体抗炎药透皮给药的研究进展 . 药学实践与服务, 2003, (3): 147-149.
    [17] 闵庆旺, 陈培让, 谭生建, 王建社.  药品快速定性检验监督箱的研制与应用 . 药学实践与服务, 2000, (2): 124-125.
    [18] 梁竹, 黄元, 邹弘颖.  抗骨质疏松药物应用现状及进展 . 药学实践与服务, 2000, (2): 73-74.
    [19] 何荣连.  替硝唑的药理与制剂的开发和应用 . 药学实践与服务, 2000, (4): 206-208.
    [20] 周建标, 周云柏, 王之法.  聚维酮碘在消毒和抗感染中的应用 . 药学实践与服务, 1999, (5): 271-273.
  • 加载中
WeChat 点击查看大图
计量
  • 文章访问数:  3422
  • HTML全文浏览量:  211
  • PDF下载量:  1243
  • 被引次数: 0
出版历程
  • 收稿日期:  2011-09-01
  • 修回日期:  2011-12-06

微针透皮给药系统应用研究进展

doi: 10.3969/j.issn.1006-0111.2012.02.002
  • 1. 河北北方学院基础医学院, 河北 张家口 075000;第二军医大学药学院, 上海 200433
  • 2. 重庆医科大学药学院, 重庆 400331;第二军医大学药学院, 上海 200433
  • 3. 第二军医大学药学院, 上海 200433
    • 基金项目:  上海高校选拔培养优秀青年教师科研专项基金(egd09014).
  • 收稿日期: 2011-09-01
  • 修回日期: 2011-12-06

摘要: 微针透皮给药系统是近年来透皮给药系统研究的热点。微针透皮给药系统具有注射给药和透皮给药的双重优势,具有快速、方便、无痛等众多优点,研究表明可以显著提高药物透皮速率和吸收量,特别是在蛋白质、多肽、DNA和RNA等大分子物质的透皮制剂研究领域表现出良好的效果和应用前景,本文对微针透皮给药系统应用研究的最新进展进行了综述。随着微针加工技术、载药技术和应用研究的不断深入,微针透皮技术在临床领域将会有更广泛的应用。

English Abstract

万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
引用本文: 万展, 周剑, 韩美娜, 杨峰. 微针透皮给药系统应用研究进展[J]. 药学实践与服务, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu
WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
Citation: WAN Zhan, ZHOU Jian, HAN Mei-na, YANG Feng. Progress on micro-needles transdermal drug delivery system[J]. Journal of Pharmaceutical Practice and Service, 2012, 30(2): 86-88,142. doi: 10.3969/j.issn.1006-0111.2012.02.002
shu

    全文HTML

参考文献 (24)

目录

    /

    返回文章
    返回

    版权所有：《药学实践与服务》编辑委员会

    主管、主办: 中国人民解放军海军军医大学地址: 上海市杨浦区国和路325号邮政编码: 200433

    电话: （021）81871324,81871397 E-mail: yxsjzzs@163.com

    网站备案号 沪ICP备05003363号-1

    本系统由 北京仁和汇智信息技术有限公司 开发    百度统计