细胞外激活纳米载药系统研究进展

王晓宇; 高静; 张玮; 朱全刚; 武鑫; 高申

doi:10.3969/j.issn.1006-0111.2012.01.002

细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002

王晓宇¹,
高静²,
张玮³,
朱全刚¹,
武鑫¹,
高申^1,

1.
第二军医大学长海医院药学部,上海 200433
2.
第二军医大学药学院药剂学教研室,上海 200433
3.
解放军第522医院,河南洛阳 471003

基金项目: 国家自然科学基金(81172514,30873178).

Progress on extracellularly activated nanocarriers

1.
Department of Pharmacy,Changhai Hosptial,Second Military Medical University,Shanghai 200433, China
2.
Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China
3.
The 522th Hospital of PLA,Luoyang,Henan 471003,China

摘要: 隐蔽性和靶向性对于纳米载体能否高效、选择性的递送药物非常重要,然而,传统方法难以让纳米载体同时具备这两种性质。新型靶向技术的迅速发展有望克服这一难点。本文在回顾传统靶向技术,阐述其取得的成果和面临的瓶颈的同时,着重讨论了利用环境刺激来激活的新型纳米载体的研究进展。
- 肿瘤靶向 /
- 纳米载体 /
- 细胞外激活 /
- 环境刺激
Abstract: Both the stealth and targeting features were important for effective and selective drug delivery to the tumors.However, it was difficult to achieve both features simultaneously. Some of the novel targeting strategies had the potential to overcome this challenge. The new targeting technologies with recent examples were reviewed, which utilized the environmental stimuli to activate the nanocarriers. Traditional strategies for tumor-targeted nanocarriers were briefly discussed with an emphasis on their achievements and challenges.
- tumor targeting /
- nanocarriers /
- extracellular activation /
- environmental stimuli

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细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002

Progress on extracellularly activated nanocarriers

计量

细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002

1. 第二军医大学长海医院药学部,上海 200433

2. 第二军医大学药学院药剂学教研室,上海 200433

3. 解放军第522医院,河南洛阳 471003

English Abstract

Progress on extracellularly activated nanocarriers

1. Department of Pharmacy,Changhai Hosptial,Second Military Medical University,Shanghai 200433, China

2. Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

3. The 522th Hospital of PLA,Luoyang,Henan 471003,China

全文HTML

目录

留言板

细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002

Progress on extracellularly activated nanocarriers

计量

出版历程

细胞外激活纳米载药系统研究进展

doi: 10.3969/j.issn.1006-0111.2012.01.002

1. 第二军医大学长海医院药学部,上海 200433 2. 第二军医大学药学院药剂学教研室,上海 200433 3. 解放军第522医院,河南 洛阳 471003

English Abstract

Progress on extracellularly activated nanocarriers

1. Department of Pharmacy,Changhai Hosptial,Second Military Medical University,Shanghai 200433, China 2. Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China 3. The 522th Hospital of PLA,Luoyang,Henan 471003,China

全文HTML

目录

1. 第二军医大学长海医院药学部,上海 200433

2. 第二军医大学药学院药剂学教研室,上海 200433

3. 解放军第522医院,河南洛阳 471003

1. Department of Pharmacy,Changhai Hosptial,Second Military Medical University,Shanghai 200433, China

2. Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China

3. The 522th Hospital of PLA,Luoyang,Henan 471003,China