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多肽类化合物在颅脑创伤中的研究进展

马凯源 章越凡 李铁军

马凯源, 章越凡, 李铁军. 多肽类化合物在颅脑创伤中的研究进展[J]. 药学实践与服务, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
引用本文: 马凯源, 章越凡, 李铁军. 多肽类化合物在颅脑创伤中的研究进展[J]. 药学实践与服务, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
MA Kaiyuan, ZHANG Yuefan, LI Tiejun. Research progress of peptide compounds in traumatic brain injury[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
Citation: MA Kaiyuan, ZHANG Yuefan, LI Tiejun. Research progress of peptide compounds in traumatic brain injury[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004

多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004
基金项目: 上海市卫生和计划生育委员会科研课题(201640404)

Research progress of peptide compounds in traumatic brain injury

  • 摘要: 颅脑创伤每年在全球造成严重的伤亡,至今研究者们依然没有找到有效的临床治疗药物。肽类物质以其安全、易耐受等优势逐渐成为研究开发的热点。对多肽类化合物在颅脑创伤中的神经保护和抗炎作用进行综述。
  • [1] 惠纪元,龚如,梁玉敏,等. 中国颅脑创伤数据库:短期预后因素分析[J]. 中华神经外科杂志,2014,30(1):56-58.
    [2] 江基尧. 中国颅脑创伤研究的现状与未来[J]. 中华医学杂志,2013,93(23):1761-1762.
    [3] Stein DG,Wright DW. Progesterone in the clinical treatment of acute traumatic brain injury[J]. Expert Opin Investig Drugs,2010,19(7):847-857.
    [4] 王克全,徐寒梅. 多肽类药物的研究进展[J]. 药学进展,2015,39(9):642-650.
    [5] Lee EH,Seo SR. Neuroprotective roles of pituitary adenylate cyclase-activating polypeptide in neurodegenerative diseases[J]. BMB Rep,2014,47(7):369-375.
    [6] Katahira M,Yone K,Arishima Y,et al.The neuroprotective effects of PACAP on spinal cord injury (SCI) in rats[J]. Regul Pept,2003,115(1):49.
    [7] Reglodi D,Kiss P,Lubics A,et al. Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo[J]. Curr Pharm Des,2011,17(10):962-972.
    [8] Farkas O,Tamás A,Zsombok A,et al. Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury[J]. Regul Pept,2004,123(1-3):69-75.
    [9] Vukojevic J,Vrdoljak B,Malekinusic D,et al. The effect of BPC 157 on ischemic/reperfusion injuriesin rat brain[J]. FASEB J,2016,30(1Suppl):705-706.
    [10] Tudor M,Jandric I,Marovic A,et al. Traumatic brain injury in mice and pentadecapeptide BPC 157 effect[J]. Regul Pept,2010,160(1-3):26-32.
    [11] Tohyama Y,Sikirié P,Diksic M. Effects of pentadecapeptide BPC157 on regional serotonin synthesis in the rat brain:alpha-methyl-L-tryptophan autoradiographic measurements[J]. Life Sci,2004,76(3):345-357.
    [12] Amiri-Nikpour MR,Nazarbaqhi S,Ahmadi-Salmasi B,et al. Cerebrolysin effects on neurological outcomes and cerebral blood flow in acute ischemic stroke[J]. Neuropsychiatr Dis Treat,2014,10:2299.
    [13] Sharma HS,Zimmermann-Meinzingen S,Johanson CE. Cerebrolysin reduces blood-cerebrospinal fluid barrier permeability change,brain pathology,and functional deficits following traumatic brain injury in the rat[J]. Ann N Y Acad Sci,2010,1199:125-137.
    [14] Chen CC,Wei ST,Tsaia SC,et al. Cerebrolysin enhances cognitive recovery of mild traumatic brain injury patients:double-blind,placebo-controlled,randomized study[J]. Br J Neurosurg,2013,27(6):803-807.
    [15] álvarez XA,Figueroa J,Muresanu D. Peptidergic drugs for the treatment of traumatic brain injury[J]. Futr Neurol,2013,8(2):175-192.
    [16] Faden AI,Fox GB,Fan L,et al. Novel TRH analog improves motor and cognitive recovery after traumatic brain injury in rodents[J]. Am J Physiol,1999,277(4 Pt 2):R1196-R1204.
    [17] Jain KK. Neuroprotection in traumatic brain injury[J]. Drug Discov Today, 2008,13(23-24):1082-1089.
    [18] Faden AI,Knoblach SM,Cernak I,et al. Novel diketopiperazine enhances motor and cognitive recovery after traumatic brain injury in rats and shows neuroprotection in vitro and in vivo[J].J Cerebr Blood Flow Metabol,2003:342-354.
    [19] Faden AI,Movsesyan VA,Knoblach SM,et al. Neuroprotective effects of novel small peptides in vitro and after brain injury[J]. Neuropharmacology,2005,49(3):410-424.
    [20] Faden AI,Knoblach SM,Movsesyan VA,et al. Novel small peptides with neuroprotective and nootropic properties[J]. J Alzheimers Dis,2004,6(6 Suppl):S93-S97.
    [21] 李淑敏. 促红细胞生成素的临床应用进展[J]. 职业与健康,2013,29(21):2862-2864.
    [22] Corwin HL,Gettinger A,Fabian TC,et al. Efficacy and safety of epoetin Alfa in criticallyⅢ patients[J]. New Engl J Med,2007,357(10):965-976.
    [23] Collino M,Thiemermann C,Cerami A,et al. Flipping the molecular switch for innate protection and repair of tissues:Long-lasting effects of a non-erythropoietic small peptide engineered from erythropoietin[J]. Pharmacol Ther,2015,151:32-40.
    [24] Robertson CS,Cherian L,Shah M,et al. Neuroprotection with an erythropoietin mimetic peptide (pHBSP) in a model of mild traumatic brain injury complicated by hemorrhagic shock[J]. J Neurotr,2012,29(6):1156-1166.
    [25] Verghese PB,Castellano JM,Holtzman DM. Apolipoprotein E in Alzheimer's disease and other neurological disorders[J]. Lancet Neurol,2011,10(3):241-252.
    [26] Jiang Y,Brody DL. Administration of COG1410 reduces axonal amyloid precursor protein immunoreactivity and microglial activation after controlled cortical impact in mice[J]. J Neurotr,2012,29(13):2332-2341.
    [27] Laskowitz DT,Mckenna SE,Song P,et al. COG1410,a novel apolipoprotein E-basedpeptide,improves functional recovery in a murine model of traumatic brain injury[J]. J Neurotr,2007,24(7):1093-1107.
    [28] 贺杰,庞金伟,吴越,等. 载脂蛋白E短肽COG1410对蛛网膜下腔出血后早期脑水肿的影响[J]. 第三军医大学学报,2016,38(4):350-355.
    [29] Wu Y,Pang J,Peng J,et al. An apoE-derived mimic peptide,COG1410,alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage[J].Neurosci Lett,2016,627:92-99.
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  • 收稿日期:  2017-07-17
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多肽类化合物在颅脑创伤中的研究进展

doi: 10.3969/j.issn.1006-0111.2017.06.004
    基金项目:  上海市卫生和计划生育委员会科研课题(201640404)

摘要: 颅脑创伤每年在全球造成严重的伤亡,至今研究者们依然没有找到有效的临床治疗药物。肽类物质以其安全、易耐受等优势逐渐成为研究开发的热点。对多肽类化合物在颅脑创伤中的神经保护和抗炎作用进行综述。

English Abstract

马凯源, 章越凡, 李铁军. 多肽类化合物在颅脑创伤中的研究进展[J]. 药学实践与服务, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
引用本文: 马凯源, 章越凡, 李铁军. 多肽类化合物在颅脑创伤中的研究进展[J]. 药学实践与服务, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
MA Kaiyuan, ZHANG Yuefan, LI Tiejun. Research progress of peptide compounds in traumatic brain injury[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
Citation: MA Kaiyuan, ZHANG Yuefan, LI Tiejun. Research progress of peptide compounds in traumatic brain injury[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(6): 495-498,529. doi: 10.3969/j.issn.1006-0111.2017.06.004
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