响应面法优化肉苁蓉松果菊苷肠溶微球的制备

秦翠英; 李荣丽; 李云晶; 陈仁财; 韩静

doi:10.3969/j.issn.1006-0111.2017.05.006

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响应面法优化肉苁蓉松果菊苷肠溶微球的制备

秦翠英, 李荣丽, 李云晶, 陈仁财, 韩静

文章导航 > 药学实践与服务 > 2017 > 35(5): 411-414,432

秦翠英, 李荣丽, 李云晶, 陈仁财, 韩静. 响应面法优化肉苁蓉松果菊苷肠溶微球的制备[J]. 药学实践与服务, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006

引用本文:

QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006

Citation:

QIN Cuiying, LI Rongli, LI Yunjing, CHEN Rencai, HAN Jing. Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology[J]. Journal of Pharmaceutical Practice and Service, 2017, 35(5): 411-414,432. doi: 10.3969/j.issn.1006-0111.2017.05.006

响应面法优化肉苁蓉松果菊苷肠溶微球的制备

doi: 10.3969/j.issn.1006-0111.2017.05.006

沈阳药科大学, 辽宁沈阳 10016

基金项目: 沈阳市科技局专项基金资助项目（F16-205-1-45）

Optimization of the preparation process for echinacoside in Herba Cistanche enteric microspheres by response surface methodology

Shenyang Pharmaceutical University, Shenyang 110016, China

摘要: 目的制备肉苁蓉松果菊苷肠溶微球，筛选最佳制备工艺，并考察其体外释放特性。方法用离子凝胶-干燥法制备肉苁蓉松果菊苷肠溶微球，以包封率为考察指标，用响应面法优化其制备工艺。结果制备肉苁蓉松果菊苷肠溶微球最佳工艺参数：海藻酸钠浓度36.33 mg/ml、氯化钙浓度10.82 mg/ml、壳聚糖浓度10.93 mg/ml。结论优选的工艺稳定、可行，制备的微球包封率高、缓释效果较好。
- 肉苁蓉 /
- 响应面法 /
- 海藻酸钠 /
- 离子凝胶-干燥法 /
- 微球
Abstract: Objective To prepare Herba Cistanche enteric release microspheres, optimize the preparation process and study the releasing characteristics of microspheres in vitro. Methods Ion gelatin-oven drying method was used to prepare Herba Cistanche enteric microspheres. The preparation process was optimized with the aid of a Box-Behnken design. Results The optimal preparation condition was 36.33 mg/ml of sodium alginate, 10.82 mg/ml of calcium chloride and 10.93 mg/ml of chitosan. Conclusion This technology is repeatable and feasible. The microspheres have high entrapment efficiency and good sustained release characteristics.
- Herba Cistanche /
- response surface methodology /
- sodium alginate /
- ion gelatin-oven drying method /
- microspheres

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响应面法优化肉苁蓉松果菊苷肠溶微球的制备

doi: 10.3969/j.issn.1006-0111.2017.05.006

沈阳药科大学, 辽宁沈阳 10016

基金项目: 沈阳市科技局专项基金资助项目（F16-205-1-45）

收稿日期: 2016-11-25
修回日期: 2017-04-25

关键词:

肉苁蓉 /

摘要: 目的制备肉苁蓉松果菊苷肠溶微球，筛选最佳制备工艺，并考察其体外释放特性。方法用离子凝胶-干燥法制备肉苁蓉松果菊苷肠溶微球，以包封率为考察指标，用响应面法优化其制备工艺。结果制备肉苁蓉松果菊苷肠溶微球最佳工艺参数：海藻酸钠浓度36.33 mg/ml、氯化钙浓度10.82 mg/ml、壳聚糖浓度10.93 mg/ml。结论优选的工艺稳定、可行，制备的微球包封率高、缓释效果较好。