Three new triterpene glycosides from Stichopus variegatus
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摘要: 目的 研究花刺参体内的活性皂苷类成分。 方法 运用硅胶、Sephadex LH-20柱色谱等方法进行分离纯化,利用IR,1H、13C NMR,MS等光谱技术鉴定其化学结构。 结果 从花刺参中分离并鉴定出3个化合物,分别为3-O-[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→3)-β-D-吡喃葡萄糖-(1→2)-β-D-吡喃木糖]-海参烷-7,24-二烯-3β,23S-二醇,命名为variegatuside C;3-O-{3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃葡萄糖-(1→2)[β-D-吡喃葡萄糖-(1→4)]-β-D-吡喃木糖}-海参烷-8-烯-3β,23S-二醇,命名为variegatuside D;3-O-{3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃木糖-(1→4)-β-D-吡喃葡萄糖-(1→2)[3-O-甲基-β-D-吡喃葡萄糖-(1→3)-β-D-吡喃葡萄糖-(1→4)]-β-D-吡喃木糖}-海参烷-9-烯-3β,23S-二醇,命名为variegatuside E。 结论 3个化合物均为新化合物。Abstract: Objective To study the chemical constituents from the Stichopus variegatus. Method The compounds were isolated and purified by silica gel column chromatography, Sephadex LH-20 gel filtration and recrystallization. The structures of these compounds were identified through chemical reactions and spectral analyses, such as IR,1H,13C NMR,MS. Results Three compounds were identified as 3-O-[3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyl(1→3)-β-D-glucopyranosyl(1→2)-β-D-xylopyranosyl]-holosta-7,24-diene-3β,23S-diol, named as variegatuside C; 3-O-{3-O-methyl-β-D-glucopy-ranosyl(1→3)-β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl(1→2)[β-D-glucopyranosyl(1→4)]-β-D-xylopyranosyl-holosta-8-ene-3β,23S-diol, named as variegatuside D; 3-O-{3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-xylopyranosyl(1→4)-β-D-glucopyranosyl(1→2)[3-O-methyl-β-D-glucopyranosyl(1→3)-β-D-glucopyranosyl(1→4)]-β-D-xylopyranosyl}-holosta-9-ene-3β,23S-diol, named as variegatuside E. Conclusion All three compounds are new compounds.
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Key words:
- Stichopus variegatus Semper /
- sea cucumber /
- triterpene glycoside
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