Meta-analysis on treatment of lower respiratory tract infection of azatreonam or ceftazidime
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摘要: 目的 评价氨曲南与头孢他啶治疗下呼吸道感染的临床疗效与安全性差异。 方法 通过检索MEDLINE、EMBASE、Pubmed、Cochrane library、CNKI、维普、万方等数据库获得相关检索文献,采用Review Manager 5.2进行系统评价。 结果 荟萃分析(Meta)结果显示,氨曲南治疗下呼吸道感染的总有效率显著高于头孢他啶组(RR=1.15,95%CI为1.09~1.21);细菌清除率、不良反应发生率两组无显著性差异(RR=1.03,95%CI为0.98~1.09;RR=0.66,95%CI为0.39~1.12)。 结论 氨曲南治疗下呼吸道感染的临床疗效优于头孢他啶。Abstract: Objective The aim of the study is to evaluate clinical efficacy and safety of azatreonam or ceftazidime on treatment of lower respiratory tract infection. Methods Four English databases (MEDLINE、EMBASE、Pubmed、Cochrane library) and three Chinese databases (CNKI、VIP、WANFANG) were searched. Meta-analysis was performed using Review Manager 5.2. Results The Meta-analysis revealed azatreonam was superior to ceftazidime in total efficiency (RR=1.15,95% CI is 1.09-1.21). No significant differences are seen between azatreonam and ceftazidime (RR=1.03,95% CI is 0.98-1.09) on the bacterial eradication rates or the incidence of adverse reactions (RR=0.66,95% CI is 0.39-1.12). Conclusion Azatreonam is more effective than ceftazidime on the treatment of lower respiratory tract infection in the clinical practice.
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Key words:
- lower respiratory tract infection /
- azatreonam /
- ceftazidime /
- Mata-analysis
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