Effect of S-adenosylmethionine (SAM) on the treatment of chronic hepatitis B with hyperbilirubinemia
-
摘要: 目的 观察腺苷蛋氨酸治疗慢性乙型肝炎伴胆红素升高的临床疗效及安全性。 方法 符合诊断标准的69例患者随机分为治疗组34例与对照组35例。治疗组采用注射用丁二磺酸腺苷蛋氨酸治疗,对照组采用苦黄注射液治疗,4周为1个疗程,比较两组疗效及安全性。 结果 治疗组总有效率为91.2%,疗效明显优于对照组的68.6% (P<0.05),且治疗后治疗组血清ALT、血清胆红素、TBA等肝功能指标改善程度明显优于对照组 (P<0.01);治疗组未发生药品不良反应,对照组发生3例药品不良反应。 结论 腺苷蛋氨酸治疗慢性乙型肝炎伴胆红素升高临床疗效及安全性优于苦黄。Abstract: Objective To evaluate the clinical efficiencies and safeties of S-adenosylmethionine (SAM) in treatment of 34 patients with chronic hepatitis B complicated hyperbilirubinemia. Methods Patients which meet the diagnostic criteria were randomized into the group with treatment of SAM (the treatment group, 34 cases) and the group with Kuhuang injection (the contrast group, 35 cases), 4 weeks for a course of treatment. The clinical efficacies and safeties were observed in the two groups. Results Compared with the contrast group, the overall efficiency was better in the treatment group (91.2% vs 68.6%, P<0.05), and the curative effects of serum ALT,serum bilirubin,TBA levels were better in the treatment group after treatment (P<0.01). There were no adverse drug reactions in the treatment group and 3 cases with adverse drug reactions in the contrast group. Conclusion The clinical efficiencies and safeties of SAM treatment in patients with chronic hepatitis B complicated hyperbilirubinemia were better than that of Kuhuang injection.
-
Key words:
- chronic hepatitis B /
- hyperbilirubinemia /
- adenosylmethionine /
- Kuhuang injection
-
[1] 郭梦安.不同剂量腺苷蛋氨酸治疗肝内胆汁淤积肝病的疗效观察[J].中国医师杂志,2011,13(12):1702-1703. [2] 陈国友,钱玉凤.腺苷蛋氨酸治疗病毒性肝炎合并高胆红素血症临床肝功能指标观察[J].中国药物经济学,2012,(3):33-34. [3] 郭锦辉, 高卫芳, 贾素洁. 苦黄注射液致不良反应文献分析[J]. 中国医院用药评价与分析,2014,14(1):72-74. [4] 中华医学会肝病学分会,中华医学会感染病学分会.慢性乙型肝炎防治指南(2010年版)[J].肝脏,2011,16(1):2-16. [5] 王秀英,赵 晖.不同剂量腺苷蛋氨酸治疗病毒性肝炎肝内胆汁淤积临床疗效观察[J]. 中国现代医生,2012,50(22):28-29. [6] 汪燕君.腺苷蛋氨酸联合熊去氧胆酸治疗胆汁淤积型药物性肝炎40例[J]. 浙江中西医结合杂志,2012,22(8):615-617. [7] 朱超慧,董迎华,艾正琳,等.药物性胆汁淤积型肝病的治疗研究[J].胃肠病学和肝病学杂志,2014, 23(1):90-93. [8] 谢敬东,赵钢德,谢 青,等.丁二磺酸腺苷蛋氨酸治疗胆汁淤积性肝炎的临床疗效[J].肝脏,2013,18(8):550-552 [9] 盛庆寿,张红星,蒋阳昆,等.腺苷蛋氨酸治疗慢性乙型肝炎高胆红素血症疗效观察[J].胃肠病学和肝病学杂志,2010,19(10):909-910. [10] 陈 威,王晓峰,孙庆丰, 等. 苦黄注射液联合思密达散剂治疗老年戊型肝炎30例临床观察[J].中国中医药科技,2012,19(3):255-256. [11] 毛 果,蔡光先,陈 斌. 1868例慢性乙型肝炎患者中医证候分布特征及与血清病毒学指标的相关性分析[J].湖南中医药大学学报, 2014, 34(4):24-28. [12] 刘娥元.丁二磺酸腺苷蛋氨酸治疗淤胆型病毒性肝炎31例疗效观察[J].吉林医学,2013,34(15):2870-2871. [13] 张永红,肖新强,王文龙,等.不同剂量腺苷蛋氨酸治疗病毒性肝炎临床观察[J].肝脏,2013,18(9):627-628. [14] 赵巍峰,谷高玲,李长安, 等.丁二磺酸腺苷蛋氨酸治疗慢性乙型重症肝炎肝炎临床疗效观察[J].中国实用医药,2013,8(20):161-163. [15] 雷 婷,薛 静,热合曼,等.腺苷蛋氨酸序贯治疗对胆汁淤积性肝病的疗效观察[J].实用临床医药杂志,2012,16(15):130-131. -
点击查看大图
计量
- 文章访问数: 2726
- HTML全文浏览量: 274
- PDF下载量: 424
- 被引次数: 0
下载:
